Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM

Journal of Structural Biology

Volumn 180, Issue 1, 2012, Pages 174-189

  Norlin, Nils ^a   Hellberg, Magnus ^a   Filippov, Andrei ^a,b   Sousa, Alioscka A ^c   Gröbner, Gerhard ^d   Leapman, Richard D ^c   Almqvist, Nils ^a   Antzutkin, Oleg N ^a,e  

^a LULEÅ UNIVERSITY OF TECHNOLOGY   (Sweden)

^b KAZAN STATE UNIVERSITY   (Russian Federation)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^d UMEÅ UNIVERSITY   (Sweden)

^e UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

AFM; Amyloid peptide; Arctic mutation; CD; Mass per length measurements; Polymorphism of amyloid fibrils; Real time growth; Spherical aggregates; STEM; TEM; ThT assay

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; THIOFLAVINE;

ALZHEIMER DISEASE; ARCTIC MUTATION; ARTICLE; ATOMIC FORCE MICROSCOPY; CIRCULAR DICHROISM; CONTROLLED STUDY; FLUORESCENCE; IN VITRO STUDY; MOLECULAR IMAGING; MUTATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; SCANNING TRANSMISSION ELECTRON MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID; AMYLOID BETA-PEPTIDES; BUFFERS; CIRCULAR DICHROISM; HUMANS; KINETICS; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING TRANSMISSION; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; TIME-LAPSE IMAGING;

EID: 84866988080     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2012.06.010     Document Type: Article

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