Stereoselective synthesis and antiviral activity of methyl-substituted cycloSal-pronucleotides

Journal of Medicinal Chemistry

Volumn 55, Issue 16, 2012, Pages 7245-7252

  Rios Morales, Edwuin H ^a   Balzarini, Jan ^b   Meier, Chris ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; METHYL GROUP; PHOSPHATE; PRONUCLEOTIDE; STAVUDINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CHIRALITY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; HYDROLYSIS; ISOMERIZATION; LIPOPHILICITY; NONHUMAN; STEREOCHEMISTRY; SUBSTITUTION REACTION;

ANTI-HIV AGENTS; CELL LINE; DIDEOXYNUCLEOTIDES; DRUG STABILITY; HIV-1; HIV-2; HUMANS; HYDROLYSIS; MUTATION; SOLVENTS; STAVUDINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDINE KINASE; THYMINE NUCLEOTIDES;

EID: 84866914730     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3008085     Document Type: Article

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