WNT/Β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma

British Journal of Cancer

Volumn 107, Issue 7, 2012, Pages 1144-1152

  Rogers, H A ^a   Sousa, S ^b   Salto, C ^b   Arenas, E ^b   Coyle, B ^a   Grundy, R G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

catenin; medulloblastoma; Myc; neuronal differentiation; WNT pathway

Indexed keywords

BETA CATENIN; MYC PROTEIN; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; WNT1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; DOWN REGULATION; HISTOPATHOLOGY; MALE; MEDULLOBLASTOMA; NERVE CELL DIFFERENTIATION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL; WNT SIGNALING PATHWAY;

ANIMALS; BETA CATENIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CEREBELLAR NEOPLASMS; GENES, MYC; MALE; MEDULLOBLASTOMA; MICE; NEURAL STEM CELLS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL; WNT1 PROTEIN;

EID: 84866900033     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2012.377     Document Type: Article

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