Severe alterations of cerebellar cortical development after constitutive activation of Wnt signaling in granule neuron precursors

Molecular and Cellular Biology

Volumn 31, Issue 16, 2011, Pages 3326-3338

  Lorenz, Andreas ^a   Deutschmann, Markus ^a   Ahlfeld, Julia ^a   Prix, Catharina ^a   Koch, Arend ^b   Smits, Ron ^c   Fodde, Riccardo ^d   Kretzschmar, Hans A ^a   Schüller, Ulrich ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d JOSEPHINE NEFKENS INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATAXIA; BRAIN DEVELOPMENT; CARCINOGENESIS; CELL PROLIFERATION; CELL SURVIVAL; CEREBELLUM CORTEX; CEREBELLUM DISEASE; CYTOARCHITECTURE; GRANULE CELL; IN VITRO STUDY; IN VIVO STUDY; MOTOR COORDINATION; MOUSE; MUTANT; NERVE CELL; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; SIGNAL TRANSDUCTION; STEM CELL;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; ATAXIA; CELL DIFFERENTIATION; CELL PROLIFERATION; CEREBRAL CORTEX; MICE; MICE, KNOCKOUT; MOTOR SKILLS DISORDERS; NEURAL STEM CELLS; NEURONS; SIGNAL TRANSDUCTION; WNT PROTEINS;

MUS;

EID: 79961161973     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.05718-11     Document Type: Article

References (36)

1. Adesina, A. M., et al. 2009. Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways. Hum. Pathol. 40:843-853.
2. Altmann, J., and S. A. Bayer. 1997. Development of the cerebellar system in relation to its evolution, structure and functions. CRC Press, New York, NY.
3. Bhat, R. V., J. M. Baraban, R. C. Johnson, B. A. Eipper, and R. E. Mains. 1994. High levels of expression of the tumor-suppressor gene Apc During development of the rat central-nervous-system. J. Neurosci. 14:3059-3071.
4. Chenn, A., and C. A. Walsh. 2002. Regulation of cerebral cortical size by control of cell cycle exit in neural precursors. Science 297:365-369.
5. Eberhart, C. G., T. Tihan, and P. C. Burger. 2000. Nuclear localization and mutation of beta-catenin in medulloblastomas. J. Neuropathol. Exp. Neurol. 59:333-337.
6. Engelkamp, D., P. Rashbass, A. Seawright, and H. V. van. 1999. Role of Pax6 in development of the cerebellar system. Development 126:3585-3596.
7. Fodde, R., et al. 1994. A targeted chain-termination mutation in the mouse apc gene results in multiple intestinal tumors. Proc. Natl. Acad. Sci. U. S. A. 91:8969-8973.
8. Gibson, P., et al. 2010. Subtypes of medulloblastoma have distinct developmental origins. Nature 468:1095-1099.
9. Gilbertson, R. J. 2004. Medulloblastoma: signalling a change in treatment. Lancet Oncol. 5:209-218.
10. Hamilton, S. R., et al. 1995. The molecular basis of Turcot's syndrome. N. Engl. J. Med. 332:839-847.
11. Harada, N., et al. 1999. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 18:5931-5942.
12. Hartmann, W., et al. 2005. Insulin-like growth factor II is involved in the proliferation control of medulloblastoma and its cerebellar precursor cells. Am. J. Pathol. 166:1153-1162.
13. Hirabayashi, Y., et al. 2004. The Wnt/beta-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131:2791-2801.
14. Huang, H. T., et al. 2000. APC mutations in sporadic medulloblastomas. Am. J. Pathol. 156:433-437.
15. Ivaniutsin, U., Y. J. Chen, J. O. Mason, D. J. Price, and T. Pratt. 2009. Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex. Neural Dev. 4:3.
16. Kenney, A. M., and D. H. Rowitch. 2000. Sonic hedgehog promotes G1 cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol. Cell. Biol. 20:9055-9067.
17. Kho, A. T., et al. 2004. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev. 18:629-640.
18. Klein, R. S., et al. 2001. SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development 128:1971-1981.
19. Koch, A., et al. 2001. Somatic mutations of WNT/wingless signaling pathway components in primitive neuroectodermal tumors. Int. J. Cancer 93:445-449.
20. Kool, M., et al. 2008. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One 3:e3088.
21. Kratz, J. E., et al. 2002. Expression of stabilized beta-catenin in differentiated neurons of transgenic mice does not result in tumor formation. BMC Cancer 2:33.
22. Lustig, B., et al. 2002. Negative feedback loop of Wnt signaling through upregulation of conductin/Axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22:1184-1193.
23. Machold, R., and G. Fishell. 2005. Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors. Neuron 48:17-24.
24. Marino, S. 2005. Medulloblastoma: developmental mechanisms out of control. Trends Mol. Med. 11:17-22.
25. McMahon, A. P., and A. Bradley. 1990. The Wnt-1 (Int-1) protooncogene is required for development of a large region of the mouse brain. Cell 62:1073-1085.
26. Miclea, R. L., et al. 2009. Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev. Biol. 9:26.
27. Morin, P. J., et al. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275:1787-1790.
28. Pan, N., I. Jahan, J. E. Lee, and B. Fritzsch. 2009. Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation. Cell Tissue Res. 337:407-428.
29. Powell, S. M., et al. 1992. Apc mutations occur early during colorectal tumorigenesis. Nature 359:235-237.
30. Robanus-Maandag, E. C., et al. 2010. A new conditional Apc-mutant mouse model for colorectal cancer. Carcinogenesis 31:946-952.
31. Schüller, U., and D. H. Rowitch. 2007. Beta-catenin function is required for cerebellar morphogenesis. Brain Res. 1140:161-169.
32. Schüller, U., et al. 2007. Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol. Cell. Biol. 27:8259-8270.
33. ten Donkelaar, H. J., M. Lammens, P. Wesseling, H. O. Thijssen, and W. O. Renier. 2003. Development and developmental disorders of the human cerebellum. J. Neurol. 250:1025-1036.
34. Thompson, M. C., et al. 2006. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J. Clin. Oncol. 24:1924-1931.
35. Wechsler-Reya, R., and M. P. Scott. 2001. The developmental biology of brain tumors. Annu. Rev. Neurosci. 24:385-428.
36. Zurawel, R. H., S. A. Chiappa, C. Allen, and C. Raffel. 1998. Sporadic medulloblastomas contain oncogenic beta-catenin mutations. Cancer Res. 58:896-899.