Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice

Molecular Endocrinology

Volumn 26, Issue 11, 2012, Pages 1883-1895

  Martin, A ^a   David, V ^a   Li, H ^a   Dai, B ^a   Feng, J Q ^b   Quarles, L D ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b BAYLOR COLLEGE OF DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DENTIN MATRIX PROTEIN 1; FIBROBLAST GROWTH FACTOR 23; MESSENGER RNA; PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERALIZATION; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HYPOPHOSPHATEMIC RICKETS; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN INTERACTION; TRANSCRIPTION REGULATION; TRANSGENE; WILD TYPE;

ANIMALS; BODY WEIGHT; CALCIFICATION, PHYSIOLOGIC; EXTRACELLULAR MATRIX PROTEINS; FEMUR; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; PEPTIDE FRAGMENTS; PHENOTYPE; PHEX PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; RNA, MESSENGER; TRANSCRIPTION, GENETIC; X-RAY MICROTOMOGRAPHY;

MUS;

EID: 84866698708     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1062     Document Type: Article

References (38)

1. Lorenz-Depiereux B, Bastepe M, Benet-Pagès A, Amyere M, Wagenstaller J, Müller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH, Olivares JL, Loris C, Ramos FJ, Glorieux F, Vikkula M, Jüppner H, Strom TM 2006 DMP 1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet 38:1248-1250
2. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE 2006 Loss of DMP 1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 38:1310-1315
3. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD 2006 Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab 291:E 38-E 49
4. Liu S, Zhou J, Tang W, Menard R, Feng JQ, Quarles LD 2008 Pathogenic role of Fgf23 in Dmp1-null mice. Am J Physiol Endocrinol Metab 295:E 254-E 261
5. Martin A, Liu S, David V, Li H, Karydis A, Feng JQ, Quarles LD 2011 Bone proteins PHEX and DMP 1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J 25:2551-2562
6. Xiao ZS, Crenshaw M, Guo R, Nesbitt T, Drezner MK, Quarles LD 1998 Intrinsic mineralization defect in Hyp mouse osteoblasts. Am J Physiol 275:E 700-E 708
7. Quarles LD 2008 Endocrine functions of bone in mineral metabolism regulation. J Clin Invest 118:3820-3828
8. Ogbureke KU, Fisher LW 2004 Expression of SIBLINGs and their partner MMPs in salivary glands. J Dent Res 83:664-670
9. Ling Y, Rios HF, Myers ER, Lu Y, Feng JQ, Boskey AL 2005 DMP 1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res 20:2169-2177
10. He G, George A 2004 Dentin matrix protein 1 immobilized on type I collagen fibrils facilitates apatite deposition in vitro. J Biol Chem 279:11649-11656
11. Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ 2011 The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res 26:331-340
12. Addison WN, Masica DL, Gray JJ, McKee MD 2010 Phosphorylation-dependent inhibition of mineralization by osteopontin ASARM peptides is regulated by PHEX cleavage. J Bone Miner Res 25:695-705
13. Addison WN, Nakano Y, Loisel T, Crine P, McKee MD 2008 MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM. J Bone Miner Res 23:1638-1649
14. Yuan B, Takaiwa M, Clemens TL, Feng JQ, Kumar R, Rowe PS, Xie Y, DreznerMK 2008 Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest 118:722-734
15. Erben RG, Mayer D, Weber K, Jonsson K, Jüppner H, Lanske B 2005 Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype. J Bone Miner Res 20:1149-1160
16. Bai X, Miao D, Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC 2002 Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol Endocrinol 16:2913-2925
17. Boskey A, Frank A, Fujimoto Y, Spevak L, Verdelis K, Ellis B, Troiano N, Philbrick W, Carpenter T 2009 The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic mice. Calcif Tissue Int 84:126-137
18. Feng JQ, Huang H, Lu Y, Ye L, Xie Y, Tsutsui TW, Kunieda T, Castranio T, Scott G, Bonewald LB, Mishina Y 2003 The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res 82:776-780
19. Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ 2009 Studies of the DMP 1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs 189:175-185
20. Lu Y, Ye L, Yu S, Zhang S, Xie Y, McKee MD, Li YC, Kong J, Eick JD, Dallas SL, Feng JQ 2007 Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP 1 reveals roles for DMP 1 in early odontogenesis and dentin apposition in vivo. Dev Biol 303:191-201
21. Martin A, David V, Vico L, Thomas T 2008 Impaired energetic metabolism after central leptin signaling leads to massive appendicular bone loss in hindlimb-suspended rats. J Bone Miner Res 23: 2040-2047
22. Lu Y, Liu S, Xie Y, Yu S, Quarles L, Bonewald LF, Feng JQ 2007 Use of the transgenic approach to determine the role of DMP 1 in phosphate regulation. J Musculoskelet Neuronal Interact 7:309
23. Wu H, Teng PN, Jayaraman T, Onishi S, Li J, Bannon L, Huang H, Close J, Sfeir C 2011 Dentin matrix protein 1 (DMP 1) signals via cell surface integrin. J Biol Chem 286:29462-29469
24. Narayanan K, Ramachandran A, Hao J, He G, Park KW, Cho M, George A 2003 Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. J Biol Chem 278:17500-17508
25. Chefetz I, Sprecher E 2009 Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis. Biochim Biophys Acta 1792:847-852
26. Ichikawa S, Austin AM, Gray AK, Econs MJ 2012 A Phex mutation in a murine model of X-linked hypophosphatemia alters phosphate responsiveness of bone cells. J Bone Miner Res 27:453-460
27. Rowe PS, Matsumoto N, Jo OD, Shih RN, Oconnor J, Roudier MP, Bain S, Liu S, Harrison J, Yanagawa N 2006 Correction of the mineralization defect in hyp mice treated with protease inhibitors CA 074 and pepstatin. Bone 39:773-786
28. Liu S, Tang W, Fang J, Ren J, Li H, Xiao Z, Quarles LD 2009 Novel regulators of Fgf23 expression and mineralization in Hyp bone. Mol Endocrinol 23:1505-1518
29. Liu S, Tang W, Zhou J, Vierthaler L, Quarles LD 2007 Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF 23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab 293:E 1636-E 1644
30. Gericke A, Qin C, Sun Y, Redfern R, Redfern D, Fujimoto Y, Taleb H, Butler WT, Boskey AL 2010 Different forms of DMP 1 play distinct roles in mineralization. J Dent Res 89:355-359
31. Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL 2000 MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics 67:54-68
32. Liu S, Rowe PS, Vierthaler L, Zhou J, Quarles LD 2007 Phosphorylated acidic serine-aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity. J Endocrinol 192:261-267
33. Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM, Rowe PS 2008 Degradation of MEPE, DMP 1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology 149:1757-1772
34. David V, Martin A, Hedge AM, Drezner MK, Rowe PS 2011 ASARM peptides: PHEX-dependent and-independent regulation of serum phosphate. Am J Physiol Renal Physiol 300:F 783-F 791
35. David V, Quarles LD 2010 ASARM mineralization hypothesis: a bridge too far? J Bone Miner Res 25:692-694
36. Liu S, Brown TA, Zhou J, Xiao ZS, Awad H, Guilak F, Quarles LD 2005 Role of matrix extracellular phosphoglycoprotein in the pathogenesis of X-linked hypophosphatemia. J Am Soc Nephrol 16:1645-1653
37. David V, Martin A, Hedge AM, Rowe PS 2009 Matrix extracellular phosphoglycoprotein (MEPE) is a new bone renal hormone and vascularization modulator. Endocrinology 150:4012-4023
38. Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, Bonewald LF, Feng JQ 2011 Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res 26:1047-1056