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Volumn 16, Issue 12, 2002, Pages 2913-2925

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATE; PROTEINASE;

EID: 12244263475     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2002-0113     Document Type: Article
Times cited : (94)

References (41)
  • 1
    • 0026680302 scopus 로고
    • X-linked hypophosphataemia: A homologous phenotype in humans and mice with unusual organ-specific gene dosage
    • Scriver CR, Tenenhouse HS 1992 X-linked hypophosphataemia: A homologous phenotype in humans and mice with unusual organ-specific gene dosage. J Inherit Metab Dis 15:610-624
    • (1992) J Inherit Metab Dis , vol.15 , pp. 610-624
    • Scriver, C.R.1    Tenenhouse, H.S.2
  • 2
    • 0020507321 scopus 로고
    • Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets
    • Marie PJ, Glorieux FH 1983 Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets. Calcif Tissue Int 35:443-448
    • (1983) Calcif Tissue Int , vol.35 , pp. 443-448
    • Marie, P.J.1    Glorieux, F.H.2
  • 3
    • 0017032590 scopus 로고
    • Hypophosphatemia: Mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets
    • Eicher EM, Southard JL, Scriver CR, Glorieux FH 1976 Hypophosphatemia: Mouse model for human familial hypophosphatemic (vitamin D-resistant) rickets. Proc Natl Acad Sci USA 73:4667-4671
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 4667-4671
    • Eicher, E.M.1    Southard, J.L.2    Scriver, C.R.3    Glorieux, F.H.4
  • 4
    • 0029114670 scopus 로고
    • Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: Evidence that the HYP gene locus product is an extrarenal factor
    • Nesbitt T, Econs MJ, Byun JK, Martel J, Tenenhouse HS, Drezner MK 1995 Phosphate transport in immortalized cell cultures from the renal proximal tubule of normal and Hyp mice: Evidence that the HYP gene locus product is an extrarenal factor. J Bone Miner Res 10:1327-1333
    • (1995) J Bone Miner Res , vol.10 , pp. 1327-1333
    • Nesbitt, T.1    Econs, M.J.2    Byun, J.K.3    Martel, J.4    Tenenhouse, H.S.5    Drezner, M.K.6
  • 5
    • 0030051013 scopus 로고    scopus 로고
    • Normal phosphate transport in cells from the S2 and S3 segments of Hypmouse proximal renal tubules
    • Nesbitt T, Byun JK, Drezner MK 1996 Normal phosphate transport in cells from the S2 and S3 segments of Hypmouse proximal renal tubules. Endocrinology 137:943-948
    • (1996) Endocrinology , vol.137 , pp. 943-948
    • Nesbitt, T.1    Byun, J.K.2    Drezner, M.K.3
  • 6
    • 0029905668 scopus 로고    scopus 로고
    • Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse
    • Lajeunesse D, Meyer Jr RA, Hamel L 1996 Direct demonstration of a humorally-mediated inhibition of renal phosphate transport in the Hyp mouse. Kidney Int 50:1531-1538
    • (1996) Kidney Int , vol.50 , pp. 1531-1538
    • Lajeunesse, D.1    Meyer R.A., Jr.2    Hamel, L.3
  • 7
    • 0024330123 scopus 로고
    • Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice
    • Meyer Jr RA, Meyer MH, Gray RW 1989 Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice. J Bone Miner Res 4:493-500
    • (1989) J Bone Miner Res , vol.4 , pp. 493-500
    • Meyer R.A., Jr.1    Meyer, M.H.2    Gray, R.W.3
  • 8
    • 0026691973 scopus 로고
    • Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect
    • Nesbitt T, Coffman TM, Griffiths R, Drezner MK 1992 Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect. J Clin Invest 89:1453-1459
    • (1992) J Clin Invest , vol.89 , pp. 1453-1459
    • Nesbitt, T.1    Coffman, T.M.2    Griffiths, R.3    Drezner, M.K.4
  • 9
    • 0026513193 scopus 로고
    • Defective bone formation by Hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect
    • Ecarot B, Glorieux FH, Desbarats M, Travers R, Labelle L 1992 Defective bone formation by Hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect. J Bone Miner Res 7:215-220
    • (1992) J Bone Miner Res , vol.7 , pp. 215-220
    • Ecarot, B.1    Glorieux, F.H.2    Desbarats, M.3    Travers, R.4    Labelle, L.5
  • 11
    • 0028912606 scopus 로고
    • Effect of 1,25-dihydroxyvitamin D3 treatment on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice
    • Ecarot B, Glorieux FH, Desbarats M, Travers R, Labelle L 1995 Effect of 1,25-dihydroxyvitamin D3 treatment on bone formation by transplanted cells from normal and X-linked hypophosphatemic mice. J Bone Miner Res 10:424-431
    • (1995) J Bone Miner Res , vol.10 , pp. 424-431
    • Ecarot, B.1    Glorieux, F.H.2    Desbarats, M.3    Travers, R.4    Labelle, L.5
  • 13
    • 0029160578 scopus 로고
    • A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets
    • The HYP Consortium 1995 A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. Nat Genet 11:130-136
    • (1995) Nat Genet , vol.11 , pp. 130-136
  • 14
    • 0030586965 scopus 로고    scopus 로고
    • cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone
    • Du L, Desbarats M, Viel J, Glorieux FH., Cawthorn C, Ecarot B 1996 cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone. Genomics 36:22-28
    • (1996) Genomics , vol.36 , pp. 22-28
    • Du, L.1    Desbarats, M.2    Viel, J.3    Glorieux, F.H.4    Cawthorn, C.5    Ecarot, B.6
  • 16
    • 0035340784 scopus 로고    scopus 로고
    • Characterization of PHEX endopeptidase catalytic activity: Identification of parathyroid-hormone-related peptide 107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors
    • Boileau G, Tenenhouse HS, Desgroseillers L, Crine P 2001 Characterization of PHEX endopeptidase catalytic activity: Identification of parathyroid-hormone-related peptide 107-139 as a substrate and osteocalcin, PPi and phosphate as inhibitors. Biochem J 355:707-713
    • (2001) Biochem J , vol.355 , pp. 707-713
    • Boileau, G.1    Tenenhouse, H.S.2    Desgroseillers, L.3    Crine, P.4
  • 19
    • 0030938927 scopus 로고    scopus 로고
    • Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice
    • Beck L, Soumounou Y, Martel J, Krishnamurthy G, Gauthier C, Goodyer CG, Tenenhouse HS 1997 Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice. J Clin Invest 99:1200-1209
    • (1997) J Clin Invest , vol.99 , pp. 1200-1209
    • Beck, L.1    Soumounou, Y.2    Martel, J.3    Krishnamurthy, G.4    Gauthier, C.5    Goodyer, C.G.6    Tenenhouse, H.S.7
  • 21
    • 0030954146 scopus 로고    scopus 로고
    • Cloning and sequencing of human PEX from a bone cDNA library: Evidence for its developmental stage-specific regulation in osteoblasts
    • Guo R, Quarles LD 1997 Cloning and sequencing of human PEX from a bone cDNA library: Evidence for its developmental stage-specific regulation in osteoblasts. J Bone Miner Res 12:1009-1017
    • (1997) J Bone Miner Res , vol.12 , pp. 1009-1017
    • Guo, R.1    Quarles, L.D.2
  • 23
    • 0035107364 scopus 로고    scopus 로고
    • Osteomalacia in Hyp mice is associated with abnormal Phex expression and with altered bone matrix protein expression and deposition
    • Miao D, Bai X, Panda D, McKee MD, Karaplis AC, Goltzman D 2001 Osteomalacia in Hyp mice is associated with abnormal Phex expression and with altered bone matrix protein expression and deposition. Endocrinology 142:926-939
    • (2001) Endocrinology , vol.142 , pp. 926-939
    • Miao, D.1    Bai, X.2    Panda, D.3    McKee, M.D.4    Karaplis, A.C.5    Goltzman, D.6
  • 24
    • 0028999875 scopus 로고
    • Separate cis-acting DNA elements of the mouse pro-α1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice
    • Rossert J, Eberspaecher H, de Crombrugghe B 1995 Separate cis-acting DNA elements of the mouse pro-α1(I) collagen promoter direct expression of reporter genes to different type I collagen-producing cells in transgenic mice. J Cell Biol 129:1421-1432
    • (1995) J Cell Biol , vol.129 , pp. 1421-1432
    • Rossert, J.1    Eberspaecher, H.2    De Crombrugghe, B.3
  • 25
    • 0018961064 scopus 로고
    • Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse
    • Meyer Jr RA, Gray RW, Meyer M 1980 Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse. Endocrinology 107:1577-1581
    • (1980) Endocrinology , vol.107 , pp. 1577-1581
    • Meyer R.A., Jr.1    Gray, R.W.2    Meyer, M.3
  • 29
    • 0033930433 scopus 로고    scopus 로고
    • The effects of bone marrow transplantation on X-linked hypophosphatemic mice
    • Miyamura T, Tanaka H, Inoue M, Ichinose Y, Seino Y 2000 The effects of bone marrow transplantation on X-linked hypophosphatemic mice. J Bone Miner Res 15:1451-1458
    • (2000) J Bone Miner Res , vol.15 , pp. 1451-1458
    • Miyamura, T.1    Tanaka, H.2    Inoue, M.3    Ichinose, Y.4    Seino, Y.5
  • 30
    • 0034715532 scopus 로고    scopus 로고
    • Phex cDNA cloning from rat bone and studies on phex mRNA expression: Tissue-specificity, age-dependency, and regulation by insulin-like growth factor (IGF) I in vivo
    • Zoidis E, Zapf J, Schmid C 2000 Phex cDNA cloning from rat bone and studies on phex mRNA expression: Tissue-specificity, age-dependency, and regulation by insulin-like growth factor (IGF) I in vivo. Mol Cell Endocrinol 168:41-51
    • (2000) Mol Cell Endocrinol , vol.168 , pp. 41-51
    • Zoidis, E.1    Zapf, J.2    Schmid, C.3
  • 32
    • 0033831555 scopus 로고    scopus 로고
    • mRNA expression of Phex in mice and rats: The effect of low phosphate diet
    • Meyer MH, Meyer Jr RA 2000 mRNA expression of Phex in mice and rats: The effect of low phosphate diet. Endocrine 13:81-87
    • (2000) Endocrine , vol.13 , pp. 81-87
    • Meyer, M.H.1    Meyer R.A., Jr.2
  • 33
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • The ADHR Consortium 2000 Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26:345-348
    • (2000) Nat Genet , vol.26 , pp. 345-348
  • 35
    • 0035932945 scopus 로고    scopus 로고
    • FGF23, hypophosphatemia, and rickets: Has phosphatonin been found?
    • Strewler GJ 2001 FGF23, hypophosphatemia, and rickets: Has phosphatonin been found? Proc Natl Acad Sci USA 98:5945-5946
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5945-5946
    • Strewler, G.J.1
  • 36
    • 0036479315 scopus 로고    scopus 로고
    • Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype
    • Liu S, Guo R, Tu Q, Quarles LD 2002 Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype. J Biol Chem 277:3686-3697
    • (2002) J Biol Chem , vol.277 , pp. 3686-3697
    • Liu, S.1    Guo, R.2    Tu, Q.3    Quarles, L.D.4
  • 37
    • 0035874943 scopus 로고    scopus 로고
    • Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone
    • Argiro L, Desbarats M, Glorieux FH, Ecarot B 2001 Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone. Genomics 74:342-351
    • (2001) Genomics , vol.74 , pp. 342-351
    • Argiro, L.1    Desbarats, M.2    Glorieux, F.H.3    Ecarot, B.4
  • 38
    • 0031773338 scopus 로고    scopus 로고
    • Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter
    • Muller YL, Collins JF, Ghishan FK 1998 Genetic screening for X-linked hypophosphatemic mice and ontogenic characterization of the defect in the renal sodium-phosphate transporter. Pediatr Res 44:633-638
    • (1998) Pediatr Res , vol.44 , pp. 633-638
    • Muller, Y.L.1    Collins, J.F.2    Ghishan, F.K.3
  • 40
    • 0026656651 scopus 로고
    • Ultrastructure of human osteoblasts and associated matrix in culture
    • Kassem M, Rungby J, Mosekilde L, Eriksen EF 1992 Ultrastructure of human osteoblasts and associated matrix in culture. APMIS 100:490-497
    • (1992) APMIS , vol.100 , pp. 490-497
    • Kassem, M.1    Rungby, J.2    Mosekilde, L.3    Eriksen, E.F.4
  • 41
    • 0022362862 scopus 로고
    • A simple micro-method for collagen and total protein determination in formalin-fixed paraffin-embedded sections
    • Lopez-De Leon A, Rojkind M 1985 A simple micro-method for collagen and total protein determination in formalin-fixed paraffin-embedded sections. J Histochem Cytochem 33:737-743
    • (1985) J Histochem Cytochem , vol.33 , pp. 737-743
    • Lopez-De Leon, A.1    Rojkind, M.2


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