Novel regulators of Fgf23 expression and mineralization in Hyp bone

Molecular Endocrinology

Volumn 23, Issue 9, 2009, Pages 1505-1518

  Liu, Shiguang ^a   Tang, Wen ^a   Fang, Jianwen ^b   Ren, Jinyu ^a   Li, Hua ^a   Xiao, Zhousheng ^a   Quarles, L D ^a,c  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c MS 3018 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CARBONATE DEHYDRATASE III; CARBONATE DEHYDRATASE XII; EARLY GROWTH RESPONSE FACTOR 2; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 23; GLYCOSYLTRANSFERASE; KERATINOCYTE GROWTH FACTOR; OSTEOCALCIN; PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; PROCOLLAGEN C PROTEINASE; PROPROTEIN CONVERTASE 5; SCLEROSTIN; SODIUM CHLORIDE COTRANSPORTER; THROMBOSPONDIN; WNT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOASSAY; BONE MINERALIZATION; CONTROLLED STUDY; CORTICAL BONE; DOWN REGULATION; ENZYME REGULATION; EXTRACELLULAR MATRIX; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; BETA CATENIN; DISEASE MODELS, ANIMAL; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; MALE; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; OSTEOCYTES; PHEX PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; SIGNAL TRANSDUCTION;

MUS;

EID: 69449107033     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0085     Document Type: Article

References (74)

1. Ruchon AF, Tenenhouse HS, Marcinkiewicz M, Siegfried G, Aubin JE, DesGroseillers L, Crine P, Boileau G 2000 Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers. J Bone Miner Res 15:1440-1450 (Pubitemid 30484513)
2. Miao D, Bai X, Panda D, McKee M, Karaplis A, Goltzman D 2001 Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology 142:926-939 (Pubitemid 32222443)
3. Liu S, Tang W, Zhou J, Stubbs JR, Luo Q, Pi M, Quarles LD 2006 Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D. J Am Soc Nephrol 17:1305-1315 (Pubitemid 43673410)
4. Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, Takeuchi Y, Fujita T, Fukumoto S, Yamashita T 2001 Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci USA 98:6500-6505 (Pubitemid 32488266)
5. Larsson T, Marsell R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Jüppner H, Jonsson KB 2004 Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology 145:3087-3094 (Pubitemid 38829975)
6. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD 2006 Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab 291:E38-E49 (Pubitemid 44035308)
7. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M 2006 Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281:6120-6123 (Pubitemid 43847540)
8. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T 2006 Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444:770-774 (Pubitemid 44949607)
9. Yuan B, Takaiwa M, Clemens TL, Feng JQ, Kumar R, Rowe PS, Xie Y, Drezner MK 2008 Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest 118:722-734 (Pubitemid 351206560)
10. Liu S, Tang W, Zhou J, Vierthaler L, Quarles LD 2007 Distinct roles for intrinsic osteocyte abnormalities and systemic factors in regulation of FGF23 and bone mineralization in Hyp mice. Am J Physiol Endocrinol Metab 293:E1636-E644 (Pubitemid 350255114)
11. Xiao ZS, Crenshaw M, Guo R, Nesbitt T, Drezner MK, Quarles LD 1998 Intrinsic mineralization defect in Hyp mouse osteoblasts. Am J Physiol 275:E700-E708 (Pubitemid 128732059)
12. Campos M, Couture C, Hirata IY, Juliano MA, Loisel TP, Crine P, Juliano L, Boileau G, Carmona AK 2003 Human recombinant endopeptidase PHEX has a strict S1′ specificity for acidic residues and cleaves peptides derived from fibroblast growth factor-23 and matrix extracellular phosphoglycoprotein. Biochem J 373:271-279 (Pubitemid 36819521)
13. Guo R, Liu S, Spurney RF, Quarles LD 2001 Analysis of recombinant Phex: an endopeptidase in search of a substrate. Am J Physiol Endocrinol Metab 281:E837-E847 (Pubitemid 33781026)
14. Lorenz-Depiereux B, Bastepe M, Benet-Pagès A, Amyere M, Wagenstaller J, Müller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH, Olivares JL, Loris C, Ramos FJ, Glorieux F, Vikkula M, Jüppner H, Strom TM 2006 DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet 38:1248-1250 (Pubitemid 44646286)
15. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE 2006 Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet 38:1310-1315 (Pubitemid 44646294)
16. Martin A, David V, Laurence JS, Schwarz PM, Lafer EM, Hedge AM, Rowe PS 2008 Degradation of MEPE, DMP1, and release of SIBLING ASARM-peptides (minhibins): ASARM-peptide(s) are directly responsible for defective mineralization in HYP. Endocrinology 149:1757-1772
17. Rowe PS, Matsumoto N, Jo OD, Shih RN, Oconnor J, Roudier MP, Bain S, Liu S, Harrison J, Yanagawa N 2006 Correction of the mineralization defect in hyp mice treated with protease inhibitors CA074 and pepstatin. Bone 39:773-786 (Pubitemid 44335882)
18. Raouf A, Seth A 2002 Discovery of osteoblast-associated genes using cDNA microarrays. Bone 30:463-471 (Pubitemid 34204120)
19. Roman-Roman S, Garcia T, Jackson A, Theilhaber J, Rawadi G, Connolly T, Spinella-Jaegle S, Kawai S, Courtois B, Bushnell S, Auberval M, Call K, Baron R 2003 Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro. Bone 32:474-482 (Pubitemid 39665706)
20. Stains JP, Civitelli R 2003 Genomic approaches to identifying transcriptional regulators of osteoblast differentiation. Genome Biol 4:222 (Pubitemid 36896676)
21. Vaes BL, Dechering KJ, Feijen A, Hendriks JM, Lefèvre C, Mummery CL, Olijve W, van Zoelen EJ, Steegenga WT 2002 Comprehensive microarray analysis of bone morphogenetic protein 2-induced osteoblast differentiation resulting in the identification of novel markers for bone development. J Bone Miner Res 17:2106-2118 (Pubitemid 35416746)
22. Vaes BL, Ducy P, Sijbers AM, Hendriks JM, van Someren EP, de Jong NG, van den Heuvel ER, Olijve W, van Zoelen EJ, Dechering KJ 2006 Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation. Bone 39:724-738 (Pubitemid 44311726)
23. Skaper SD, Kee WJ, Facci L, Macdonald G, Doherty P, Walsh FS 2000 The FGFR1 inhibitor PD 173074 selectively and potently antagonizes FGF-2 neurotrophic and neurotropic effects. J Neurochem 75:1520-1527 (Pubitemid 30694668)
24. Mori S, Wu CY, Yamaji S, Saegusa J, Shi B, Ma Z, Kuwabara Y, Lam KS, Isseroff RR, Takada YK, Takada Y2008 Direct binding of integrin αvβ3 to FGF1 plays a role in FGF1 signaling. J Biol Chem 283:18066-18075
25. Brigstock DR 2003 The CCN family: a new stimulus package. J Endocrinol 178:169-175
26. Berndt T, Craig TA, Bowe AE, Vassiliadis J, Reczek D, Finnegan R, Jan De Beur SM, Schiavi SC, Kumar R 2003 Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 112:785-794 (Pubitemid 38057719)
27. Carpenter TO, Ellis BK, Insogna KL, Philbrick WM, Sterpka J, Shimkets R 2005 FGF7 - an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J Clin Endocrinol Metab 90:1012-1020 (Pubitemid 40279227)
28. Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T 2003 Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498-2504 (Pubitemid 37428274)
29. White KE, Cabral JM, Davis SI, Fishburn T, Evans WE, Ichikawa S, Fields J, Yu X, Shaw NJ, McLellan NJ, McKeown C, Fitzpatrick D, Yu K, Ornitz DM, Econs MJ 2005 Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation. Am J Hum Genet 76:361-367 (Pubitemid 40129563)
30. Nauman EA, Sakata T, Keaveny TM, Halloran BP, Bikle DD 2003 bFGF administration lowers the phosphate threshold for mineralization in bone marrow stromal cells. Calcif Tissue Int 73:147-152 (Pubitemid 37082361)
31. Sobue T, Naganawa T, Xiao L, Okada Y, Tanaka Y, Ito M, Okimoto N, Nakamura T, Coffin JD, Hurley MM 2005 Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice. J Cell Biochem 95:83-94 (Pubitemid 41420218)
32. Quarles LD 2008 Endocrine functions of bone in mineral metabolism regulation. J Clin Invest 118:3820-3828
33. Kettunen P, Laurikkala J, Itäranta P, Vainio S, Itoh N, Thesleff I 2000 Associations of FGF-3 and FGF-10 with signaling networks regulating tooth morphogenesis. Dev Dyn 219:322-332 (Pubitemid 30822543)
34. Liu P, Lu J, Cardoso WV, Vaziri C 2008 The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase. Mol Biol Cell 19:248-261 (Pubitemid 351186150)
35. Trevant B, Gaur T, Hussain S, Symons J, Komm BS, Bodine PV, Stein GS, Lian JB 2008 Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development. J Cell Physiol 217:113-126
36. Moeller C, Swindell EC, Kispert A, Eichele G 2003 Carboxypeptidase Z (CPZ) modulates Wnt signaling and regulates the development of skeletal elements in the chicken. Development 130:5103-5111 (Pubitemid 37369670)
37. Wang L, Shao YY, Ballock RT 2009 Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling pathways in growth plate chondrocytes. J Bone Miner Res 24:265-273
38. van Bezooijen RL, Roelen BA, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P, Löwik CW 2004 Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med 199:805-814
39. Szumska D, Pieles G, Essalmani R, Bilski M, Mesnard D, Kaur K, Franklyn A, El Omari K, Jefferis J, Bentham J, Taylor JM, Schneider JE, Arnold SJ, Johnson P, Tymowska-Lalanne Z, Stammers D, Clarke K, Neubauer S, Morris A, Brown SD, Shaw-Smith C, Cama A, Capra V, Ragoussis J, Constam D, Seidah NG, Prat A, Bhattacharya S 2008 VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev 22:1465-1477 (Pubitemid 351793081)
40. Essalmani R, Zaid A, Marcinkiewicz J, Chamberland A, Pasquato A, Seidah NG, Prat A 2008 In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate. Proc Natl Acad Sci USA 105:5750-5755
41. Ichikawa S, Imel EA, Sorenson AH, Severe R, Knudson P, Harris GJ, Shaker JL, Econs MJ 2006 Tumoral calcinosis presenting with eyelid calcifications due to novel missense mutations in the glycosyl transferase domain of the GALNT3 gene. J Clin Endocrinol Metab 91:4472-4475 (Pubitemid 44833425)
42. Chefetz I, Heller R, Galli-Tsinopoulou A, Richard G, Wollnik B, Indelman M, Koerber F, Topaz O, Bergman R, Sprecher E, Schoenau E 2005 A novel homozygous missense mutation in FGF23 causes familial tumoral calcinosis associated with disseminated visceral calcification. Hum Genet 118:261-266 (Pubitemid 41672088)
43. Barbieri AM, Filopanti M, Bua G, Beck-Peccoz P 2007 Two novel nonsense mutations in GALNT3 gene are responsible for familial tumoral calcinosis. J Hum Genet 52:464-468 (Pubitemid 46669301)
44. Lee HX, Ambrosio AL, Reversade B, De Robertis EM 2006 Embryonic dorsal-ventral signaling: secreted frizzled-related proteins as inhibitors of tolloid proteinases. Cell 124:147-159 (Pubitemid 43069316)
45. Steiglitz BM, Ayala M, Narayanan K, George A, Greenspan DS 2004 Bone morphogenetic protein-1/Tolloid-like proteinases process dentin matrix protein-1. J Biol Chem 279:980-986 (Pubitemid 38082619)
46. Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S 1998 Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19:271-273 (Pubitemid 28309341)
47. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, Goding JW, Terkeltaub R, Millan JL 2002 Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 99:9445-9449 (Pubitemid 34764633)
48. Laizé V, Martel P, Viegas CS, Price PA, Cancela ML 2005 Evolution of matrix and bone γ-carboxyglutamic acid proteins in vertebrates. J Biol Chem 280:26659-26668 (Pubitemid 41040698)
49. Luo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G 1997 Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein. Nature 386:78-81 (Pubitemid 27130923)
50. Gopalakrishnan R, Suttamanatwong S, Carlson AE, Franceschi RT 2005 Role of matrix Gla protein in parathyroid hormone inhibition of osteoblast mineralization. Cells Tissues Organs 181:166-175
51. Narouz-Ott L, Maurer P, Nitsche DP, Smyth N, Paulsson M 2000 Thrombospondin-4 binds specifically to both collagenous and noncollagenous extracellular matrix proteins via its C-terminal domains. J Biol Chem 275:37110-37117 (Pubitemid 32002129)
52. Posey KL, Hankenson K, Veerisetty AC, Bornstein P, Lawler J, Hecht JT 2008 Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin- 5, and type IX collagen. Am J Pathol 172:1664-1674 (Pubitemid 351793357)
53. Hankenson KD, Hormuzdi SG, Meganck JA, Bornstein P 2005 Mice with a disruption of the thrombospondin 3 gene differ in geometric and biomechanical properties of bone and have accelerated development of the femoral head. Mol Cell Biol 25:5599-5606 (Pubitemid 40853594)
54. Ueno A, Miwa Y, Miyoshi K, Horiguchi T, Inoue H, Ruspita I, Abe K, Yamashita K, Hayashi E, Noma T 2006 Constitutive expression of thrombospondin 1 in MC3T3-E1 osteoblastic cells inhibits mineralization. J Cell Physiol 209:322-332 (Pubitemid 44484622)
55. Venta PJ, Welty RJ, Johnson TM, Sly WS, Tashian RE 1991 Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His- Tyr): complete structure of the normal human CA II gene. Am J Hum Genet 49:1082-1090
56. Sitara D, Kim S, Razzaque MS, Bergwitz C, Taguchi T, Schüler C, Erben RG, Lanske B 2008 Genetic evidence of serum phosphatein-dependent functions of FGF-23 on bone. PLoS Genet 4:e1000154
57. Liu S, Vierthaler L, Tang W, Zhou J, Quarles LD 2008 FGFR3 and 4 do not mediate renal effectso of FGF23 in vivo. J Am Soc Nephrol 19:2342-2350
58. Wu M, Li J, Engleka KA, Zhou B, Lu MM, Plotkin JB, Epstein JA 2008 Persistent expression of Pax3 in the neural crest causes cleft palate and defective osteogenesis in mice. J Clin Invest 118:2076-2087 (Pubitemid 351872327)
59. Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G 1995 BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9:2808-2820
60. Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR 2008 New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454:1000-1004
61. Reddy MA, Li SL, Sahar S, Kim YS, Xu ZG, Lanting L, Natarajan R 2006 Key role of Src kinase in S100B-induced activation of the receptor for advanced glycation end products in vascular smooth muscle cells. J Biol Chem 281:13685-13693 (Pubitemid 43855284)
62. Shanmugam N, Reddy MA, Natarajan R 2008 Distinct roles of heterogeneous nuclear ribonuclear protein K and microRNA-16 in cyclooxygenase-2 RNA stability induced by S100b, a ligand of the receptor for advanced glycation end products. J Biol Chem 283:36221-36233
63. Maier R, Glatz A, Mosbacher J, Bilbe G 1997 Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. Biochem Biophys Res Commun 237:297-302 (Pubitemid 27406023)
64. Nakano Y, Addison WN, Kaartinen MT 2007 ATP-mediated mineralization of MC3T3 E1 osteoblast cultures. Bone 41:549-561 (Pubitemid 47385436)
65. Orriss IR, Utting JC, Brandao-Burch A, Colston K, Grubb BR, Burnstock G, Arnett TR 2007 Extracellular nucleotides block bone mineralization in vitro: evidence for dual inhibitory mechanisms involving both P2Y2 receptors and pyrophosphate. Endocrinology 148:4208-4216
66. Tuckey RC, Li W, Zjawiony JK, Zmijewski MA, Nguyen MN, Sweatman T, Miller D, Slominski A 2008 Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J 275:2585-2596 (Pubitemid 351600097)
67. Meyer MH, Dulde E, Meyer Jr RA 2004 The genomic response of the mouse kidney to low-phosphate diet is altered in X-linked hypophosphatemia. Physiol Genomics 18:4-11 (Pubitemid 39319481)
68. Liu S, Zhou J, Tang W, Menard R, Feng JQ, Quarles LD 2008 Pathogenic role of Fgf23 in Dmp1-null mice. Am J Physiol Endocrinol Metab 295:E254-E261
69. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, Vingron M 2001 Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29:365-371 (Pubitemid 34326681)
70. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408 (Pubitemid 34164012)
71. Liu S, Guo R, Simpson LG, Xiao ZS, Burnham CE, Quarles LD 2003 Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem 278:37419-37426 (Pubitemid 37175262)
72. Zou L, Cortez D, Elledge SJ 2002 Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev 16:198-208 (Pubitemid 34075812)
73. Irizarry RA, Bolstad BM, Collin F, Cope LM, Hobbs B, Speed TP 2003 Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res 31:e15
74. Maere S, Heymans K, Kuiper M 2005 BiNGO: a Cytoscape plugin to assess overrepresentation of gene ontology categories in biological networks. Bioinformatics 21:3448-3449 (Pubitemid 41222459)