Unique roles of phosphorus in endochondral bone formation and osteocyte maturation

Journal of Bone and Mineral Research

Volumn 26, Issue 5, 2011, Pages 1047-1056

  Zhang, Rong ^a,b   Lu, Yongbo ^b   Ye, Ling ^c   Yuan, Baozhi ^d   Yu, Shibin ^b   Qin, Chunlin ^b   Xie, Yixia ^b   Gao, Tian ^b   Drezner, Marc K ^d   Bonewald, Lynda F ^c   Feng, Jian Q ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b BAYLOR COLLEGE OF DENTISTRY   (United States)

^c UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

DMP 1; FGF 23; HYPOPHOSPHATEMIC RICKETS; OSTEOCYTE; PHOSPHATE HOMEOSTASIS

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCIUM; CYTOKINE ANTIBODY; DENTIN MATRIX PROTEIN 1; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR 23 ANTIBODY; FLUOROCHROME; MESSENGER RNA; MOLECULAR MARKER; NEUTRALIZING ANTIBODY; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PHOSPHATE; SCLEROSTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; BONE RADIOGRAPHY; BONE REMODELING; CALCIUM BLOOD LEVEL; CALVARIA; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; ENCHONDRAL OSSIFICATION; EXTRACELLULAR MATRIX; FIELD EMISSION SCANNING ELECTRON MICROSCOPY; GROWTH PLATE; HISTOPATHOLOGY; HYPOPHOSPHATEMIC RICKETS; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METATARSAL BONE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; ORGAN CULTURE; OSTEOBLAST; OSTEOCLAST; OSTEOCYTE; OSTEOLYSIS; PHOSPHATE BLOOD LEVEL; PHOSPHATE METABOLISM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTIBODIES; BIOLOGICAL MARKERS; BONE REMODELING; CELL DIFFERENTIATION; EXTRACELLULAR MATRIX PROTEINS; FIBROBLAST GROWTH FACTORS; HOMEOSTASIS; MICE; MICE, KNOCKOUT; OSTEOBLASTS; OSTEOCLASTS; OSTEOCYTES; OSTEOGENESIS; PHOSPHATES; PHOSPHORUS;

EID: 79955640759     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.294     Document Type: Article

References (37)

1. Feng JQ, Ward LM, Liu S, et al. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006; 38: 1310-1315. (Pubitemid 44646294)
2. Lorenz-Depiereux B, Bastepe M, Benet-Pages A, et al. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet. 2006; 38: 1248-1250. (Pubitemid 44646286)
3. Ling Y, Rios HF, Myers ER, Lu Y, Feng JQ, Boskey AL., DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. J Bone Miner Res. 2005; 20: 2169-2177. (Pubitemid 41698780)
4. Farrow EG, Davis SI, Ward LM, et al. Molecular analysis of DMP1 mutants causing autosomal recessive hypophosphatemic rickets. Bone. 2009; 44: 287-294.
5. Lu Y, Yuan B, Qin C, et al. The biological function of DMP1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res. 2011; 26: 331-340.
6. Franz-Odendaal TA, Hall BK, Witten PE., Buried alive: how osteoblasts become osteocytes. Dev Dyn. 2006; 235: 176-190. (Pubitemid 46939715)
7. Noble BS., The osteocyte lineage. Arch Biochem Biophys. 2008; 473: 106-111.
8. Schiavi SC, Kumar R., The phosphatonin pathway: new insights in phosphate homeostasis. Kidney international. 2004; 65: 1-14. (Pubitemid 38037486)
9. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD., Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab. 2006; 291: E38-49. (Pubitemid 44035308)
10. Sitara D, Razzaque MS, Hesse M, et al. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004; 23: 421-432. (Pubitemid 39576657)
11. Shimada T, Mizutani S, Muto T, et al. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A. 2001; 98: 6500-6505. (Pubitemid 32488266)
12. Shimada T, Kakitani M, Yamazaki Y, et al. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest. 2004; 113: 561-568. (Pubitemid 38542505)
13. Qin C, D'Souza R, Feng JQ., Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. J Dent Res. 2007; 86: 1134-1141.
14. Liu S, Guo R, Simpson LG, Xiao ZS, Burnham CE, Quarles LD., Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem. 2003; 278: 37419-37426. (Pubitemid 37175262)
15. Ruchon AF, Tenenhouse HS, Marcinkiewicz M, et al. Developmental expression and tissue distribution of Phex protein: effect of the Hyp mutation and relationship to bone markers. J Bone Miner Res. 2000; 15: 1440-1450. (Pubitemid 30484513)
16. Sitara D, Kim S, Razzaque MS, et al. Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. PLoS Genet. 2008; 4: e1000154.
17. Feng JQ, Huang H, Lu Y, et al. The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. J Dent Res. 2003; 82: 776-780. (Pubitemid 41766106)
18. Ye L, Mishina Y, Chen D, et al. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. J Biol Chem. 2005; 280: 6197-6203. (Pubitemid 40280104)
19. Yamazaki Y, Okazaki R, Shibata M, et al. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J Clin Endocrinol Metab. 2002; 87: 4957-4960. (Pubitemid 35316332)
20. Yamazaki Y, Tamada T, Kasai N, et al. Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23. J Bone Miner Res. 2008; 23: 1509-1518.
21. Feng JQ, Zhang J, Dallas SL, et al. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002; 17: 1822-1831.
22. Zhao S, Zhang YK, Harris S, Ahuja SS, Bonewald LF., MLO-Y4 osteocyte-like cells support osteoclast formation and activation. J Bone Miner Res. 2002; 17: 2068-2079. (Pubitemid 35239208)
23. Ragab AA, Lavish SA, Banks MA, Goldberg VM, Greenfield EM., Osteoclast differentiation requires ascorbic acid. J Bone Miner Res. 1998; 13: 970-977. (Pubitemid 28265275)
24. Lu Y, Ye L, Yu S, et al. Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Developmental biology. 2007; 303: 191-201. (Pubitemid 46241097)
25. Fen JQ, Zhang J, Dallas SL, et al. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. J Bone Miner Res. 2002; 17: 1822-1831.
26. Qin C, Brunn JC, Cook RG, et al. Evidence for the proteolytic processing of dentin matrix protein 1. Identification and characterization of processed fragments and cleavage sites. J Biol Chem. 2003; 278: 34700-34708. (Pubitemid 37553320)
27. Zhang K, Barragan-Adjemian C, Ye L, et al. E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation. Mol Cell Biol. 2006; 26: 4539-4552. (Pubitemid 43877574)
28. Miao D, Bai X, Panda D, McKee M, Karaplis A, Goltzman D., Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology. 2001; 142: 926-939. (Pubitemid 32222443)
29. Liu S, Gupta A, Quarles LD., Emerging role of fibroblast growth factor 23 in a bone-kidney axis regulating systemic phosphate homeostasis and extracellular matrix mineralization. Curr Opin Nephrol Hypertens. 2007; 16: 329-335. (Pubitemid 46944331)
30. Ye L, MacDougall M, Zhang S, et al. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004; 279: 19141-19148. (Pubitemid 38623345)
31. Liu S, Zhou J, Tang W, Menard R, Feng JQ, Quarles LD., Pathogenic role of Fgf23 in Dmp1-null mice. Am J Physiol Endocrinol Metab. 2008; 295: E254-261.
32. Komaba H, Fukagawa M., FGF23-parathyroid interaction: implications in chronic kidney disease. Kidney Int. 2010; 77: 292-298.
33. Bergwitz C, Juppner H., Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23. Annu Rev Med. 2010; 61: 91-104.
34. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, et al. The parathyroid is a target organ for FGF23 in rats. J Clin Invest. 2007; 117: 4003-4008. (Pubitemid 350224109)
35. Anderson HC, Harmey D, Camacho NP, et al. Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice. Am J Pathol. 2005; 166: 1711-1720. (Pubitemid 40734394)
36. Anderson HC, Sipe JB, Hessle L, et al. Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice. Am J Pathol. 2004; 164: 841-847. (Pubitemid 38235466)
37. Hessle L, Johnson KA, Anderson HC, et al. Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A. 2002; 99: 9445-9449. (Pubitemid 34764633)