OSBP-Related Proteins (ORPs) in Human Adipose Depots and Cultured Adipocytes: Evidence for Impacts on the Adipocyte Phenotype

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Zhou, You ^a   Robciuc, Marius R ^b   Wabitsch, Martin ^c   Juuti, Anne ^d   Leivonen, Marja ^d   Ehnholm, Christian ^b   Yki Järvinen, Hannele ^a,e   Olkkonen, Vesa M ^a,f  

^a MINERVA FOUNDATION INSTITUTE FOR MEDICAL RESEARCH   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF ULM   (Germany)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e UNIVERSITY OF HELSINKI   (Finland)

^f UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CELL PROTEIN; MESSENGER RNA; OXYSTEROL BINDING PROTEIN RELATED PROTEIN; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 11; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 2; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 3; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 4; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 7; OXYSTEROL BINDING PROTEIN RELATED PROTEIN 8; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ADULT; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRAABDOMINAL FAT; LIPID STORAGE; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; SIMPSON GOLABI BEHMEL SYNDROME; SUBCUTANEOUS FAT;

ADIPOCYTES; ADIPONECTIN; ADULT; BLOTTING, WESTERN; CARRIER PROTEINS; CELL DIFFERENTIATION; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; FEMALE; HUMANS; MALE; MIDDLE AGED; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRIGLYCERIDES;

EID: 84866698576     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045352     Document Type: Article

References (60)

1. Olkkonen VM, Lehto M, (2004) Oxysterols and oxysterol binding proteins: Role in lipid metabolism and atherosclerosis. Ann Med 36: 562-572.
2. Cowart LA, (2009) Sphingolipids: Players in the pathology of metabolic disease. Trends Endocrinol Metab 20: 34-42.
3. Nagao K, Yanagita T, (2008) Bioactive lipids in metabolic syndrome. Prog Lipid Res 47: 127-146.
4. Bjorkhem I, Diczfalusy U, (2002) Oxysterols: Friends, foes, or just fellow passengers? Arterioscler Thromb Vasc Biol 22: 734-742.
5. Lordan S, O'Brien NM, Mackrill JJ, (2009) The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide. J Biochem Mol Toxicol 23: 324-332.
6. Olkkonen VM, Béaslas O, Nissilä E, (2012) Oxysterols and their cellular effectors Biomolecules. 2: 76-103.
7. Burgett AW, Poulsen TB, Wangkanont K, Anderson DR, Kikuchi C, et al. (2011) Natural products reveal cancer cell dependence on oxysterol-binding proteins. Nat Chem Biol 7: 639-647.
8. Arca M, Natoli S, Micheletta F, Riggi S, Di Angelantonio E, et al. (2007) Increased plasma levels of oxysterols, in vivo markers of oxidative stress, in patients with familial combined hyperlipidemia: Reduction during atorvastatin and fenofibrate therapy. Free Radic Biol Med 42: 698-705.
9. Ferderbar S, Pereira EC, Apolinario E, Bertolami MC, Faludi A, et al. (2007) Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus. Diabetes Metab Res Rev 23: 35-42.
10. Alkazemi D, Egeland G, Vaya J, Meltzer S, Kubow S, (2008) Oxysterol as a marker of atherogenic dyslipidemia in adolescence. J Clin Endocrinol Metab 93: 4282-4289.
11. Szuchman A, Aviram M, Musa R, Khatib S, Vaya J, (2008) Characterization of oxidative stress in blood from diabetic vs. hypercholesterolaemic patients, using a novel synthesized marker. Biomarkers 13: 119-131.
12. Zieden B, Kaminskas A, Kristenson M, Kucinskiene Z, Vessby B, et al. (1999) Increased plasma 7 beta-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. Arterioscler Thromb Vasc Biol 19: 967-971.
13. Bays HE, (2009) "Sick fat," metabolic disease, and atherosclerosis. Am J Med 122: S26-37.
14. Wamil M, Andrew R, Chapman KE, Street J, Morton NM, et al. (2008) 7-oxysterols modulate glucocorticoid activity in adipocytes through competition for 11beta-hydroxysteroid dehydrogenase type. Endocrinology 149: 5909-5918.
15. Kha HT, Basseri B, Shouhed D, Richardson J, Tetradis S, et al. (2004) Oxysterols regulate differentiation of mesenchymal stem cells: Pro-bone and anti-fat. J Bone Miner Res 19: 830-840.
16. Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, et al. (2007) Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem 282: 8959-8968.
17. Kim WK, Meliton V, Amantea CM, Hahn TJ, Parhami F, (2007) 20(S)-hydroxycholesterol inhibits PPARgamma expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism. J Bone Miner Res 22: 1711-1719.
18. Johnson JS, Meliton V, Kim WK, Lee KB, Wang JC, et al. (2011) Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo. J Cell Biochem 112: 1673-1684.
19. Baranova A, Collantes R, Gowder SJ, Elariny H, Schlauch K, et al. (2005) Obesity-related differential gene expression in the visceral adipose tissue. Obes Surg 15: 758-765.
20. Inoue Y, Yu AM, Yim SH, Ma X, Krausz KW, et al. (2006) Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4alpha. J Lipid Res 47: 215-227.
21. Canagarajah BJ, Hummer G, Prinz WA, Hurley JH, (2008) Dynamics of cholesterol exchange in the oxysterol binding protein family. J Mol Biol 378: 737-748.
22. de Saint-Jean M, Delfosse V, Douguet D, Chicanne G, Payrastre B, et al. (2011) Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J Cell Biol 195: 965-978.
23. Yan D, Olkkonen VM, (2008) Characteristics of oxysterol binding proteins. Int Rev Cytol 265: 253-285.
24. Perry RJ, Ridgway ND, (2006) Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein. Mol Biol Cell 17: 2604-2616.
25. Banerji S, Ngo M, Lane CF, Robinson CA, Minogue S, et al. (2010) Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the golgi apparatus requires phosphatidylinositol 4-kinase IIalpha. Mol Biol Cell 21: 4141-4150.
26. Wang PY, Weng J, Anderson RG, (2005) OSBP is a cholesterol-regulated scaffolding protein in control of ERK 1/2 activation. Science 307: 1472-1476.
27. Yan D, Lehto M, Rasilainen L, Metso J, Ehnholm C, et al. (2007) Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis. Arterioscler Thromb Vasc Biol 27: 1108-1114.
28. Olkkonen VM, Zhou Y, Yan D, Vihervaara T, (2012) Oxysterol-binding proteins-emerging roles in cell regulation Eur J Lipid Sci Technol. 114: 634-643.
29. Ngo MH, Colbourne TR, Ridgway ND, (2010) Functional implications of sterol transport by the oxysterol-binding protein gene family. Biochem J 429: 13-24.
30. Raychaudhuri S, Prinz WA, (2010) The diverse functions of oxysterol-binding proteins. Annu Rev Cell Dev Biol 26: 157-177.
31. Jordan SD, Kruger M, Willmes DM, Redemann N, Wunderlich FT, et al. (2011) Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat Cell Biol 13: 434-446.
32. Zhou T, Li S, Zhong W, Vihervaara T, Beaslas O, et al. (2011) OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62. PLoS One 6: e21078.
33. Bouchard L, Faucher G, Tchernof A, Deshaies Y, Marceau S, et al. (2009) Association of OSBPL11 gene polymorphisms with cardiovascular disease risk factors in obesity. Obesity 17: 1466-1472.
34. Bouchard L, Rabasa-Lhoret R, Faraj M, Lavoie ME, Mill J, et al. (2010) Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction. Am J Clin Nutr 91: 309-320.
35. Wabitsch M, Brenner RE, Melzner I, Braun M, Moller P, et al. (2001) Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 25: 8-15.
36. Fischer-Posovszky P, Newell FS, Wabitsch M, Tornqvist HE, (2008) Human SGBS cells- a unique tool for studies of human fat cell biology. Obes Facts 1: 184-189.
37. Laitinen S, Lehto M, Lehtonen S, Hyvärinen K, Heino S, et al. (2002) ORP2, a homolog of oxysterol binding protein, regulates cellular cholesterol metabolism. J Lipid Res 43: 245-255.
38. Lehto M, Tienari J, Lehtonen S, Lehtonen E, Olkkonen VM, (2004) Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: The expression and intracellular localization of ORP3, ORP6, and ORP7. Cell Tissue Res 315: 39-57.
39. Yan D, Mäyränpää MI, Wong J, Perttilä J, Lehto M, et al. (2008) OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages. J Biol Chem 283: 332-340.
40. Zhou Y, Li S, Mäyränpää MI, Zhong W, Bäck N, et al. (2010) OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the golgi-late endosome interface. Exp Cell Res 316: 3304-3316.
41. Lehto M, Mäyränpää MI, Pellinen T, Ihalmo P, Lehtonen S, et al. (2008) The R-ras interaction partner ORP3 regulates cell adhesion. J Cell Sci 121: 695-705.
42. Johansson M, Bocher V, Lehto M, Chinetti G, Kuismanen E, et al. (2003) The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct. Mol Biol Cell 14: 903-915.
43. Jansen M, Ohsaki Y, Rita Rega L, Bittman R, Olkkonen VM, et al. (2011) Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells. Traffic 12: 218-231.
44. Gimeno RE, Klaman LD, (2005) Adipose tissue as an active endocrine organ: Recent advances. Curr Opin Pharmacol 5: 122-128.
45. Lehto M, Laitinen S, Chinetti G, Johansson M, Ehnholm C, et al. (2001) The OSBP-related protein family in humans. J Lipid Res 42: 1203-1213.
46. Jaworski CJ, Moreira E, Li A, Lee R, Rodriguez IR, (2001) A family of 12 human genes containing oxysterol-binding domains. Genomics 78: 185-196.
47. Ngo M, Ridgway ND, (2009) Oxysterol binding protein-related protein 9 (ORP9) is a cholesterol transfer protein that regulates golgi structure and function. Mol Biol Cell 20: 1388-1399.
48. Lago F, Dieguez C, Gomez-Reino J, Gualillo O, (2007) Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 3: 716-724.
49. Amri EZ, Bertrand B, Ailhaud G, Grimaldi P, (1991) Regulation of adipose cell differentiation. I. fatty acids are inducers of the aP2 gene expression. J Lipid Res 32: 1449-1456.
50. Amri EZ, Ailhaud G, Grimaldi P, (1991) Regulation of adipose cell differentiation. II. kinetics of induction of the aP2 gene by fatty acids and modulation by dexamethasone. J Lipid Res 32: 1457-1463.
51. Tilg H, Moschen AR, (2008) Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 14: 222-231.
52. Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, et al. (2007) Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: A 5-year prospective study. Circulation 115: 1537-1543.
53. Tso AW, Xu A, Sham PC, Wat NM, Wang Y, et al. (2007) Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: A 10-year prospective study in a chinese cohort. Diabetes Care 30: 2667-2672.
54. Cabre A, Babio N, Lazaro I, Bullo M, Garcia-Arellano A, et al. (2012) FABP4 predicts atherogenic dyslipidemia development. the PREDIMED study. Atherosclerosis 222: 229-234.
55. Sun S, Ji Y, Kersten S, Qi L, (2012) Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr 32: 261-286.
56. Beaslas O, Vihervaara T, Li J, Laurila PP, Yan D, et al. (2012) Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity. Exp Cell Res 318: 1933-1945.
57. Vihervaara T, Käkelä R, Liebisch G, Tarasov K, Schmitz G, et al. (2012) Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins. Biochimie. 10.1016/j.biochi.2012.05.004.
58. Lee HK, Lee BH, Park SA, Kim CW, (2006) The proteomic analysis of an adipocyte differentiated from human mesenchymal stem cells using two-dimensional gel electrophoresis. Proteomics 6: 1223-1229.
59. Tang QQ, Lane MD, (2012) Adipogenesis: From stem cell to adipocyte. Annu Rev Biochem 81: 715-736.
60. Hynynen R, Suchanek M, Spandl J, Back N, Thiele C, et al. (2009) OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids. J Lipid Res 50: 1305-1315.