메뉴 건너뛰기




Volumn 40, Issue 5, 2012, Pages 1042-1046

Genetic analysis of Parkinson's disease-linked leucine-rich repeat kinase 2

Author keywords

Aging; Autophagy; Dopamine D2 receptor; Dopamine neurotransmission; Leucine rich repeat kinase 2 (LRRK2); Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; AMPHETAMINE; CATECHOLAMINE; DOPAMINE 2 RECEPTOR; LEUCINE RICH REPEAT KINASE 2; LIPOFUSCIN; SMALL INTERFERING RNA; UBIQUITINATED PROTEIN; VESICULAR MONOAMINE TRANSPORTER 2;

EID: 84866667871     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20120112     Document Type: Review
Times cited : (15)

References (50)
  • 2
    • 8844250179 scopus 로고    scopus 로고
    • Protein kinases linked to the pathogenesis of Parkinson's disease
    • Shen, J. (2004) Protein kinases linked to the pathogenesis of Parkinson's disease. Neuron 44, 575-577
    • (2004) Neuron , vol.44 , pp. 575-577
    • Shen, J.1
  • 6
    • 28744453588 scopus 로고    scopus 로고
    • Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease
    • Skipper, L., Li, Y., Bonnard, C., Pavanni, R., Yih, Y., Chua, E., Sung, W.K., Tan, L., Wong, M.C., Tan, E.K. and Liu, J. (2005) Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease. Hum. Mol. Genet. 14, 3549-3556
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3549-3556
    • Skipper, L.1    Li, Y.2    Bonnard, C.3    Pavanni, R.4    Yih, Y.5    Chua, E.6    Sung, W.K.7    Tan, L.8    Wong, M.C.9    Tan, E.K.10    Liu, J.11
  • 13
    • 33846818834 scopus 로고    scopus 로고
    • GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
    • Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T. and Iwatsubo, T. (2007) GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry 46, 1380-1388
    • (2007) Biochemistry , vol.46 , pp. 1380-1388
    • Ito, G.1    Okai, T.2    Fujino, G.3    Takeda, K.4    Ichijo, H.5    Katada, T.6    Iwatsubo, T.7
  • 15
    • 33751256567 scopus 로고    scopus 로고
    • The familial Parkinsonism gene LRRK2 regulates neurite process morphology
    • MacLeod, D., Dowman, J., Hammond, R., Leete, T., Inoue, K. and Abeliovich, A. (2006) The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52, 587-593
    • (2006) Neuron , vol.52 , pp. 587-593
    • MacLeod, D.1    Dowman, J.2    Hammond, R.3    Leete, T.4    Inoue, K.5    Abeliovich, A.6
  • 18
    • 34248574535 scopus 로고    scopus 로고
    • Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
    • Lee, S.B., Kim, W., Lee, S. and Chung, J. (2007) Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Biochem. Biophys. Res. Commun. 358, 534-539
    • (2007) Biochem. Biophys. Res. Commun. , vol.358 , pp. 534-539
    • Lee, S.B.1    Kim, W.2    Lee, S.3    Chung, J.4
  • 24
    • 66149087730 scopus 로고    scopus 로고
    • A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters
    • Robertson, S.D., Matthies, H.J. and Galli, A. (2009) A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters. Mol. Neurobiol. 39, 73-80
    • (2009) Mol. Neurobiol. , vol.39 , pp. 73-80
    • Robertson, S.D.1    Matthies, H.J.2    Galli, A.3
  • 26
    • 0035012078 scopus 로고    scopus 로고
    • Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells
    • Kantor, L., Hewlett, G.H., Park, Y.H., Richardson-Burns, S.M., Mellon, M.J. and Gnegy, M.E. (2001) Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells. J. Pharmacol. Exp. Ther. 297, 1016-1024
    • (2001) J. Pharmacol. Exp. Ther. , vol.297 , pp. 1016-1024
    • Kantor, L.1    Hewlett, G.H.2    Park, Y.H.3    Richardson-Burns, S.M.4    Mellon, M.J.5    Gnegy, M.E.6
  • 27
    • 76149134717 scopus 로고    scopus 로고
    • Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    • Li, X., Patel, J.C., Wang, J., Avshalumov, M.V., Nicholson, C., Buxbaum, J.D., Elder, G.A., Rice, M.E. and Yue, Z. (2010) Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S. J. Neurosci. 30, 1788-1797
    • (2010) J. Neurosci. , vol.30 , pp. 1788-1797
    • Li, X.1    Patel, J.C.2    Wang, J.3    Avshalumov, M.V.4    Nicholson, C.5    Buxbaum, J.D.6    Elder, G.A.7    Rice, M.E.8    Yue, Z.9
  • 33
    • 1542327580 scopus 로고    scopus 로고
    • Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease
    • Jenner, P. (2003) Dopamine agonists, receptor selectivity and dyskinesia induction in Parkinson's disease. Curr. Opin. Neurol. 16 (Suppl. 1), S3-S7
    • (2003) Curr. Opin. Neurol. , vol.16 , Issue.SUPPL. 1
    • Jenner, P.1
  • 34
    • 0034252558 scopus 로고    scopus 로고
    • The DRD2 gene in psychiatric and neurological disorders and its phenotypes
    • Noble, E.P. (2000) The DRD2 gene in psychiatric and neurological disorders and its phenotypes. Pharmacogenomics 1, 309-333
    • (2000) Pharmacogenomics , vol.1 , pp. 309-333
    • Noble, E.P.1
  • 38
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein
    • Giasson, B.I., Duda, J.E., Quinn, S.M., Zhang, B., Trojanowski, J.Q. and Lee, V.M. (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 34, 521-533
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 39
    • 0037173006 scopus 로고    scopus 로고
    • Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice
    • Lee, M.K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A.S., Dawson, T.M., Copeland, N.G., Jenkins, N.A. and Price, D.L. (2002) Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53→Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 99, 8968-8973
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 8968-8973
    • Lee, M.K.1    Stirling, W.2    Xu, Y.3    Xu, X.4    Qui, D.5    Mandir, A.S.6    Dawson, T.M.7    Copeland, N.G.8    Jenkins, N.A.9    Price, D.L.10
  • 40
    • 72149087091 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant α-synuclein
    • Lin, X., Parisiadou, L., Gu, X.L., Wang, L., Shim, H., Sun, L., Xie, C., Long, C.X., Yang, W.J., Ding, J. et al. (2009) Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease- related mutant α-synuclein. Neuron 64, 807-827
    • (2009) Neuron , vol.64 , pp. 807-827
    • Lin, X.1    Parisiadou, L.2    Gu, X.L.3    Wang, L.4    Shim, H.5    Sun, L.6    Xie, C.7    Long, C.X.8    Yang, W.J.9    Ding, J.10
  • 41
    • 77953090478 scopus 로고    scopus 로고
    • Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice
    • Tong, Y., Yamaguchi, H., Giaime, E., Boyle, S., Kopan, R., Kelleher, 3rd, R.J. and Shen, J. (2010) Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of α-synuclein, and apoptotic cell death in aged mice. Proc. Natl. Acad. Sci. U.S.A. 107, 9879-9884
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 9879-9884
    • Tong, Y.1    Yamaguchi, H.2    Giaime, E.3    Boyle, S.4    Kopan, R.5    Kelleher III, R.J.6    Shen, J.7
  • 46
    • 33747881231 scopus 로고    scopus 로고
    • Autophagy in neurodegenerative disease: Friend, foe or turncoat?
    • Nixon, R.A. (2006) Autophagy in neurodegenerative disease: friend, foe or turncoat? Trends Neurosci. 29, 528-535
    • (2006) Trends Neurosci. , vol.29 , pp. 528-535
    • Nixon, R.A.1
  • 47
    • 33750363298 scopus 로고    scopus 로고
    • The roles of intracellular protein-degradation pathways in neurodegeneration
    • Rubinsztein, D.C. (2006) The roles of intracellular protein-degradation pathways in neurodegeneration. Nature 443, 780-786
    • (2006) Nature , vol.443 , pp. 780-786
    • Rubinsztein, D.C.1
  • 48
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima, N., Yoshimori, T. and Levine, B. (2010) Methods in mammalian autophagy research. Cell 140, 313-326
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 49
    • 70349991886 scopus 로고    scopus 로고
    • LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    • Alegre-Abarrategui, J., Christian, H., Lufino, M.M., Mutihac, R., Venda, L.L., Ansorge, O. and Wade-Martins, R. (2009) LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 18, 4022-4034
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 4022-4034
    • Alegre-Abarrategui, J.1    Christian, H.2    Lufino, M.M.3    Mutihac, R.4    Venda, L.L.5    Ansorge, O.6    Wade-Martins, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.