A closer look at amphetamine-induced reverse transport and trafficking of the dopamine and norepinephrine transporters

Molecular Neurobiology

Volumn 39, Issue 2, 2009, Pages 73-80

  Robertson, S D ^a   Matthies, H J G ^a   Galli, A ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AMPH; Amphetamine; DAT; Dopamine transporter; Efflux; Monoamine transporter; Monoamines; NET; Neurotransmitter transporter; Norepinephrine transporter; Trafficking

Indexed keywords

AMPHETAMINE; DOPAMINE TRANSPORTER; MONOAMINE; NEUROTRANSMITTER; NORADRENALIN TRANSPORTER; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT;

CELL MEMBRANE; HUMAN; REGULATORY MECHANISM; REVIEW; STRUCTURE ANALYSIS; SYNAPSE VESICLE; DIFFUSION; DRUG EFFECT; METABOLISM; PHYSIOLOGY; SECOND MESSENGER; TRANSPORT AT THE CELLULAR LEVEL;

AMPHETAMINE; BIOLOGICAL TRANSPORT; DIFFUSION; DOPAMINE; DOPAMINE AGENTS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; HUMANS; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; SECOND MESSENGER SYSTEMS;

EID: 66149087730     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12035-009-8053-4     Document Type: Review

References (90)

1. D Sulzer MS Sonders NW Poulsen A Galli 2005 Mechanisms of neurotransmitter release by amphetamines: a review Prog Neurobiol 75 406 433 15955613 10.1016/j.pneurobio.2005.04.003 1:CAS:528:DC%2BD2MXlt1Kisr8%3D (Pubitemid 40834286)
2. M Prinzmetal W Bloomberg 1935 Use of benzedrine for the treatment of narcolepsy J Am Med Assoc 105 2051 2054 1:CAS:528:DyaA28XhtVylug%3D%3D
3. M Olfson SC Marcus MM Weissman PS Jensen 2002 National trends in the use of psychotropic medications by children J Am Acad Child Adolesc Psychiatry 41 514 521 12014783 10.1097/00004583-200205000-00008 (Pubitemid 38338129)
4. B Knutson, et al. 2004 Amphetamine modulates human incentive processing Neuron 43 261 269 15260961 10.1016/j.neuron.2004.06.030 1:CAS:528: DC%2BD2cXmslKrtLw%3D (Pubitemid 38942965)
5. AE Fleckenstein TJ Volz EL Riddle JW Gibb GR Hanson 2007 New insights into the mechanism of action of amphetamines Annu Rev Pharmacol Toxicol 47 681 698 17209801 10.1146/annurev.pharmtox.47.120505.105140 1:CAS:528: DC%2BD2sXit1alurs%3D (Pubitemid 46272143)
6. L Martinsson S Eksborg 2004 Drugs for stroke recovery: the example of amphetamines Drugs Aging 21 67 79 14960125 10.2165/00002512-200421020-00001 1:CAS:528:DC%2BD2cXislynsrk%3D (Pubitemid 38293787)
7. N Kirshner 1962 Uptake of catecholamines by a particulate fraction of the adrenal medulla J Biol Chem 237 2311 2317 14456353 1:CAS:528:DyaF38XksVGktb0%3D
8. A Carlsson NA Hillarp B Waldeck 1962 A Mg-ATP dependent storage mechanism in the amine granules of the adrenal medulla Med Exp Int J Exp Med 6 47 53 13876654 1:CAS:528:DyaF38XksVGru7w%3D
9. EA Fon, et al. 1997 Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action Neuron 19 1271 1283 9427250 10.1016/S0896-6273(00)80418-3 1:CAS:528:DyaK1cXitVahuw%3D%3D (Pubitemid 28030546)
10. JH Burn MJ Rand 1958 The action of sympathomimetic amines in animals treated with reserpine J Physiol 144 314 336 13611696 1:CAS:528: DyaG1MXlt1GjsQ%3D%3D
11. SR Jones RR Gainetdinov RM Wightman MG Caron 1998 Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter J Neurosci 18 1979 1986 9482784 1:CAS:528:DyaK1cXhs1yls74%3D
12. MC Ritz RJ Lamb SR Goldberg MJ Kuhar 1987 Cocaine receptors on dopamine transporters are related to self-administration of cocaine Science 237 1219 1223 2820058 10.1126/science.2820058 1:CAS:528:DyaL2sXls1yisr4%3D
13. D Sulzer, et al. 1995 Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport J Neurosci 15 4102 4108 7751968 1:CAS:528:DyaK2MXls1aitrg%3D
14. J Axelrod 1965 The metabolism, storage, and release of catecholamines Recent Prog Horm Res 21 597 622 14321067 1:CAS:528:DyaF2MXkvVajurk%3D
15. O Jardetzky 1966 Simple allosteric model for membrane pumps Nature 211 969 970 5968307 10.1038/211969a0 1:STN:280:CCiC2s3jvFU%3D
16. L Forrest, et al. 2008 Mechanism for alternating access in neurotransmitter transporters Proc Natl Acad Sci USA 105 10338 10343 18647834 10.1073/pnas.0804659105 1:CAS:528:DC%2BD1cXpsFKkt7c%3D
17. K Erreger C Grewer JA Javitch A Galli 2008 Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function J Neurosci 28 976 989 18216205 10.1523/JNEUROSCI.2796-07. 2008 1:CAS:528:DC%2BD1cXhs1Cmtbs%3D (Pubitemid 351158997)
18. + and substrate is triggered by substrate in a second binding site Mol Cell 30 667 677 18570870 10.1016/j.molcel.2008.05.008 1:CAS:528:DC%2BD1cXnvFWntrY%3D (Pubitemid 351815131)
19. +/Cl-dependent neurotransmitter transporters Nature 437 215 223 16041361 10.1038/nature03978 1:CAS:528:DC%2BD2MXpslekurY%3D (Pubitemid 41294479)
20. M Bruss R Hammermann S Brimijoin H Bonisch 1995 Antipeptide antibodies confirm the topology of the human norepinephrine transporter J Biol Chem 270 9197 9201 7721836 10.1074/jbc.270.16.9197 1:CAS:528:DyaK2MXlt1ajsbc%3D
21. SM Hersch H Yi CJ Heilman RH Edwards AI Levey 1997 Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra J Comp Neurol 388 211 227 9368838 10.1002/(SICI)1096- 9861(19971117)388:2<211::AID-CNE3>3.0.CO;2-4 1:CAS:528:DyaK2sXntFaku78%3D (Pubitemid 27471497)
22. JG Chen S Liu-Chen G Rudnick 1998 Determination of external loop topology in the serotonin transporter by site-directed chemical labeling J Biol Chem 273 12675 12681 9575231 10.1074/jbc.273.20.12675 1:CAS:528:DyaK1cXjtlSnsrk%3D (Pubitemid 28240647)
23. A Androutsellis-Theotokis G Rudnick 2002 Accessibility and conformational coupling in serotonin transporter predicted internal domains J Neurosci 22 8370 8378 12351711 1:CAS:528:DC%2BD38Xns1Cjurg%3D
24. C Granas J Ferrer CJ Loland JA Javitch U Gether 2003 N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization J Biol Chem 278 4990 5000 12464618 10.1074/jbc.M205058200 (Pubitemid 36801008)
25. H Khoshbouei, et al. 2004 N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux PLoS Biol 2 E78 15024426 10.1371/journal.pbio.0020078 (Pubitemid 39234535)
26. JU Fog, et al. 2006 Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport Neuron 51 417 429 16908408 10.1016/j.neuron.2006.06.028 1:CAS:528:DC%2BD28XovFKntbc%3D (Pubitemid 44219035)
27. LB Li, et al. 2004 The role of N-glycosylation in function and surface trafficking of the human dopamine transporter J Biol Chem 279 21012 21020 15024013 10.1074/jbc.M311972200 1:CAS:528:DC%2BD2cXjvV2ntr0%3D (Pubitemid 38656502)
28. JO Schenk 2002 The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate Prog Drug Res 59 111 131 12458965 1:CAS:528:DC%2BD38XpsVWisb8%3D
29. LS Seiden KE Sabol GA Ricaurte 1993 Amphetamine: effects on catecholamine systems and behavior Annu Rev Pharmacol Toxicol 33 639 677 8494354 10.1146/annurev.pa.33.040193.003231 1:CAS:528:DyaK3sXks1aitLc%3D
30. M Raiteri F Cerrito AM Cervoni G Levi 1979 Dopamine can be released by two mechanisms differentially affected by the dopamine transport inhibitor nomifensine J Pharmacol Exp Ther 208 195 202 216794 1:CAS:528:DyaE1MXhsVOisLY%3D
31. RE Heikkila H Orlansky C Mytilineou G Cohen 1975 Amphetamine: evaluation of d- and l-isomers as releasing agents and uptake inhibitors for 3H-dopamine and 3H-norepinephrine in slices of rat neostriatum and cerebral cortex J Pharmacol Exp Ther 194 47 56 1151755 1:CAS:528:DyaE2MXltVyiurY%3D
32. EM Parker LX Cubeddu 1988 Comparative effects of amphetamine, phenylethylamine and related drugs on dopamine efflux, dopamine uptake and mazindol binding J Pharmacol Exp Ther 245 199 210 3129549 1:CAS:528: DyaL1cXitFKhtrg%3D
33. JF Fischer AK Cho 1979 Chemical release of dopamine from striatal homogenates: evidence for an exchange diffusion model J Pharmacol Exp Ther 208 203 209 762652 1:CAS:528:DyaE1MXhsV2isbo%3D
34. WB Burnette, et al. 1996 Human norepinephrine transporter kinetics using rotating disk electrode voltammetry Anal Chem 68 2932 2938 8794928 10.1021/ac960022x 1:CAS:528:DyaK28XksFGrt7s%3D (Pubitemid 26305532)
35. R Zaczek S Culp EB De Souza 1991 Interactions of [3H]amphetamine with rat brain synaptosomes. II. Active transport J Pharmacol Exp Ther 257 830 835 1903446 1:CAS:528:DyaK3MXktVSks7c%3D
36. MS Sonders SJ Zhu NR Zahniser MP Kavanaugh SG Amara 1997 Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants J Neurosci 17 960 974 8994051 1:CAS:528:DyaK2sXos1yksQ%3D%3D
37. HH Sitte, et al. 1998 Carrier-mediated release, transport rates, and charge transfer induced by amphetamine, tyramine, and dopamine in mammalian cells transfected with the human dopamine transporter J Neurochem 71 1289 1297 9721755 1:CAS:528:DyaK1cXls1Khtbs%3D
38. +-dependent mechanism J Biol Chem 278 12070 12077 12556446 10.1074/jbc.M212815200 1:CAS:528:DC%2BD3sXisVOnsLw%3D (Pubitemid 36800184)
39. C Pifl EA Singer 1999 Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of facilitated exchange diffusion Mol Pharmacol 56 1047 1054 10531412 1:CAS:528:DyaK1MXntV2lsrY%3D
40. C Pifl P Rebernik A Kattinger H Reither 2004 Zn(2+) modulates currents generated by the dopamine transporter: parallel effects on amphetamine-induced charge transfer and release Neuropharmacology 46 223 231 14680760 10.1016/j.neuropharm.2003.09.007 1:CAS:528:DC%2BD3sXpvVWgsL8%3D (Pubitemid 37532830)
41. C Pifl H Drobny H Reither O Hornykiewicz EA Singer 1995 Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter Mol Pharmacol 47 368 373 7870046 1:CAS:528:DyaK2MXktVSlsbw%3D
42. - of cocaine sensitive carrier-mediated efflux of amines from cells transfected with the cloned human catecholamine transporters Br J Pharmacol 121 205 212 9154329 10.1038/sj.bjp.0701137 1:CAS:528: DyaK2sXjtFygtrw%3D
43. S Seidel, et al. 2005 Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action Mol Pharmacol 67 140 151 15615700 1:CAS:528:DC%2BD2MXlt12rtA%3D%3D
44. KM Kahlig, et al. 2005 Amphetamine induces dopamine efflux through a dopamine transporter channel Proc Natl Acad Sci USA 102 3495 3500 15728379 10.1073/pnas.0407737102 1:CAS:528:DC%2BD2MXitl2ksro%3D (Pubitemid 40328073)
45. HE Melikian KM Buckley 1999 Membrane trafficking regulates the activity of the human dopamine transporter J Neurosci 19 7699 7710 10479674 1:CAS:528:DyaK1MXlvFahsLY%3D
46. L Carvelli, et al. 2002 PI 3-kinase regulation of dopamine uptake J Neurochem 81 859 869 12065645 10.1046/j.1471-4159.2002.00892.x 1:CAS:528:DC%2BD38XktFCntbw%3D (Pubitemid 34809314)
47. MK Loder HE Melikian 2003 The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines J Biol Chem 278 22168 22174 12682063 10.1074/jbc.M301845200 1:CAS:528:DC%2BD3sXksVemurs%3D (Pubitemid 36792628)
48. CT Giambalvo 1992 Protein kinase C and dopamine transport-2 Effects of amphetamine in vitro. Neuropharmacology 31 1211 1222 1:CAS:528: DyaK3sXhtFKmtrc%3D
49. L Kantor ME Gnegy 1998 Protein kinase C inhibitors block amphetamine-mediated dopamine release in rat striatal slices J Pharmacol Exp Ther 284 592 598 9454802 1:CAS:528:DyaK1cXhtFWktr0%3D
50. RM Cowell L Kantor GH Hewlett KA Frey ME Gnegy 2000 Dopamine transporter antagonists block phorbol ester-induced dopamine release and dopamine transporter phosphorylation in striatal synaptosomes Eur J Pharmacol 389 59 65 10686296 10.1016/S0014-2999(99)00828-6 1:CAS:528:DC%2BD3cXht1OgtLo%3D (Pubitemid 30109367)
51. L Kantor, et al. 2001 Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells J Pharmacol Exp Ther 297 1016 1024 11356924 1:CAS:528:DC%2BD3MXjvVShsrw%3D
52. L Kantor M Zhang B Guptaroy YH Park ME Gnegy 2004 Repeated amphetamine couples norepinephrine transporter and calcium channel activities in PC12 cells J Pharmacol Exp Ther 311 1044 1051 15340003 10.1124/jpet.104.071068 1:CAS:528:DC%2BD2cXhtVKmtL3F (Pubitemid 39612710)
53. 2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter Mol Pharmacol 66 137 143 15213305 10.1124/mol.66.1.137 1:CAS:528:DC%2BD2cXlsVOju7o%3D (Pubitemid 38822096)
54. LA Johnson B Guptaroy D Lund S Shamban ME Gnegy 2005 Regulation of amphetamine-stimulated dopamine efflux by protein kinase C beta J Biol Chem 280 10914 10919 15647254 10.1074/jbc.M413887200 1:CAS:528:DC%2BD2MXisVOqtb8%3D (Pubitemid 40418392)
55. JD Foster B Pananusorn RA Vaughan 2002 Dopamine transporters are phosphorylated on N-terminal serines in rat striatum J Biol Chem 277 25178 25186 11994276 10.1074/jbc.M200294200 1:CAS:528:DC%2BD38XlsVWiur0%3D (Pubitemid 34951824)
56. 2+- and calmodulin-dependent phosphorylation and synaptic vesicles J Neurosci 19 3801 3808 10234012 1:CAS:528:DyaK1MXjtV2rtLo%3D
57. RC Pierce PW Kalivas 1997 Repeated cocaine modifies the mechanism by which amphetamine releases dopamine J Neurosci 17 3254 3261 9096158 1:CAS:528:DyaK2sXislahs74%3D
58. F Binda, et al. 2008 Syntaxin1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux Mol Pharmacol 74 1101 1108 18617632 10.1124/mol.108.048447 1:CAS:528:DC%2BD1cXht1Sgtb%2FL
59. C Dipace U Sung F Binda RD Blakely A Galli 2007 Amphetamine induces a calcium/calmodulin-dependent protein kinase II-dependent reduction in norepinephrine transporter surface expression linked to changes in syntaxin 1A/transporter complexes Mol Pharmacol 71 230 239 17032905 10.1124/mol.106. 026690 1:CAS:528:DC%2BD2sXit1GqtA%3D%3D (Pubitemid 46020993)
60. U Sung, et al. 2003 A regulated interaction of syntaxin 1A with the antidepressant- sensitive norepinephrine transporter establishes catecholamine clearance capacity J Neurosci 23 1697 709 12629174 1:CAS:528: DC%2BD3sXjtFyltLc%3D
61. L Carvelli RD Blakely LJ DeFelice 2008 Dopamine transporter/syntaxin 1A interactions regulate transporter channel activity and dopaminergic synaptic transmission Proc Natl Acad Sci USA 105 14192 14197 18768815 10.1073/pnas.0802214105 1:CAS:528:DC%2BD1cXhtFKjsb7E
62. AE Fleckenstein RR Metzger DG Wilkins JW Gibb GR Hanson 1997 Rapid and reversible effects of methamphetamine on dopamine transporters J Pharmacol Exp Ther 282 834 838 9262348 1:CAS:528:DyaK2sXltlSntbk%3D
63. C Saunders, et al. 2000 Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism Proc Natl Acad Sci USA 97 6850 6855 10823899 10.1073/pnas.110035297 1:CAS:528:DC%2BD3cXktFahsL8%3D (Pubitemid 30412803)
64. KM Kahlig A Galli 2003 Regulation of dopamine transporter function and plasma membrane expression by dopamine, amphetamine, and cocaine Eur J Pharmacol 479 153 158 14612146 10.1016/j.ejphar.2003.08.065 1:CAS:528: DC%2BD3sXovVGntb8%3D (Pubitemid 37377884)
65. KM Kahlig JA Javitch A Galli 2004 Amphetamine regulation of dopamine transport. Combined measurements of transporter currents and transporter imaging support the endocytosis of an active carrier J Biol Chem 279 8966 8975 14699142 10.1074/jbc.M303976200 1:CAS:528:DC%2BD2cXhs1Onu74%3D (Pubitemid 38295958)
66. KM Kahlig, et al. 2006 Regulation of dopamine transporter trafficking by intracellular amphetamine Mol Pharmacol 70 542 548 16684900 10.1124/mol.106. 023952 1:CAS:528:DC%2BD28Xnslyjsrs%3D (Pubitemid 44092315)
67. L Chi ME Reith 2003 Substrate-induced trafficking of the dopamine transporter in heterologously expressing cells and in rat striatal synaptosomal preparations J Pharmacol Exp Ther 307 729 736 12975490 10.1124/jpet.103.055095 1:CAS:528:DC%2BD3sXos1Shs7c%3D (Pubitemid 37310690)
68. JM Gulley S Doolen NR Zahniser 2002 Brief, repeated exposure to substrates down-regulates dopamine transporter function in Xenopus oocytes in vitro and rat dorsal striatum in vivo J Neurochem 83 400 411 12423250 10.1046/j.1471-4159.2002.01133.x 1:CAS:528:DC%2BD38XotFyltbk%3D (Pubitemid 35191405)
69. WA Owens, et al. 2005 Deficits in dopamine clearance and locomotion in hypoinsulinemic rats unmask novel modulation of dopamine transporters by amphetamine J Neurochem 94 1402 1410 15992364 10.1111/j.1471-4159.2005.03289.x 1:CAS:528:DC%2BD2MXpvF2qu7k%3D (Pubitemid 41232595)
70. JM Williams, et al. 2007 Hypoinsulinemia regulates amphetamine-induced reverse transport of dopamine PLoS Biol 5 2369 2378 10.1371/journal.pbio.0050274 1:CAS:528:DC%2BD2sXhsVersrvN (Pubitemid 350035435)
71. LA Johnson CA Furman M Zhang B Guptaroy ME Gnegy 2005 Rapid delivery of the dopamine transporter to the plasmalemmal membrane upon amphetamine stimulation Neuropharmacology 49 750 758 16212991 10.1016/j.neuropharm.2005.08. 018 1:CAS:528:DC%2BD2MXhtFehs7fI (Pubitemid 41483881)
72. ZB Pristupa, et al. 1998 Protein kinase-mediated bidirectional trafficking and functional regulation of the human dopamine transporter Synapse 30 79 87 9704884 10.1002/(SICI)1098-2396(199809)30:1<79::AID-SYN10>3.0. CO;2-K 1:CAS:528:DyaK1cXltVKqs78%3D (Pubitemid 28361186)
73. GM Daniels SG Amara 1999 Regulated trafficking of the human dopamine transporter. Clathrin-mediated internalization and lysosomal degradation in response to phorbol esters J Biol Chem 274 35794 35801 10585462 10.1074/jbc.274.50.35794 1:STN:280:DC%2BD3c%2FlsVCltg%3D%3D
74. T Sorkina S Doolen E Galperin NR Zahniser A Sorkin 2003 Oligomerization of dopamine transporters visualized in living cells by fluorescence resonance energy transfer microscopy J Biol Chem 278 28274 28283 12746456 10.1074/jbc.M210652200 1:CAS:528:DC%2BD3sXlsFKrsb8%3D (Pubitemid 36900029)
75. MA Cervinski JD Foster RA Vaughan 2005 Psychoactive substrates stimulate dopamine transporter phosphorylation and down regulation by cocaine sensitive and protein kinase C dependent mechanisms J Biol Chem 280 40442 40449 16204245 10.1074/jbc.M501969200 1:CAS:528:DC%2BD2MXht1OqtrjL (Pubitemid 41780531)
76. E Boudanova DM Navaroli Z Stevens HE Melikian 2008 Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization Mol Cell Neurosci 39 211 217 18638559 10.1016/j.mcn.2008.06.011 1:CAS:528:DC%2BD1cXhtFCnsr%2FE
77. E Boudanova DM Navaroli HE Melikian 2008 Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent Neuropharmacology 54 605 612 18164041 10.1016/j.neuropharm.2007.11.007 1:CAS:528:DC%2BD1cXhsVSgtL4%3D
78. JD Foster SD Adkins JR Lever RA Vaughan 2008 Phorbol ester induced trafficking-independent regulation and enhanced phosphorylation of the dopamine transporter associated with membrane rafts and cholesterol J Neurochem 105 1683 1699 18248623 10.1111/j.1471-4159.2008.05262.x 1:CAS:528:DC%2BD1cXntVCksbg%3D (Pubitemid 351678491)
79. 2+/calmodulin- dependent kinase II-dependent mechanism Mol Pharmacol 71 835 842 17164407 10.1124/mol.106.026351 1:CAS:528:DC%2BD2sXis1aquro%3D (Pubitemid 46294095)
80. PC Chu MT Lin LR Shian SY Leu 1986 Alterations in physiologic functions and in brain monoamine content in streptozocin-diabetic rats Diabetes 35 481 485 3514326 10.2337/diabetes.35.4.481 1:CAS:528:DyaL28XitVCrurk%3D
81. A Saitoh K Morita M Sodeyama J Kamei 1998 Effects of the experimental diabetes on dopamine D1 receptor-mediated locomotor-enhancing activity in mice Pharmacol Biochem Behav 60 161 166 9610938 10.1016/S0091-3057(97)00588-1 1:CAS:528:DyaK1cXjtVCjtL0%3D (Pubitemid 28236626)
82. GB Karkanias JC Morales CS Li 1997 Deficits in reproductive behavior in diabetic female rats are due to hypoinsulinemia rather than hyperglycemia Horm Behav 32 19 29 9344688 10.1006/hbeh.1997.1401 1:CAS:528:DyaK2sXntFCktrY%3D (Pubitemid 27465905)
83. S Doolen NR Zahniser 2001 Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes J Pharmacol Exp Ther 296 931 938 11181926 1:CAS:528:DC%2BD3MXhtlOks70%3D
84. BG Garcia, et al. 2005 Akt is essential for insulin modulation of amphetamine-induced human dopamine transporter cell-surface redistribution Mol Pharmacol 68 102 109 15795321 1:CAS:528:DC%2BD2MXlvVSqtbY%3D
85. R Galici, et al. 2003 Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats Neuroendocrinology 77 132 140 12624535 10.1159/000068650 1:CAS:528:DC%2BD3sXhvFyit78%3D (Pubitemid 36302415)
86. BJ Lute, et al. 2008 PI3K signaling supports amphetamine-induced dopamine efflux Biochem Biophys Res Commun 372 656 661 18510945 10.1016/j.bbrc.2008.05. 091 1:CAS:528:DC%2BD1cXns1Sgs7c%3D
87. MY Zhu S Shamburger J Li GA Ordway 2000 Regulation of the human norepinephrine transporter by cocaine and amphetamine J Pharmacol Exp Ther 295 951 959 11082428 1:CAS:528:DC%2BD3cXosVKisrs%3D
88. LD Jayanthi B Annamalai DJ Samuvel U Gether S Ramamoorthy 2006 Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization J Biol Chem 281 23326 23340 16740633 10.1074/jbc.M601156200 1:CAS:528: DC%2BD28XotVCmtr0%3D (Pubitemid 44274107)
89. LD Jayanthi DJ Samuvel S Ramamoorthy 2004 Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters. evidence for localization in lipid rafts and lipid raft-mediated internalization J Biol Chem 279 19315 19326 14976208 10.1074/jbc.M311172200 1:CAS:528:DC%2BD2cXjsVKmurc%3D (Pubitemid 38623363)
90. MS Mazei-Robison, et al. 2008 Anomalous dopamine release associated with a human dopamine transporter coding variant J Neurosci 28 7040 7046 18614672 10.1523/JNEUROSCI.0473-08.2008 1:CAS:528:DC%2BD1cXovVSgt70%3D