Targeting C/EBP homologous protein with siRNA attenuates cerebral vasospasm after experimental subarachnoid hemorrhage

Experimental Neurology

Volumn 238, Issue 2, 2012, Pages 218-224

  He, Zhaohui ^a,b   Ostrowski, Robert P ^b,c   Sun, Xiaochuan ^a   Ma, Qingyi ^b,d   Tang, Jiping ^b,d   Zhang, John H ^a,b,d  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^d LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bcl 2; Bim; C EBP homologous protein; Caspase 3; Cerebral vasospasm; SiRNA; Subarachnoid hemorrhage

Indexed keywords

BIM PROTEIN; C EBP HOMOLOGOUS PROTEIN; CASPASE 3; CELL PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD VESSEL PERFORATION; BRAIN VASOSPASM; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESPONSE; DRUG TARGETING; ENDOTHELIUM CELL; MALE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE; UPREGULATION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BASILAR ARTERY; CASPASE 3; CELL COUNT; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENDOTHELIUM; IN SITU NICK-END LABELING; MALE; MEMBRANE PROTEINS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SUBARACHNOID HEMORRHAGE; TRANSCRIPTION FACTOR CHOP; VASOSPASM, INTRACRANIAL; VON WILLEBRAND FACTOR;

EID: 84866642228     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2012.08.025     Document Type: Article

References (36)

1. Behlke M.A. Progress towards in vivo use of siRNAs. Mol. Ther. 2006, 13:644-670.
2. Bendel P., Koivisto T., Hanninen T., Kolehmainen A., Kononen M., Hurskainen H., Pennanen C., Vanninen R. Subarachnoid hemorrhage is followed by temporomesial volume loss: MRI volumetric study. Neurology 2006, 67:575-582.
3. Blaschke F., Bruemmer D., Yin F., Takata Y., Wang W., Fishbein M.C., Okura T., Higaki J., Graf K., Fleck E., Hsueh W.A., Law R.E. C-reactive protein induces apoptosis in human coronary vascular smooth muscle cells. Circulation 2004, 110:579-587.
4. Chen G., Zhang S., Shi J., Ai J., Hang C. Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine 2009, 45:162-168.
5. Cheng G., Wei L., Zhi-Dan S., Shi-Guang Z., Xiang-Zhen L. Atorvastatin ameliorates cerebral vasospasm and early brain injury after subarachnoid hemorrhage and inhibits caspase-dependent apoptosis pathway. BMC Neurosci. 2009, 10:7.
6. Endo H., Murata K., Mukai M., Ishikawa O., Inoue M. Activation of insulin-like growth factor signaling induces apoptotic cell death under prolonged hypoxia by enhancing endoplasmic reticulum stress response. Cancer Res. 2007, 67:8095-8103.
7. Fathali N., Ostrowski R.P., Lekic T., Jadhav V., Tong W., Tang J., Zhang J.H. Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury. Crit. Care Med. 2010, 38:572-578.
8. Frykholm P., Andersson J.L., Langstrom B., Persson L., Enblad P. Haemodynamic and metabolic disturbances in the acute stage of subarachnoid haemorrhage demonstrated by PET. Acta Neurol. Scand. 2004, 109:25-32.
9. Gotoh T., Terada K., Oyadomari S., Mori M. hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 2004, 11:390-402.
10. He Z., Ostrowski R.P., Sun X., Ma Q., Huang B., Zhan Y., Zhang J.H. CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage. Stroke 2012, 43:484-490.
11. Heath-Engel H.M., Chang N.C., Shore G.C. The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family. Oncogene 2008, 27:6419-6433.
12. Hetz C.A. ER stress signaling and the BCL-2 family of proteins: from adaptation to irreversible cellular damage. Antioxid. Redox Signal. 2007, 9:2345-2355.
13. Jeon H., Ai J., Sabri M., Tariq A., Shang X., Chen G., Macdonald R.L. Neurological and neurobehavioral assessment of experimental subarachnoid hemorrhage. BMC Neurosci. 2009, 10:103.
14. Li L., Khatibi N.H., Hu Q., Yan J., Chen C., Han J., Ma D., Chen Y., Zhou C. Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats. Exp. Neurol. 2012, 234:181-190.
15. Lobovkina T., Jacobson G.B., Gonzalez-Gonzalez E., Hickerson R.P., Leake D., Kaspar R.L., Contag C.H., Zare R.N. In vivo sustained release of siRNA from solid lipid nanoparticles. ACS Nano 2011, 5:9977-9983.
16. Ma Y., Brewer J.W., Diehl J.A., Hendershot L.M. Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein response. J. Mol. Biol. 2002, 318:1351-1365.
17. Ma Q., Manaenko A., Khatibi N.H., Chen W., Zhang J.H., Tang J. Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice. J. Cereb. Blood Flow Metab. 2011, 31:881-893.
18. Matchett G.A., Calinisan J.B., Matchett G.C., Martin R.D., Zhang J.H. The effect of granulocyte-colony stimulating factor in global cerebral ischemia in rats. Brain Res. 2007, 1136:200-207.
19. Matsumoto M., Minami M., Takeda K., Sakao Y., Akira S. Ectopic expression of CHOP (GADD153) induces apoptosis in M1 myeloblastic leukemia cells. FEBS Lett. 1996, 395:143-147.
20. McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol. Cell. Biol. 2001, 21:1249-1259.
21. O'Connor L., Strasser A., O'Reilly L.A., Hausmann G., Adams J.M., Cory S., Huang D.C. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J. 1998, 17:384-395.
22. Ostrowski R.P., Colohan A.R., Zhang J.H. Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage. J. Cereb. Blood Flow Metab. 2005, 25:554-571.
23. Oyadomari S., Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004, 11:381-389.
24. Puthalakath H., O'Reilly L.A., Gunn P., Lee L., Kelly P.N., Huntington N.D., Hughes P.D., Michalak E.M., McKimm-Breschkin J., Motoyama N., Gotoh T., Akira S., Bouillet P., Strasser A. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007, 129:1337-1349.
25. Sercombe R., Dinh Y.R., Gomis P. Cerebrovascular inflammation following subarachnoid hemorrhage. Jpn. J. Pharmacol. 2002, 88:227-249.
26. Suzuki H., Sozen T., Hasegawa Y., Chen W., Zhang J.H. Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice. Stroke 2009, 40:3872-3875.
27. Suzuki H., Hasegawa Y., Chen W., Kanamaru K., Zhang J.H. Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage. Ann. Neurol. 2010, 68:650-660.
28. Sviri G.E., Newell D.W., Lewis D.H., Douville C., Ghodke B., Chowdhary M., Lam A.M., Haynor D., Zaaroor M., Britz G.W. Impact of basilar artery vasospasm on outcome in patients with severe cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke 2006, 37:2738-2743.
29. Szegezdi E., Macdonald D.C., Ni Chonghaile T., Gupta S., Samali A. Bcl-2 family on guard at the ER. Am. J. Physiol. Cell Physiol. 2009, 296:C941-C953.
30. Takata K., Sheng H., Borel C.O., Laskowitz D.T., Warner D.S., Lombard F.W. Long-term cognitive dysfunction following experimental subarachnoid hemorrhage: new perspectives. Exp. Neurol. 2008, 213:336-344.
31. Yan J.H., Yang X.M., Chen C.H., Hu Q., Zhao J., Shi X.Z., Luan L.J., Yang L., Qin L.H., Zhou C.M. Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat. Chin. Med. J. 2008, 121:414-419.
32. Yan J., Li L., Khatibi N.H., Yang L., Wang K., Zhang W., Martin R.D., Han J., Zhang J., Zhou C. Blood-brain barrier disruption following subarchnoid hemorrhage may be faciliated through PUMA induction of endothelial cell apoptosis from the endoplasmic reticulum. Exp. Neurol. 2011, 230:240-247.
33. Zhang K., Kaufman R.J. From endoplasmic-reticulum stress to the inflammatory response. Nature 2008, 454:455-462.
34. Zhang H., Li Q., Li Z., Mei Y., Guo Y. The protection of Bcl-2 overexpression on rat cortical neuronal injury caused by analogous ischemia/reperfusion in vitro. Neurosci. Res. 2008, 62:140-146.
35. Zhou C., Yamaguchi M., Colohan A.R., Zhang J.H. Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage. J. Cereb. Blood Flow Metab. 2005, 25:572-582.
36. 2+ in subarachnoid hemorrhage-induced spasm of the rabbit basilar artery. Stroke 1996, 27:1896-1902.