Influence of environmental and genetic factors on CYP1A2 activity in individuals of south Asian and European ancestry

Clinical Pharmacology and Therapeutics

Volumn 92, Issue 4, 2012, Pages 511-519

  Perera, V ^a,b   Gross, A S ^a,c   McLachlan, A J ^a,b  

^a UNIVERSITY OF SYDNEY   (Australia)

^b ANZAC Research Institute   (Australia)

^c GLAXOSMITHKLINE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CYTOCHROME P450 1A2; ORAL CONTRACEPTIVE AGENT; PARAXANTHINE; TRANSCRIPTION FACTOR HOXA10;

ADULT; ARTICLE; BEVERAGE; BROCCOLI; CABBAGE; CAULIFLOWER; COFFEE; CORIANDER; CUMIN; CURRY DIET; DIET; DNA POLYMORPHISM; ENERGY DRINK; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; ENZYME INHIBITION; ETHNICITY; EUROPE; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; GRAPEFRUIT JUICE; HEALTH SURVEY; HEREDITY; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MEAT; METABOLISM; ORAL CONTRACEPTION; PARSLEY; PRIORITY JOURNAL; SALIVA; SEX DIFFERENCE; SMOKING; SOFT DRINK; SOUTH ASIA; TEA;

ADOLESCENT; ADULT; ASIA, WESTERN; ASIAN CONTINENTAL ANCESTRY GROUP; AUSTRALIA; CROSS-SECTIONAL STUDIES; CYTOCHROME P-450 CYP1A2; ENVIRONMENT; ENZYME ACTIVATION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HUMANS; INDIA; LIFE STYLE; MALE; PROSPECTIVE STUDIES; SRI LANKA; YOUNG ADULT;

EID: 84866628464     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.139     Document Type: Article

References (50)

1. Gunes, A. & Dahl, M.L. Variation in cYP1A2 activity and its clinical implications: infuence of environmental factors and genetic polymorphisms. Pharmacogenomics 9, 625-637 (2008).
2. Aklillu, E. et al. Genetic polymorphism of cYP1A2 in Ethiopians afecting induction and expression: characterization of novel haplotypes with single-nucleotide polymorphisms in intron 1. Mol. Pharmacol. 64, 659-669 (2003).
3. Djordjevic, N., Ghotbi, R., Bertilsson, L., Jankovic, S. & Aklillu, E. Induction of cYP1A2 by heavy cofee consumption in Serbs and Swedes. Eur. J. Clin. Pharmacol. 64, 381-385 (2008).
4. Ghotbi, R., Christensen, M., Roh, H.K., Ingelman-Sundberg, M., Aklillu, E. & Bertilsson, L. comparisons of cYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans. Eur. J. Clin. Pharmacol. 63, 537-546 (2007).
5. Bertilsson, L. et al. clozapine disposition covaries with cYP1A2 activity determined by a cafeine test. Br. J. Clin. Pharmacol. 38, 471-473 (1994).
6. Shirley, K.L., Hon, Y.Y., Penzak, S.R., Lam, Y.W., Spratlin, V. & Jann, M.W. correlation of cytochrome P450 (cYP) 1A2 activity using cafeine phenotyping and olanzapine disposition in healthy volunteers. Neuropsychopharmacology 28, 961-966 (2003).
7. Rasmussen, B.B. & Brøsen, K. theophylline has no advantages over cafeine as a putative model drug for assessing cYPIA2 activity in humans. Br. J. Clin. Pharmacol. 43, 253-258 (1997).
8. Granfors, M.T., Backman, J.T., Laitila, J. & Neuvonen, P.J. Oral contraceptives containing ethinyl estradiol and gestodene markedly increase plasma concentrations and efects of tizanidine by inhibiting cytochrome P450 1A2. Clin. Pharmacol. Ther. 78, 400-411 (2005).
9. Peterson, S., Lampe, J.W., Bammler, t.K., Gross-Steinmeyer, K. & Eaton, D.L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hcYP1A2) activity and hcYP1A2-mediated mutagenicity of afatoxin B1. Food Chem. Toxicol. 44, 1474-1484 (2006).
10. the Human cytochrome P450 (CYP) Allele Nomenclature Database http://www.cypalleles.ki.se/. Accessed April 25 2012.
11. Klein, K., Winter, S., Turpeinen, M., Schwab, M. & Zanger, U.M. Pathway-targeted Pharmacogenomics of cYP1A2 in Human Liver. Front. Pharmacol. I, 129 (2010).
12. Lim, J.S. et al. Pharmacogenetics of cYP1A2, novel polymorphisms and haplotypes in three distinct Asian populations. Drug Metab. Pharmacokinet. 25, 616-623 (2010).
13. Appiah-Opong, R., Commandeur, J.N., van Vugt-Lussenburg, B. & Vermeulen, N.P. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology 235, 83-91 (2007).
14. Majumder, P. P. the human genetic history of South Asia. Curr. Biol. 20, R184-R187 (2010).
15. Abernethy, D.R. & todd, E.L. Impairment of cafeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur. J. Clin. Pharmacol. 28, 425-428 (1985).
16. Dobrinas, M., Cornuz, J., Oneda, B., Kohler Serra, M., Puhl, M. & Eap, C.B. Impact of smoking, smoking cessation, and genetic polymorphisms on cYP1A2 activity and inducibility. Clin. Pharmacol. Ther. 90, 117-125 (2011).
17. Brøsen, K., Skjelbo, E., Rasmussen, B.B., Poulsen, H.E. & Loft, S. Fluvoxamine is a potent inhibitor of cytochrome P4501A2. Biochem. Pharmacol. 45, 1211-1214 (1993).
18. Peterson, S. et al. cYP1A2, GStM1, and GStt1 polymorphisms and diet efects on cYP1A2 activity in a crossover feeding trial. Cancer Epidemiol. Biomarkers Prev. 18, 3118-3125 (2009).
19. Lampe, J.W. et al. Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in cafeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis 21, 1157-1162 (2000).
20. Lampe, J.W. & Peterson, S. Brassica, biotransformation and cancer risk: genetic polymorphisms alter the preventive efects of cruciferous vegetables. J. Nutr. 132, 2991-2994 (2002).
21. McDanell, R.E., Henderson, L.A., Russell, K. & McLean, A.E. the efect of brassica vegetable consumption on cafeine metabolism in humans. Hum. Exp. Toxicol. II, 167-172 (1992).
22. Murray, S. et al. Efect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man. Carcinogenesis 22, 1413-1420 (2001).
23. Walters, D.G. et al. cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in humans. Carcinogenesis 25, 1659-1669 (2004).
24. Fontana, R.J. et al. Efects of a chargrilled meat diet on expression of cYP3A, cYP1A, and P-glycoprotein levels in healthy volunteers. Gastroenterology 117, 89-98 (1999).
25. Conney, A.H. et al. Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin. Pharmacol. Ther. 20, 633-642 (1976).
26. Conney, A.H. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. clowes Memorial Lecture. Cancer Res. 42, 4875-4917 (1982).
27. Pantuck, E.J. et al. Efect of charcoal-broiled beef on phenacetin metabolism in man. Science 194, 1055-1057 (1976).
28. Pantuck, E.J. et al. Stimulatory efect of brussels sprouts and cabbage on human drug metabolism. Clin. Pharmacol. Ther. 25, 88-95 (1979).
29. Achaya, K.t. Indian Food: A Historical Companion (Oxford University Press, cary, Nc, 1994).
30. Delgado, C.L. Rising consumption of meat and milk in developing countries has created a new food revolution. J. Nutr. 133, 3907S-3910S (2003).
31. Gross-Steinmeyer, K. et al. Modulation of afatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols. Toxicol. Sci. 112, 303-310 (2009).
32. Gross-Steinmeyer, K. et al. Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. Xenobiotica. 34, 619-632 (2004).
33. Lake, B.G., Tredger, J.M., Renwick, A.B., Barton, P.t. & Price, R.J. 3,3′-Diindolylmethane induces cYP1A2 in cultured precision-cut human liver slices. Xenobiotica. 28, 803-811 (1998).
34. Hakooz, N. & Hamdan, I. Efects of dietary broccoli on human in vivo cafeine metabolism: a pilot study on a group of Jordanian volunteers. Curr. Drug Metab. 8, 9-15 (2007).
35. Kall, M.A., Vang, O. & clausen, J. Efects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of cafeine, oestrone and chlorzoxazone metabolism. Carcinogenesis 17, 793-799 (1996).
36. Kall, M.A., Vang, O. & clausen, J. Efects of dietary broccoli on human drug metabolising activity. Cancer Lett. 114, 169-170 (1997).
37. Vistisen, K., Loft, S. & Poulsen, H.E. cytochrome P450 IA2 activity in man measured by cafeine metabolism: efect of smoking, broccoli and exercise. Adv. Exp. Med. Biol. 283, 407-411 (1991).
38. Caraco, Y., Zylber-Katz, E., Granit, L. & Levy, M. Does restriction of cafeine intake afect mixed function oxidase activity and cafeine metabolism? Biopharm. Drug Dispos. 11, 639-643 (1990).
39. Sachse, C., Brockmöller, J., Bauer, S. & Roots, I. Functional signifcance of a c-A polymorphism in intron 1 of the cytochrome P450 cYP1A2 gene tested with cafeine. Br. J. Clin. Pharmacol. 47, 445-449 (1999).
40. Jiang, Z. et al. Search for an association between the human cYP1A2 genotype and cYP1A2 metabolic phenotype. Pharmacogenet. Genomics 16, 359-367 (2006).
41. Zanger, U.M., Turpeinen, M., Klein, K. & Schwab, M. Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation. Anal. Bioanal. Chem. 392, 1093-1108 (2008).
42. Basvi, P.T., Dandara, C., Bapiro, t. & Hasler, J.A. Role of cYP1A2*1F on cYP1A2 activity in a black African population as determined by cafeine phenotyping. J Chin Clin Med 2, 211-4 (2007).
43. Dandara, C., Basvi, P.T., Bapiro, t.E., Sayi, J. & Hasler, J.A. Frequency of-163 cA and 63 cG single nucleotide polymorphism of cytochrome P450 1A2 in two African populations. Clin. Chem. Lab. Med. 42, 939-941 (2004).
44. Le Marchand, L., Franke, A.A., Custer, L., Wilkens, L.R. & cooney, R.V. Lifestyle and nutritional correlates of cytochrome cYP1A2 activity: inverse associations with plasma lutein and alpha-tocopherol. Pharmacogenetics 7, 11-19 (1997).
45. Smith, P.F., Smith, A., Miners, J.O., McNeil, J. & Proudfoot, A. the Safety Aspects of Dietary cafeine (Australia New Zealand Food Authority, canberra, 2000).
46. Perera, V., Gross, A.S., Xu, H. & McLachlan, A.J. Pharmacokinetics of cafeine in plasma and saliva, and the infuence of cafeine abstinence on cYP1A2 metrics. J. Pharm. Pharmacol. 63, 1161-1168 (2011).
47. Perera, V., Gross, A.S. & McLachlan, A.J. cafeine and paraxanthine HPLc assay for cYP1A2 phenotype assessment using saliva and plasma. Biomed. Chromatogr. 24, 1136-1144 (2010).
48. Gabriel, S., Ziaugra, L. & tabbaa, D. SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr. Protoc. Hum. Genet. chapter 2, Unit 2.12 (2009).
49. Bewick, V., Cheek, L. & Ball, J. Statistics review 10: further nonparametric methods. Crit. Care 8, 196-199 (2004).
50. Sinwell, J.P. & Schaid, D.J. haplo.stats: Statistical Analysis of Haplotypes with traits and covariates when Linkage Phase is Ambiguous. Version 1.5.2 (R, 2011) http://cran.r-project.org/web/packages/haplo.stats/index.html