Modulation of aflatoxin B1-mediated genotoxicity in primary cultures of human hepatocytes by diindolylmethane, curcumin, and xanthohumols

Toxicological Sciences

Volumn 112, Issue 2, 2009, Pages 303-310

  Gross Steinmeyer, Kerstin ^a   Stapleton, Patricia L ^a   Tracy, Julia H ^a   Bammler, Theo K ^a   Strom, Stephen C ^b   Buhler, Donald R ^c   Eaton, David L ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c OREGON STATE UNIVERSITY   (United States)

Author keywords

Biotransformation; CYP; Hepatocytes; Human; Phytochemicals

Indexed keywords

3,3' DIINDOLYLMETHANE; AFLATOXIN B1; CURCUMIN; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; MESSENGER RNA; XANTHOHUMOL; AFLATOXIN B1 DNA ADDUCT; AFLATOXIN B1-DNA ADDUCT; CYTOCHROME P450; DIINDOLYLMETHANE; FLAVONOID; INDOLE DERIVATIVE; MUTAGENIC AGENT; PROPIOPHENONE DERIVATIVE;

ARTICLE; CARCINOGEN DNA INTERACTION; CELL PROTECTION; CONTROLLED STUDY; DNA ADDUCT; DNA DAMAGE; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION REGULATION; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; NUCLEOTIDE SEQUENCE; TRANSCRIPTION INITIATION; CELL CULTURE; GENETICS; METABOLISM; POLYMERASE CHAIN REACTION;

AFLATOXIN B1; CELLS, CULTURED; CURCUMIN; CYTOCHROME P-450 ENZYME SYSTEM; DNA ADDUCTS; FLAVONOIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INDOLES; MUTAGENS; POLYMERASE CHAIN REACTION; PROPIOPHENONES; RNA, MESSENGER;

EID: 74949119638     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp206     Document Type: Article

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