MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry

Applied Immunohistochemistry and Molecular Morphology

Volumn 20, Issue 5, 2012, Pages 470-477

  Okkels, Henrik ^a   Lindorff Larsen, Karen ^a   Thorlasius Ussing, Ole ^a   Vyberg, Mogens ^a   Lindebjerg, Jan ^b   Sunde, Lone ^c   Bernstein, Inge ^d   Klarskov, Louise ^d   Holck, Susanne ^d   Krarup, Henrik Bygum ^a  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b LILLEBAELT HOSPITAL   (Denmark)

^c AARHUS UNIVERSITY HOSPITAL   (Denmark)

^d HVIDOVRE HOSPITAL   (Denmark)

Author keywords

Familial cancer; Hereditary nonpolyposis colorectal cancer; Immunohistochemistry; Lynch syndrome; MSH6

Indexed keywords

GENOMIC DNA; PROTEIN MLH1; PROTEIN MSH2; PROTEIN MSH6;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; COLON ADENOCARCINOMA; DNA PURIFICATION; FAMILIAL CANCER; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC SCREENING; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; HETEROZYGOSITY; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALLELES; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA-BINDING PROTEINS; EXONS; FEMALE; GENE FREQUENCY; HUMANS; IMMUNOHISTOCHEMISTRY; INTRONS; MALE; MUTATION; NEOPLASM PROTEINS; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SENSITIVITY AND SPECIFICITY; SEQUENCE ANALYSIS, DNA;

EID: 84866604260     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e318249739b     Document Type: Article

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