Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding

Journal of Biological Chemistry

Volumn 283, Issue 46, 2008, Pages 31641-31648

  Cyr, Jennifer L ^a   Heinen, Christopher D ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; DNA; HYDROLYSIS; MAINTENANCE; NUCLEIC ACIDS; NUCLEOTIDES; ORGANIC ACIDS;

ATP HYDROLYSES; BIOCHEMICAL ACTIVITIES; CONFORMATION CHANGES; DNA MISMATCH REPAIRS; FUNCTIONAL DOMAINS; HEREDITARY NONPOLYPOSIS COLORECTAL CANCERS; MISMATCH REPAIRS; MISSENSE MUTATIONS; PROCESSING ABILITIES;

GENES;

HETERODIMER; PROTEIN MSH2;

ARTICLE; CHEMICAL ANALYSIS; FAMILIAL CANCER; GENE; GENE DELETION; GENE MUTATION; HMSH6 GENE; HYDROLYSIS; MISSENSE MUTATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DOMAIN;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BASE PAIR MISMATCH; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA-BINDING PROTEINS; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MUTATION, MISSENSE; MUTS HOMOLOG 2 PROTEIN; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

EID: 57649112528     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806018200     Document Type: Article

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