Nitric oxide, can it be only good? Increasing the antioxidant properties of nitric oxide in hepatocytes by YC-1 compound

Nitric Oxide - Biology and Chemistry

Volumn 27, Issue 4, 2012, Pages 248-256

  Aharoni Simon, Michal ^a   Anavi, Sarit ^a   Beifuss, Uwe ^b   Madar, Zecharia ^a   Tirosh, Oren ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

Fat accumulation; Hepatocytes; HIF1 ; Nitric oxide; Nrf 2

Indexed keywords

DIETHYLENETRIAMINE; GLUTATHIONE; GLUTATHIONE TRANSFERASE ALPHA; GUANYLATE CYCLASE; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIFICIGUAT; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME ACTIVITY; GENE EXPRESSION; LIPID METABOLISM; LIPID PEROXIDATION; LIPID STORAGE; LIVER CELL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; GLUTATHIONE; HEME OXYGENASE-1; HEPATOCYTES; HUMANS; INDAZOLES; MICE; NF-E2-RELATED FACTOR 2; NITRIC OXIDE; NITROSO COMPOUNDS; TRANSFORMING GROWTH FACTOR ALPHA;

EID: 84866501455     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2012.08.076     Document Type: Article

References (48)

1. R.M. Rai, F.Y. Lee, and A. Rosen Impaired liver regeneration in inducible nitric oxide synthasedeficient mice Proc. Natl. Acad. Sci. USA 95 1998 13829 13834
2. S. Hortelano, B. Dewez, and A.M. Genaro Nitric oxide is released in regenerating liver after partial hepatectomy Hepatology 21 1995 776 786
3. K.B. Sandau, J. Fandrey, and B. Brune Accumulation of HIF-1alpha under the influence of nitric oxide Blood 97 2001 1009 1015
4. D.A. Geller, A.K. Nussler, and M. Di Silvio Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes Proc. Natl. Acad. Sci. USA 90 1993 522 526
5. J.A. Spitzer Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats Hepatology 19 1994 217 228
6. K.R. Feingold, I. Staprans, and R.A. Memon Endotoxin rapidly induces changes in lipid metabolism that produce hypertriglyceridemia: low doses stimulate hepatic triglyceride production while high doses inhibit clearance J. Lipid Res. 33 1992 1765 1776
7. N. Takeyama, Y. Itoh, Y. Kitazawa, and T. Tanaka Altered hepatic mitochondrial fatty acid oxidation and ketogenesis in endotoxic rats Am. J. Physiol. 259 1990 E498 E505
8. T.A. Stein, G.P. Burns, B.E. Tropp, and L. Wise Hepatic fat accumulation during liver regeneration J. Surg. Res. 39 1985 338 343
9. S. Hortelano, B. Dallaporta, and N. Zamzami Nitric oxide induces apoptosis via triggering mitochondrial permeability transition FEBS Lett. 410 1997 373 377
10. P.K. Kim, R. Zamora, P. Petrosko, and T.R. Billiar The regulatory role of nitric oxide in apoptosis Int. Immunopharmacol. 1 2001 1421 1441
11. Y.M. Kim, R.V. Talanian, and T.R. Billiar Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms J. Biol. Chem. 272 1997 31138 31148
12. J.O. Lundberg, E. Weitzberg, and M.T. Gladwin The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics Nat. Rev. Drug Discovery 7 2008 156 167
13. S. Borniquel, I. Valle, and S. Cadenas Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1alpha FASEB J. 20 2006 1889 1891
14. S. Borniquel, N. Garcia-Quintans, and I. Valle Inactivation of Foxo3a and subsequent downregulation of PGC-1 alpha mediate nitric oxide-induced endothelial cell migration Mol. Cell. Biol. 30 2010 4035 4044
15. C. Szabo, and H. Ohshima DNA damage induced by peroxynitrite: subsequent biological effects Nitric oxide: Biol. Chem. 1 1997 373 385
16. J. Kanner, S. Harel, and R. Granit Nitric oxide, an inhibitor of lipid oxidation by lipoxygenase, cyclooxygenase and hemoglobin Lipids 27 1992 46 49
17. S. Dhakshinamoorthy, and A.G. Porter Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts apoptosis of neuroblastoma cells J. Biol. Chem. 279 2004 20096 20107
18. C.Q. Li, M.Y. Kim, and L.C. Godoy Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells Proc. Natl. Acad. Sci. USA 106 2009 14547 14551
19. S. Fujii, T. Sawa, and H. Ihara The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response J. Biol. Chem. 285 2010 23970 23984
20. T. Gimm, M. Wiese, and B. Teschemacher Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1 FASEB J. 24 2010 4443 4458
21. C. Jiang, A. Qu, and T. Matsubara Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice Diabetes 60 2011 2484 2495
22. H.Y. Kay, W.D. Kim, and S.J. Hwang Nrf2 inhibits LXRalpha-dependent hepatic lipogenesis by competing with FXR for acetylase binding Antioxid. Redox Signaling 15 2011 2135 2146
23. T.A. Beyer, W. Xu, and D. Teupser Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance EMBO J. 27 2008 212 223
24. H.J. Forman, J.M. Fukuto, and M. Torres Redox signaling: thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers Am. J. Physiol. Cell Physiol. 287 2004 C246 C256
25. E. Nisoli, E. Clementi, and C. Paolucci Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide Science 299 2003 896 899
26. J. St-Pierre, S. Drori, and M. Uldry Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators Cell 127 2006 397 408
27. P. Puigserver, and B.M. Spiegelman Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator Endocr. Rev. 24 2003 78 90
28. J.C. Wu, G. Merlino, and N. Fausto Establishment and characterization of differentiated, nontransformed hepatocyte cell lines derived from mice transgenic for transforming growth factor alpha Proc. Natl. Acad. Sci. USA 91 1994 674 678
29. O. Tirosh, A. Artan, and M. Aharoni-Simon Impaired liver glucose production in a murine model of steatosis and endotoxemia: protection by inducible nitric oxide synthase Antioxid. Redox Signaling 13 2010 13 26
30. M. Aharoni-Simon, R. Reifen, and O. Tirosh ROS-production-mediated activation of AP-1 but not NFkappaB inhibits glutamate-induced HT4 neuronal cell death Antioxid. Redox Signaling 8 2006 1339 1349
31. S. Shilo, M. Pardo, and M. Aharoni-Simon Selenium supplementation increases liver MnSOD expression: molecular mechanism for hepato-protection J. Inorg. Biochem. 102 2008 110 118
32. A. Aronis, Z. Madar, and O. Tirosh Lipotoxic effects of triacylglycerols in J774.2 macrophages Nutrition 24 2008 167 176
33. I. Rahman, A. Kode, and S.K. Biswas Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method Nat. Protoc. 1 2006 3159 3165
34. S. Anavi, N.B. Harmelin, Z. Madar, and O. Tirosh Oxidative stress impairs HIF1alpha activation: a novel mechanism for increased vulnerability of steatotic hepatocytes to hypoxic stress Free Radical Biol. Med. 52 2012 1531 1542
35. C.J. Hanke, J.G. Drewett, C.R. Myers, and W.B. Campbell Nitric oxide inhibits aldosterone synthesis by a guanylyl cyclase-independent effect Endocrinology 139 1998 4053 4060
36. E.J. Yeo, Y.S. Chun, and Y.S. Cho YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1 J. Natl. Cancer Inst. 95 2003 516 525
37. E. Nisoli, E. Clementi, M.O. Carruba, and S. Moncada Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ. Res. 100 2007 795 806
38. G.L. Wang, B.H. Jiang, and G.L. Semenza Effect of protein kinase and phosphatase inhibitors on expression of hypoxia-inducible factor 1 Biochem. Biophys. Res. Commun. 216 1995 669 675
39. W.J. Lee, M. Kim, and H.S. Park AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1 Biochem. Biophys. Res. Commun. 340 2006 291 295
40. A. Friebe, and D. Koesling Mechanism of YC-1-induced activation of soluble guanylyl cyclase Mol. Pharmacol. 53 1998 123 127
41. C.N. Hall, and J. Garthwaite What is the real physiological NO concentration in vivo? Nitric oxide: Biol. Chem. 21 2009 92 103
42. L.A. Ridnour, D.D. Thomas, and C. Switzer Molecular mechanisms for discrete nitric oxide levels in cancer Nitric oxide: Biol. Chem. 19 2008 73 76
43. J. He, Y. Xiao, and L. Zhang Cocaine-mediated apoptosis in bovine coronary artery endothelial cells: role of nitric oxide J. Pharmacol. Exp. Ther. 298 2001 180 187
44. B. Fromenty, and D. Pessayre Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity Pharmacol. Ther. 67 1995 101 154
45. Z.Z. Yang, and A.P. Zou Transcriptional regulation of heme oxygenases by HIF-1alpha in renal medullary interstitial cells Am. J. Physiol. Renal Physiol. 281 2001 F900 F908
46. D.S. Bredt Nitric oxide signaling in brain: potentiating the gain with YC-1 Mol. Pharmacol. 63 2003 1206 1208
47. C. Sanchez-Ramos, A. Tierrez, and O. Fabregat-Andres PGC-1alpha regulates translocated in liposarcoma activity: role in oxidative stress gene expression Antioxid. Redox Signaling 15 2011 325 337
48. T. Okumura Role of lipid droplet proteins in liver steatosis J. Physiol. Biochem. 67 2011 629 636