PGC-1α Regulates translocated in liposarcoma activity: Role in oxidative stress gene expression

Antioxidants and Redox Signaling

Volumn 15, Issue 2, 2011, Pages 325-337

  Sánchez Ramos, Cristina ^a   Tierrez, Alberto ^a   Fabregat Andrés, Oscar ^b   Wild, Brigitte ^a   Sánchez Cabo, Fatima ^a   Arduini, Alessandro ^c   Dopazo, Ana ^a   Monsalve, María ^a,d  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE VALENCIA   (Spain)

^c UNIVERSITY OF VALENCIA   (Spain)

^d INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; DETOXIFICATION; DNA DAMAGE; DNA MICROARRAY; GENE EXPRESSION; GENE TRANSLOCATION; LIPOSARCOMA; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSCRIPTION INITIATION;

ANIMALS; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; MICE; OXIDATIVE STRESS; RNA-BINDING PROTEIN FUS; TRANS-ACTIVATORS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 79959532420     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2010.3643     Document Type: Article

References (60)

1. Al Rashid ST, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, Folkard M, Xu Y, Chen BP, Chen DJ, Lilge L, Prise KM, Bazett Jones DP, and Bristow RG. Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo. Cancer Res 65: 10810-10821, 2005. (Pubitemid 41713348)
2. Albers E, Larsson C, Andlid T, Walsh MC, and Gustafsson L. Effect of nutrient starvation on the cellular composition and metabolic capacity of Saccharomyces cerevisiae. Appl Environ Microbiol 73: 4839-4848, 2007. (Pubitemid 47241074)
3. Alliegro MC and Alliegro MA. A nuclear protein regulated during the transition from active to quiescent phenotype in cultured endothelial cells. Dev Biol 174: 288-297, 1996. (Pubitemid 26132686)
4. Antonescu CR, Tschernyavsky SJ, Decuseara R, Leung DH, Woodruff JM, Brennan MF, Bridge JA, Neff JR, Goldblum JR, and Ladanyi M. Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Clin Cancer Res 7: 3977-3987, 2001. (Pubitemid 34044616)
5. Baechtold H, Kuroda M, Sok J, Ron D, Lopez BS, and Akhmedov AT. Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation. J Biol Chem 274: 34337-34342, 1999. (Pubitemid 129511776)
6. Bahjat FR, Dharnidharka VR, Fukuzuka K, Morel L, Crawford JM, Clare-Salzler MJ, and Moldawer LL. Reduced susceptibility of nonobese diabetic mice to TNF-alpha and D-galactosamine-mediated hepatocellular apoptosis and lethality. J Immunol 165: 6559-6567, 2000.
7. Bertolotti A, Bell B, and Tora L. The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties. Oncogene 18: 8000-8010, 1999. (Pubitemid 30050561)
8. Bertrand P, Akhmedov AT, Delacote F, Durrbach A, and Lopez BS. Human POMp75 is identified as the prooncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation. Oncogene 18: 4515-4521, 1999. (Pubitemid 29396659)
9. Borniquel S, Valle I, Cadenas S, Lamas S, and Monsalve M. Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-1alpha. FASEB J 20: 1889-1891, 2006.
10. Bouvet P, Diaz JJ, Kindbeiter K, Madjar JJ, and Amalric F. Nucleolin interacts with several ribosomal proteins through its RGG domain. J Biol Chem 273: 19025-19029, 1998. (Pubitemid 28366294)
11. Burd CG and Dreyfuss G. RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J 13: 1197-1204, 1994. (Pubitemid 24074726)
12. Burhans WC and Heintz NH. The cell cycle is a redox cycle: linking phase-specific targets to cell fate. Free Radic Biol Med 47: 1282-1293, 2009.
13. Cartegni L, Maconi M, Morandi E, Cobianchi F, Riva S, and Biamonti G. hnRNP A1 selectively interacts through its Glyrich domain with different RNA-binding proteins. J Mol Biol 259: 337-348, 1996. (Pubitemid 26179016)
14. Finkel T, Deng CX, and Mostoslavsky R. Recent progress in the biology and physiology of sirtuins. Nature 460: 587-591, 2009.
15. Fu X, Wan S, Lyu YL, Liu LF, and Qi H. Etoposide induces ATM-dependent mitochondrial biogenesis through AMPK activation. PLoS One 3: e2009, 2008.
16. Fujii R and Takumi T. TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines. J Cell Sci 118: 5755-5765, 2005. (Pubitemid 43079269)
17. Gardiner M, Toth R, Vandermoere F, Morrice NA, and Rouse J. Identification and characterization of FUS/TLS as a new target of ATM. Biochem J 415: 297-307, 2008.
18. Ghosh HS. The anti-aging, metabolism potential of SIRT1. Curr Opin Investig Drugs 9: 1095-1102, 2008.
19. Hallier M, Lerga A, Barnache S, Tavitian A, and Moreau-Gachelin F. The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLS. J Biol Chem 273: 4838-4842, 1998. (Pubitemid 28108632)
20. Handschin C. The biology of PGC-1alpha and its therapeutic potential. Trends Pharmacol Sci 30: 322-329, 2009.
21. Hicks GG, Singh N, Nashabi A, Mai S, Bozek G, Klewes L, Arapovic D, White EK, Koury MJ, Oltz EM, Van Kaer L, and Ruley HE. Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat Genet 24: 175-179, 2000. (Pubitemid 30094720)
22. 2 and DMNQ on freshly isolated rat hepatocytes; protective effects of carboxymethyl chitin-glucan. Neuro Endocrinol Lett 29: 644-648, 2008.
23. Hussain SP, Amstad P, He P, Robles A, Lupold S, Kaneko I, Ichimiya M, Sengupta S, Mechanic L, Okamura S, Hofseth LJ, Moake M, Nagashima M, Forrester KS, and Harris CC. p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Res 64: 2350-2356, 2004. (Pubitemid 38523887)
24. Iko Y, Kodama TS, Kasai N, Oyama T, Morita EH, Muto T, Okumura M, Fujii R, Takumi T, Tate S, and Morikawa K. Domain architectures and characterization of an RNA-binding protein, TLS. J Biol Chem 279: 44834-44840, 2004. (Pubitemid 39430895)
25. Jager S, Handschin C, St-Pierre J, and Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A 104: 12017-12022, 2007. (Pubitemid 47185622)
26. Kobayashi Y, Furukawa-Hibi Y, Chen C, Horio Y, Isobe K, Ikeda K, and Motoyama N. SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress. Int J Mol Med 16: 237-243, 2005.
27. Kuroda M, Sok J, Webb L, Baechtold H, Urano F, Yin Y, Chung P, de Rooij DG, Akhmedov A, Ashley T, and Ron D. Male sterility and enhanced radiation sensitivity in TLS(-/-) mice. EMBO J 19: 453-462, 2000. (Pubitemid 30072615)
28. Law WJ, Cann KL, and Hicks GG. TLS, EWS and TAF15: a model for transcriptional integration of gene expression. Brief Funct Genomic Proteomic 5: 8-14, 2006. (Pubitemid 46402988)
29. Lerga A, Hallier M, Delva L, Orvain C, Gallais I, Marie J, and Moreau-Gachelin F. Identification of an RNA binding specificity for the potential splicing factor TLS. J Biol Chem 276: 6807-6816, 2001.
30. Li X, Monks B, Ge Q, and Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature 447: 1012-1016, 2007. (Pubitemid 46975750)
31. Lotem J, Peled-Kamar M, Groner Y, and Sachs L. Cellular oxidative stress and the control of apoptosis by wild-type p53, cytotoxic compounds, and cytokines. Proc Natl Acad Sci U S A 93: 9166-9171, 1996. (Pubitemid 26282036)
32. Meek DW. Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9: 714-723, 2009.
33. Meissner M, Lopato S, Gotzmann J, Sauermann G, and Barta A. Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins. Exp Cell Res 283: 184-195, 2003. (Pubitemid 36269024)
34. Monsalve M, Wu Z, Adelmant G, Puigserver P, Fan M, and Spiegelman BM. Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1. Mol Cell 6: 307-316, 2000.
35. Nemoto S, Fergusson MM, and Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 280: 16456-16460, 2005. (Pubitemid 40616776)
36. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, and Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135: 907-918, 2008.
37. Olmos Y, Valle I, Borniquel S, Tierrez A, Soria E, Lamas S, and Monsalve M. Mutual dependence of Foxo3a and PGC-1alpha in the induction of oxidative stress genes. J Biol Chem 284: 14476-14484, 2009.
38. Panowski SH and Dillin A. Signals of youth: endocrine regulation of aging in Caenorhabditis elegans. Trends Endocrinol Metab 20: 259-264, 2009.
39. Perrotti D, Bonatti S, Trotta R, Martinez R, Skorski T, Salomoni P, Grassilli E, Lozzo RV, Cooper DR, and Calabretta B. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO J 17: 4442-4455, 1998. (Pubitemid 28362633)
40. Pessayre D, Mansouri A, Berson A, and Fromenty B. Mitochondrial involvement in drug-induced liver injury. Handb Exp Pharmacol: 311-365, 2010.
41. Powers CA, Mathur M, Raaka BM, Ron D, and Samuels HH. TLS (translocated-in-liposarcoma) is a high-affinity inter-actor for steroid, thyroid hormone, and retinoid receptors. Mol Endocrinol 12: 4-18, 1998. (Pubitemid 28124775)
42. Prozorovski T, Schulze-Topphoff U, Glumm R, Baumgart J, Schroter F, Ninnemann O, Siegert E, Bendix I, Brustle O, Nitsch R, Zipp F, and Aktas O. Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol 10: 385-394, 2008.
43. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, and Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423: 550-555, 2003. (Pubitemid 36648580)
44. Rana B, Mischoulon D, Xie Y, Bucher NL, and Farmer SR. Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Mol Cell Biol 14: 5858-5869, 1994.
45. Sahin E and Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 464: 520-528, 2010.
46. Saleem A, Adhihetty PJ, and Hood DA. Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiol Genomics 37: 58-66, 2009.
47. Seyfried TN and Shelton LM. Cancer as a metabolic disease. Nutr Metab (Lond) 7: 7, 2010.
48. Shin DJ, Campos JA, Gil G, and Osborne TF. PGC-1alpha activates CYP7A1 and bile acid biosynthesis. J Biol Chem 278: 50047-50052, 2003. (Pubitemid 37548841)
49. Simbula G, Columbano A, Ledda-Columbano GM, Sanna L, Deidda M, Diana A, and Pibiri M. Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells. Apoptosis 12: 113-123, 2007. (Pubitemid 46009508)
50. Speckmann B, Walter PL, Alili L, Reinehr R, Sies H, Klotz LO, and Steinbrenner H. Selenoprotein P expression is controlled through interaction of the coactivator PGC-1alpha with FoxO1a and hepatocyte nuclear factor 4alpha transcription factors. Hepatology 48: 1998-2006, 2008.
51. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, and Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127: 397-408, 2006. (Pubitemid 44572377)
52. Tan AY and Manley JL. The TET family of proteins: functions and roles in disease. J Mol Cell Biol 1: 82-92, 2009.
53. Uranishi H, Tetsuka T, Yamashita M, Asamitsu K, Shimizu M, Itoh M, and Okamoto T. Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator. J Biol Chem 276: 13395-13401, 2001.
54. Valle I, Alvarez-Barrientos A, Arza E, Lamas S, and Monsalve M. PGC-1alpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells. Cardiovasc Res 66: 562-573, 2005. (Pubitemid 40725768)
55. Vousden KH and Ryan KM. p53 and metabolism. Nat Rev Cancer 9: 691-700, 2009.
56. Wang X, Arai S, Song X, Reichart D, Du K, Pascual G, Tempst P, Rosenfeld MG, Glass CK, and Kurokawa R. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 454: 126-130, 2008. (Pubitemid 351934270)
57. Wu D and Cederbaum AI. Oxidative stress and alcoholic liver disease. Semin Liver Dis 29: 141-154, 2009.
58. Yang L, Embree LJ, Tsai S, and Hickstein DD. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem 273: 27761-27764, 1998. (Pubitemid 28496059)
59. Zinszner H, Albalat R, and Ron D. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP. Genes Dev 8: 2513-2526, 1994. (Pubitemid 24347243)
60. Zuin A, Carmona M, Morales-Ivorra I, Gabrielli N, Vivancos AP, Ayte J, and Hidalgo E. Lifespan extension by calorie restriction relies on the Sty1 MAP kinase stress pathway. EMBO J 29: 981-991.