A Conserved Motif in the ITK PH-Domain Is Required for Phosphoinositide Binding and TCR Signaling but Dispensable for Adaptor Protein Interactions

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Hirve, Nupura ^a   Levytskyy, Roman M ^a   Rigaud, Stephanie ^b   Guimond, David M ^a   Zal, Tomasz ^c   Sauer, Karsten ^b   Tsoukas, Constantine D ^a  

^a SAN DIEGO STATE UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; INTERLEUKIN 4; LAT PROTEIN; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOLIPASE C GAMMA1; SLP 76 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELLULAR DISTRIBUTION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; INDUCIBLE T CELL KINASE PLECKSTRIN HOMOLOGY DOMAIN; MALE; MOUSE; MUTATION; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL NUCLEUS; CONSERVED SEQUENCE; HEK293 CELLS; HUMANS; INTERLEUKIN-4; JURKAT CELLS; MICE; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; TRANSFECTION;

EID: 84866494001     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045158     Document Type: Article

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