A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Serrao, Erik ^a   Thys, Wannes ^b   Demeulemeester, Jonas ^b   Al Mawsawi, Laith Q ^a   Christ, Frauke ^b   Debyser, Zeger ^b   Neamati, Nouri ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b DEPARTMENT OF PHARMACEUTICAL AND PHARMACOLOGICAL SCIENCES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE;

AMINO ACID SUBSTITUTION; ARTICLE; DIMERIZATION; ENZYME ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; LUMINESCENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGOMERIZATION; QUANTITATIVE ANALYSIS; SITE DIRECTED MUTAGENESIS; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ESCHERICHIA COLI; HIV INTEGRASE; HIV-1; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84866485829     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045177     Document Type: Article

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