Sequence-based design and discovery of peptide inhibitors of HIV-1 integrase: Insight into the binding mode of the enzyme

Journal of Medicinal Chemistry

Volumn 49, Issue 15, 2006, Pages 4477-4486

  Li, Hui Yuan ^a   Zawahir, Zahrah ^b   Song, Lai Dong ^a   Long, Ya Qiu ^a   Neamati, Nouri ^b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; AMINO ACID; CARBONYL DERIVATIVE; FLUORENYLMETHOXYCARBONYL DERIVATIVE; FLUORENYLMETHOXYCARBONYLALANYLCYSTEINYLTRYPTOPHYLTRYPTOPHYLALANYLGLYCYLISOL EUCYLLYSYLGLUTAMINYLGLUTAMYLPHENYLALANINAMIDE; FLUORENYLMETHOXYCARBONYLTHREONYLALANYLTYROSYLPHENYLALANYLLEUCYLLEUCYLLYSYLL EUCYLALANYLGLYCYLARGINYLTRYPTOPHANAMIDE; INTEGRASE; INTEGRASE INHIBITOR; PEPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHIRALITY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; EVALUATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; LIFE CYCLE; NONHUMAN; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SOLID PHASE SYNTHESIS; VIRUS CELL INTERACTION; VIRUS REPLICATION;

AMINO ACID SEQUENCE; CATALYSIS; CIRCULAR DICHROISM; CONSERVED SEQUENCE; DNA, VIRAL; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN CONFORMATION; VIRUS REPLICATION;

EID: 33746753302     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060307u     Document Type: Article

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