-
1
-
-
46749145822
-
Mechanisms of aging and energy metabolism in Caenorhabditis elegans
-
Artal-Sanz M., Tavernarakis N. (2008) Mechanisms of aging and energy metabolism in Caenorhabditis elegans. IUBMB Life 60, 315-322.
-
(2008)
IUBMB Life
, vol.60
, pp. 315-322
-
-
Artal-Sanz, M.1
Tavernarakis, N.2
-
2
-
-
79951740192
-
Identification of novel FUS mutations in sporadic cases of amyotrophic lateral sclerosis
-
Belzil V. V., Daoud H., St-Onge J., Desjarlais A., Bouchard J. P., Dupre N., Lacomblez L., Salachas F., Pradat P. F., Meininger V., Camu W., Dion P. A., Rouleau G. A. (2011) Identification of novel FUS mutations in sporadic cases of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. 12, 113-117.
-
(2011)
Amyotroph. Lateral Scler.
, vol.12
, pp. 113-117
-
-
Belzil, V.V.1
Daoud, H.2
St-Onge, J.3
Desjarlais, A.4
Bouchard, J.P.5
Dupre, N.6
Lacomblez, L.7
Salachas, F.8
Pradat, P.F.9
Meininger, V.10
Camu, W.11
Dion, P.A.12
Rouleau, G.A.13
-
3
-
-
0037011917
-
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
-
Calfon M., Zeng H., Urano F., Till J. H., Hubbard S. R., Harding H. P., Clark S. G., Ron D. (2002) IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature, 415, 92-96.
-
(2002)
Nature
, vol.415
, pp. 92-96
-
-
Calfon, M.1
Zeng, H.2
Urano, F.3
Till, J.H.4
Hubbard, S.R.5
Harding, H.P.6
Clark, S.G.7
Ron, D.8
-
4
-
-
67651004289
-
A conserved ubiquitination pathway determines longevity in response to diet restriction
-
Carrano A. C., Liu Z., Dillin A., Hunter T. (2009) A conserved ubiquitination pathway determines longevity in response to diet restriction. Nature 460, 396-399.
-
(2009)
Nature
, vol.460
, pp. 396-399
-
-
Carrano, A.C.1
Liu, Z.2
Dillin, A.3
Hunter, T.4
-
5
-
-
57349200362
-
Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response
-
Choe K. P., Strange K. (2008) Genome-wide RNAi screen and in vivo protein aggregation reporters identify degradation of damaged proteins as an essential hypertonic stress response. Am. J. Physiol. Cell Physiol. 295, C1488-C1498.
-
(2008)
Am. J. Physiol. Cell Physiol.
, vol.295
-
-
Choe, K.P.1
Strange, K.2
-
6
-
-
33748792821
-
Opposing activities protect against age-onset proteotoxicity
-
Cohen E., Bieschke J., Perciavalle R. M., Kelly J. W., Dillin A. (2006) Opposing activities protect against age-onset proteotoxicity. Science 313, 1604-1610.
-
(2006)
Science
, vol.313
, pp. 1604-1610
-
-
Cohen, E.1
Bieschke, J.2
Perciavalle, R.M.3
Kelly, J.W.4
Dillin, A.5
-
7
-
-
77956795163
-
Widespread protein aggregation as an inherent part of aging in C. elegans
-
David D. C., Ollikainen N., Trinidad J. C., Cary M. P., Burlingame A. L., Kenyon C. (2010) Widespread protein aggregation as an inherent part of aging in C. elegans. PLoS Biol. 8, e1000450.
-
(2010)
PLoS Biol.
, vol.8
-
-
David, D.C.1
Ollikainen, N.2
Trinidad, J.C.3
Cary, M.P.4
Burlingame, A.L.5
Kenyon, C.6
-
8
-
-
33746278194
-
The selfish brain: competition for energy resources
-
Fehm H. L., Kern W., Peters A. (2006) The selfish brain: competition for energy resources. Prog. Brain Res. 153, 129-140.
-
(2006)
Prog. Brain Res.
, vol.153
, pp. 129-140
-
-
Fehm, H.L.1
Kern, W.2
Peters, A.3
-
9
-
-
77952647809
-
skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans
-
Ferguson A. A., Springer M. G., Fisher A. L. (2010) skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans. Mol. Cell. Biol. 30, 2651-2667.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 2651-2667
-
-
Ferguson, A.A.1
Springer, M.G.2
Fisher, A.L.3
-
10
-
-
78349297565
-
Oxidative stress and diabetic complications
-
Giacco F., Brownlee M. (2010) Oxidative stress and diabetic complications. Circ. Res. 107, 1058-1070.
-
(2010)
Circ. Res.
, vol.107
, pp. 1058-1070
-
-
Giacco, F.1
Brownlee, M.2
-
11
-
-
33644850056
-
Progressive disruption of cellular protein folding in models of polyglutamine diseases
-
Gidalevitz T., Ben-Zvi A., Ho K. H., Brignull H. R., Morimoto R. I. (2006) Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311, 1471-1474.
-
(2006)
Science
, vol.311
, pp. 1471-1474
-
-
Gidalevitz, T.1
Ben-Zvi, A.2
Ho, K.H.3
Brignull, H.R.4
Morimoto, R.I.5
-
12
-
-
0038701745
-
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
-
Hsu A. L., Murphy C. T., Kenyon C. (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145.
-
(2003)
Science
, vol.300
, pp. 1142-1145
-
-
Hsu, A.L.1
Murphy, C.T.2
Kenyon, C.3
-
13
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
Kabashi E., Valdmanis P. N., Dion P., Spiegelman D., McConkey B. J., Velde C. V., Bouchard J. P., Lacomblez L., Pochigaeva K., Salachas F. et al. (2008) TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat. Genet. 40, 572-574.
-
(2008)
Nat. Genet.
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Velde, C.V.6
Bouchard, J.P.7
Lacomblez, L.8
Pochigaeva, K.9
Salachas, F.10
-
14
-
-
33751250243
-
Lifespan extension in Caenorhabditis elegans by complete removal of food
-
Kaeberlein T. L., Smith E. D., Tsuchiya M., Welton K. L., Thomas J. H., Fields S., Kennedy B. K., Kaeberlein M. (2006) Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5, 487-494.
-
(2006)
Aging Cell
, vol.5
, pp. 487-494
-
-
Kaeberlein, T.L.1
Smith, E.D.2
Tsuchiya, M.3
Welton, K.L.4
Thomas, J.H.5
Fields, S.6
Kennedy, B.K.7
Kaeberlein, M.8
-
15
-
-
13944269223
-
The plasticity of aging: insights from long-lived mutants
-
Kenyon C. (2005) The plasticity of aging: insights from long-lived mutants. Cell 120, 449-460.
-
(2005)
Cell
, vol.120
, pp. 449-460
-
-
Kenyon, C.1
-
16
-
-
77950200010
-
The genetics of ageing
-
Kenyon C. J. (2010) The genetics of ageing. Nature 464, 504-512.
-
(2010)
Nature
, vol.464
, pp. 504-512
-
-
Kenyon, C.J.1
-
17
-
-
77649128585
-
HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C. elegans
-
Kern A., Ackermann B., Clement A. M., Duerk H., Behl C. (2010) HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C. elegans. PLoS ONE 5, e8568.
-
(2010)
PLoS ONE
, vol.5
-
-
Kern, A.1
Ackermann, B.2
Clement, A.M.3
Duerk, H.4
Behl, C.5
-
18
-
-
80052641987
-
Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
-
Kerr F., Augustin H., Piper M. D., Gandy C., Allen M. J., Lovestone S., Partridge L. (2011) Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease. Neurobiol. Aging 32, 1977-1989.
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 1977-1989
-
-
Kerr, F.1
Augustin, H.2
Piper, M.D.3
Gandy, C.4
Allen, M.J.5
Lovestone, S.6
Partridge, L.7
-
19
-
-
0032573178
-
The genetics of caloric restriction in Caenorhabditis elegans
-
Lakowski B., Hekimi S. (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl Acad. Sci. U.S.A. 95, 13091-13096.
-
(1998)
Proc. Natl Acad. Sci. U.S.A.
, vol.95
, pp. 13091-13096
-
-
Lakowski, B.1
Hekimi, S.2
-
20
-
-
42249107018
-
Glucose homeostasis in Huntington disease: abnormalities in insulin sensitivity and early-phase insulin secretion
-
Lalic N. M., Maric J., Svetel M., Jotic A., Stefanova E., Lalic K., Dragasevic N., Milicic T., Lukic L., Kostic V. S. (2008) Glucose homeostasis in Huntington disease: abnormalities in insulin sensitivity and early-phase insulin secretion. Arch. Neurol. 65, 476-480.
-
(2008)
Arch. Neurol.
, vol.65
, pp. 476-480
-
-
Lalic, N.M.1
Maric, J.2
Svetel, M.3
Jotic, A.4
Stefanova, E.5
Lalic, K.6
Dragasevic, N.7
Milicic, T.8
Lukic, L.9
Kostic, V.S.10
-
22
-
-
70350365110
-
Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression
-
Lee S. J., Murphy C. T., Kenyon C. (2009) Glucose shortens the life span of C. elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression. Cell Metab. 10, 379-391.
-
(2009)
Cell Metab.
, vol.10
, pp. 379-391
-
-
Lee, S.J.1
Murphy, C.T.2
Kenyon, C.3
-
23
-
-
79958195216
-
O-GlcNAc Cycling and Insulin Signaling are Required for the Glucose Stress Response in Caenorhabditis elegans
-
Mondoux M. A., Love D. C., Ghosh S. K., Fukushige T., Bond M., Weerasinghe G. R., Hanover J. A., Krause M. W. (2011) O-GlcNAc Cycling and Insulin Signaling are Required for the Glucose Stress Response in Caenorhabditis elegans. Genetics 188, 369-382.
-
(2011)
Genetics
, vol.188
, pp. 369-382
-
-
Mondoux, M.A.1
Love, D.C.2
Ghosh, S.K.3
Fukushige, T.4
Bond, M.5
Weerasinghe, G.R.6
Hanover, J.A.7
Krause, M.W.8
-
24
-
-
44849094781
-
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
-
Morimoto R. I. (2008) Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev. 22, 1427-1438.
-
(2008)
Genes Dev.
, vol.22
, pp. 1427-1438
-
-
Morimoto, R.I.1
-
25
-
-
0036678146
-
The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans
-
Morley J. F., Brignull H. R., Weyers J. J., Morimoto R. I. (2002) The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proc. Natl Acad. Sci. U.S.A. 99, 10417-10422.
-
(2002)
Proc. Natl Acad. Sci. U.S.A.
, vol.99
, pp. 10417-10422
-
-
Morley, J.F.1
Brignull, H.R.2
Weyers, J.J.3
Morimoto, R.I.4
-
26
-
-
0035818590
-
Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death
-
Parker J. A., Connolly J. B., Wellington C., Hayden M., Dausset J., Neri C. (2001) Expanded polyglutamines in Caenorhabditis elegans cause axonal abnormalities and severe dysfunction of PLM mechanosensory neurons without cell death. Proc. Natl Acad. Sci. U.S.A. 98, 13318-13323.
-
(2001)
Proc. Natl Acad. Sci. U.S.A.
, vol.98
, pp. 13318-13323
-
-
Parker, J.A.1
Connolly, J.B.2
Wellington, C.3
Hayden, M.4
Dausset, J.5
Neri, C.6
-
27
-
-
16844375290
-
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
-
Parker J. A., Arango M., Abderrahmane S., Lambert E., Tourette C., Catoire H., Neri C. (2005) Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons. Nat. Genet. 37, 349-350.
-
(2005)
Nat. Genet.
, vol.37
, pp. 349-350
-
-
Parker, J.A.1
Arango, M.2
Abderrahmane, S.3
Lambert, E.4
Tourette, C.5
Catoire, H.6
Neri, C.7
-
28
-
-
35348913211
-
Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity
-
Parker J. A., Metzler M., Georgiou J., Mage M., Roder J. C., Rose A. M., Hayden M. R., Neri C. (2007) Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity. J. Neurosci. 27, 11056-11064.
-
(2007)
J. Neurosci.
, vol.27
, pp. 11056-11064
-
-
Parker, J.A.1
Metzler, M.2
Georgiou, J.3
Mage, M.4
Roder, J.C.5
Rose, A.M.6
Hayden, M.R.7
Neri, C.8
-
29
-
-
77949752957
-
Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS
-
Patel B. P., Safdar A., Raha S., Tarnopolsky M. A., Hamadeh M. J. (2010) Caloric restriction shortens lifespan through an increase in lipid peroxidation, inflammation and apoptosis in the G93A mouse, an animal model of ALS. PLoS ONE 5, e9386.
-
(2010)
PLoS ONE
, vol.5
-
-
Patel, B.P.1
Safdar, A.2
Raha, S.3
Tarnopolsky, M.A.4
Hamadeh, M.J.5
-
30
-
-
0017369458
-
Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease
-
Podolsky S., Leopold N. A. (1977) Abnormal glucose tolerance and arginine tolerance tests in Huntington's disease. Gerontology 23, 55-63.
-
(1977)
Gerontology
, vol.23
, pp. 55-63
-
-
Podolsky, S.1
Leopold, N.A.2
-
31
-
-
77649312506
-
Impaired glucose tolerance in patients with amyotrophic lateral sclerosis
-
Pradat P. F., Bruneteau G., Gordon P. H., Dupuis L., Bonnefont-Rousselot D., Simon D., Salachas F., Corcia P., Frochot V., Lacorte J. M. et al. (2010) Impaired glucose tolerance in patients with amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. 11, 166-171.
-
(2010)
Amyotroph. Lateral Scler.
, vol.11
, pp. 166-171
-
-
Pradat, P.F.1
Bruneteau, G.2
Gordon, P.H.3
Dupuis, L.4
Bonnefont-Rousselot, D.5
Simon, D.6
Salachas, F.7
Corcia, P.8
Frochot, V.9
Lacorte, J.M.10
-
32
-
-
34748850786
-
Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
-
Schulz T. J., Zarse K., Voigt A., Urban N., Birringer M., Ristow M. (2007) Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metab. 6, 280-293.
-
(2007)
Cell Metab.
, vol.6
, pp. 280-293
-
-
Schulz, T.J.1
Zarse, K.2
Voigt, A.3
Urban, N.4
Birringer, M.5
Ristow, M.6
-
33
-
-
44649170501
-
Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans
-
Smith E. D., Kaeberlein T. L., Lydum B. T., Sager J., Welton K. L., Kennedy B. K., Kaeberlein M. (2008) Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev. Biol. 8, 49.
-
(2008)
BMC Dev. Biol.
, vol.8
, pp. 49
-
-
Smith, E.D.1
Kaeberlein, T.L.2
Lydum, B.T.3
Sager, J.4
Welton, K.L.5
Kennedy, B.K.6
Kaeberlein, M.7
-
34
-
-
43449138491
-
Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans
-
Steinkraus K. A., Smith E. D., Davis C., Carr D., Pendergrass W. R., Sutphin G. L., Kennedy B. K., Kaeberlein M. (2008) Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans. Aging Cell 7, 394-404.
-
(2008)
Aging Cell
, vol.7
, pp. 394-404
-
-
Steinkraus, K.A.1
Smith, E.D.2
Davis, C.3
Carr, D.4
Pendergrass, W.R.5
Sutphin, G.L.6
Kennedy, B.K.7
Kaeberlein, M.8
-
35
-
-
84857410364
-
Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans
-
Vaccaro A., Tauffenberger A., Aggad D., Rouleau G., Drapeau P., Parker J. A. (2012) Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans. PLoS ONE 7, e31321.
-
(2012)
PLoS ONE
, vol.7
-
-
Vaccaro, A.1
Tauffenberger, A.2
Aggad, D.3
Rouleau, G.4
Drapeau, P.5
Parker, J.A.6
-
36
-
-
61449184625
-
Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans
-
Van Raamsdonk J. M., Hekimi S. (2009) Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet. 5, e1000361.
-
(2009)
PLoS Genet.
, vol.5
-
-
Van Raamsdonk, J.M.1
Hekimi, S.2
-
37
-
-
36148982248
-
Glycemic index and glycemic load: measurement issues and their effect on diet-disease relationships
-
Venn B. J., Green T. J. (2007) Glycemic index and glycemic load: measurement issues and their effect on diet-disease relationships. Eur. J. Clin. Nutr. 61(Suppl 1), S122-S131.
-
(2007)
Eur. J. Clin. Nutr.
, vol.61
, Issue.SUPPL. 1
-
-
Venn, B.J.1
Green, T.J.2
-
38
-
-
4944234936
-
Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones
-
Yoneda T., Benedetti C., Urano F., Clark S. G., Harding H. P., Ron D. (2004) Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J. Cell Sci. 117, 4055-4066.
-
(2004)
J. Cell Sci.
, vol.117
, pp. 4055-4066
-
-
Yoneda, T.1
Benedetti, C.2
Urano, F.3
Clark, S.G.4
Harding, H.P.5
Ron, D.6
-
39
-
-
79955433159
-
TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling
-
Zhang T., Mullane P. C., Periz G., Wang J. (2011) TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling. Hum. Mol. Genet. 20, 1952-1965.
-
(2011)
Hum. Mol. Genet.
, vol.20
, pp. 1952-1965
-
-
Zhang, T.1
Mullane, P.C.2
Periz, G.3
Wang, J.4
|