Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities

Molecular Medicine Reports

Volumn 6, Issue 5, 2012, Pages 1126-1132

  Yang, Li Heng ^a,b   Ho, Ying Jui ^c   Lin, Jing Feng ^c   Yeh, Chi Wei ^c   Kao, Shao Hsuan ^c   Hsu, Li Sung ^c,d  

^a CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

^b Nantou Christian Hospital   (Taiwan)

^c CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^d CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Breast cancer; Butein; Extracellular signal regulated kinase; p38; Reactive oxygen species

Indexed keywords

ACETYLCYSTEINE; BUTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; POLY(ADENOSINE DIPHOSPHATE RIBOSE); REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INHIBITION; CELL DEATH; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MODULATION; PROTEIN EXPRESSION;

ACETYLCYSTEINE; ANTIOXIDANTS; BREAST NEOPLASMS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CHALCONES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 84866451206     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1023     Document Type: Article

References (43)

1. Kelloff GJ, Boone CW, Crowell JA, Steele VE, Lubet R and Sigman CC: Chemopreventive drug development: perspectives and progress. Cancer Epidemiol Biomarkers Prev 3: 85-98, 1994. (Pubitemid 24172528)
2. Khan N, Afaq F and Mukhtar H: Cancer chemoprevention through dietary antioxidants: progress and promise. Antioxid Redox Signal 10: 475-510, 2008.
3. Lee JC, Lee KY, Kim J, Na CS, et al: Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. Food Chem Toxicol 42: 1383-1388, 2004. (Pubitemid 38844855)
4. Jung CH, Jun CY, Lee S, Park CH, Cho K and Ko SG: Rhus verniciflua stokes extract: radical scavenging activities and protective effects on H2O2-induced cytotoxicity in macrophage RAW 264.7 cell lines. Biol Pharm Bull 29: 1603-1607, 2006. (Pubitemid 44166359)
5. Jung CH, Kim JH, Hong MH, et al: Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 110: 490-497, 2007. (Pubitemid 46386364)
6. Aizu E, Nakadate T, Yamamoto S and Kato R: Inhibition of 12-O-tetradecanoylphorbol-13-acetate-mediated epidermal ornithine decarboxylase induction and skin tumor promotion by new lipoxygenase inhibitors lacking protein kinase C inhibitory effects. Carcinogenesis 7: 1809-1812, 1986.
7. Kang DG, Lee AS, Mun YJ, et al: Butein ameliorates renal concentrating ability in cisplatin-induced acute renal failure in rats. Biol Pharm Bull 27: 366-370, 2004. (Pubitemid 41685481)
8. Lim SS, Jung SH, Ji J, Shin KH and Keum SR: Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. J Pharm Pharmacol 53: 653-668, 2001. (Pubitemid 32457816)
9. Lee SH, Nan JX, Zhao YZ, et al: The chalcone butein from Rhus verniciflua shows antifibrogenic activity. Planta Med 69: 990-994, 2003. (Pubitemid 38064686)
10. Jang HS, Kook SH, Son YO, et al: Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. Biochim Biophys Acta 1726: 309-316, 2005.
11. Kook SH, Son YO, Chung SW, et al: Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G. Apoptosis 12: 1289-1298, 2007.
12. Ramanathan R, Tan CH and Das NP: Cytotoxic effect of plant polyphenols and fat-soluble vitamins on malignant human cultured cells. Cancer Lett 62: 217-224, 1992.
13. Yit CC and Das NP: Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation. Cancer Lett 82: 65-72, 1994. (Pubitemid 24211073)
14. Iwashita K, Kobori M, Yamaki K and Tsushida T: Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells. Biosci Biotechnol Biochem 64: 1813-1820, 2000.
15. Pandey MK, Sung B, Ahn KS and Aggarwal BB: Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Mol Pharmacol 75: 525-533, 2009.
16. Rajendran P, Ong TH, Chen L, et al: Suppression of signal transducer and activator of transcription 3 activation by butein inhibits growth of human hepatocellular carcinoma in vivo. Clin Cancer Res 17: 1425-1439, 2011.
17. Moon DO, Choi YH, Moon SK, Kim WJ and Kim GY: Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells. Toxicol In Vitro 24: 1927-1934, 2010.
18. Yang CS, Yang GY, Landau JM, Kim S and Liao J: Tea and tea polyphenols inhibit cell hyperproliferation, lung tumorigenesis, and tumor progression. Exp Lung Res 24: 629-639, 1998. (Pubitemid 28308956)
19. Kim JH, Jung CH, Jang BH, et al: Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes. Am J Chin Med 37: 609-620, 2009.
20. Chua AW, Hay HS, Rajendran P, et al: Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-kappaB activation in breast and pancreatic tumor cells. Biochem Pharmacol 80: 1553-1562, 2010.
21. Lau GT, Huang H, Lin SM and Leung LK: Butein downregulates phorbol 12-myristate 13-acetate-induced COX-2 transcriptional activity in cancerous and non-cancerous breast cells. Eur J Pharmacol 648: 24-30, 2010.
22. Zhang W and Liu HT: MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res 12: 9-18, 2002.
23. Shankar S, Ganapathy S and Srivastava RK: Green tea polyphenols: biology and therapeutic implications in cancer. Front Biosci 12: 4881-4899, 2007.
24. Stoner GD and Mukhtar H: Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl 22: 169-180, 1995.
25. Raman M, Chen W and Cobb MH: Differential regulation and properties of MAPKs. Oncogene 26: 3100-3112, 2007. (Pubitemid 46763006)
26. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M and Lord JM: Serine/threonine protein kinases and apoptosis. Exp Cell Res 256: 34-41, 2000. (Pubitemid 30211164)
27. Chang IC, Huang YJ, Chiang TI, Yeh CW and Hsu LS: Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells. Biol Pharm Bull 33: 816-824, 2010.
28. Fresco P, Borges F, Diniz C and Marques MP: New insights on the anticancer properties of dietary polyphenols. Med Res Rev 26: 747-766, 2006. (Pubitemid 44735552)
29. Sarkar FH, Li Y, Wang Z and Kong D: Cellular signaling perturbation by natural products. Cell Signal 21: 1541-1547, 2009.
30. Shankar S, Suthakar G and Srivastava RK: Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. Front Biosci 12: 5039-5051, 2007.
31. Granado-Serrano AB, Martin MA, Bravo L, Goya L and Ramos S: Quercetin induces apoptosis via caspase activation, regulation of Bcl-2, and inhibition of PI-3-kinase/Akt and ERK pathways in a human hepatoma cell line (HepG2). J Nutr 136: 2715-2721, 2006. (Pubitemid 44771763)
32. Kim EJ, Choi CH, Park JY, Kang SK and Kim YK: Underlying mechanism of quercetin-induced cell death in human glioma cells. Neurochem Res 33: 971-979, 2008.
33. Zhang L, Chen W and Li X: A novel anticancer effect of butein: inhibition of invasion through the ERK1/2 and NF-kappa B signaling pathways in bladder cancer cells. FEBS Lett 582: 1821-1828, 2008.
34. Lee SH, Seo GS, Jin XY, Ko G and Sohn DH: Butein blocks tumor necrosis factor alpha-induced interleukin 8 and matrix metalloproteinase 7 production by inhibiting p38 kinase and osteopontin mediated signaling events in HT-29 cells. Life Sci 81: 1535-1543, 2007. (Pubitemid 350060926)
35. Cory S and Adams JM: The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2: 647-656, 2002. (Pubitemid 37328916)
36. Kim NY, Pae HO, Oh GS, et al: Butein, a plant polyphenol, induces apoptosis concomitant with increased caspase-3 activity, decreased Bcl-2 expression and increased Bax expression in HL-60 cells. Pharmacol Toxicol 88: 261-266, 2001.
37. Bechtel W and Bauer G: Modulation of intercellular ROS signaling of human tumor cells. Anticancer Res 29: 4559-4570, 2009.
38. Victor VM, Rocha M, Sola E, Banuls C, Garcia-Malpartida K and Hernandez-Mijares A: Oxidative stress, endothelial dysfunction and atherosclerosis. Curr Pharm Des 15: 2988-3002, 2009.
39. Shukla S and Gupta S: Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free Radic Biol Med 44: 1833-1845, 2008.
40. Nakazato T, Ito K, Ikeda Y and Kizaki M: Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species. Clin Cancer Res 11: 6040-6049, 2005. (Pubitemid 41170336)
41. Sharma V, Joseph C, Ghosh S, Agarwal A, Mishra MK and Sen E: Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol Cancer Ther 6: 2544-2553, 2007. (Pubitemid 47480420)
42. Moon DO, Kim MO, Choi YH, Hyun JW, Chang WY and Kim GY: Butein induces G(2)/M phase arrest and apoptosis in human hepatoma cancer cells through ROS generation. Cancer Lett 288: 204-213, 2010.
43. Chen YH, Yeh CW, Lo HC, Su SL, Hseu YC and Hsu LS: Generation of reactive oxygen species mediates butein-induced apoptosis in neuroblastoma cells. Oncol Rep 27: 1233-1237, 2012.