Caspase-independent death of human osteosarcoma cells by flavonoids is driven by p53-mediated mitochondrial stress and nuclear translocation of AIF and endonuclease G

Apoptosis

Volumn 12, Issue 7, 2007, Pages 1289-1298

  Kook, Sung Ho ^a   Son, Young Ok ^a   Chung, Song Woo ^a   Lee, Seung Ah ^a,b   Kim, Jong Ghee ^a   Jeon, Young Mi ^a   Lee, Jeong Chae ^a  

^a Chonbuk National University   (South Korea)

^b Chonnam Techno College   (South Korea)

Author keywords

Apoptosis; Flavonoid; HOS cells; Mitochondrial apoptogenic factor; p53

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; CYTOCHROME C; ENDONUCLEASE G; FLAVONOID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CELL STRESS; CONTROLLED STUDY; CYTOPLASM; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; HUMAN; HUMAN CELL; MITOCHONDRION; OSTEOSARCOMA; POISON IVY; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; RHUS VERNICIFLUA;

APOPTOSIS; APOPTOSIS INDUCING FACTOR; CASPASES; CELL LINE, TUMOR; ENDODEOXYRIBONUCLEASES; FLAVONOIDS; HUMANS; KOREA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; OSTEOSARCOMA; RHUS; TUMOR SUPPRESSOR PROTEIN P53;

TOXICODENDRON VERNICIFLUUM;

EID: 34249987420     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0056-x     Document Type: Article

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