A novel PKB/Akt inhibitor, MK-2206,effectivelyinhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle

Biochemical Journal

Volumn 447, Issue 1, 2012, Pages 137-147

  Lai, Yu Chiang ^a   Liu, Yang ^a   Jacobs, Roxane ^a   Rider, Mark H ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Akt substrate of 160 kDa (AS160); Akti; Glucose uptake; Glycogen synthase kinase 3 (GSK3); Mammalian target of rapamycin (mTOR); Proline rich Akt substrate of 40 kDa (PRAS40)

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; AKTI 1/2; ELONGATION FACTOR 2; GLYCOGEN; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; PROLINE RICH PROTEIN; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN KINASE B INHIBITOR; PROTEIN P70; S6 KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; IC 50; MALE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SOLEUS MUSCLE;

ANDROSTADIENES; ANIMALS; CELL LINE; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; GTPASE-ACTIVATING PROTEINS; HETEROCYCLIC COMPOUNDS, 3-RING; INSULIN; MALE; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION;

EUKARYOTA; MAMMALIA; RATTUS;

EID: 84866425689     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120772     Document Type: Article

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