NESdb: A database of NES-containing CRM1 cargoes

Molecular Biology of the Cell

Volumn 23, Issue 18, 2012, Pages 3673-3676

  Xu, Darui ^a   Grishin, Nick V ^a   Chook, Yuh Min ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXPORTIN 1;

AMINO ACID SEQUENCE; CELL NUCLEUS; HUMAN; MUTATION; NON PROFIT ORGANIZATION; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DATA BANK; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; REVIEW;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID SEQUENCE; ANIMALS; CELL NUCLEUS; DATABASES, PROTEIN; HUMANS; INTERNET; KARYOPHERINS; MOLECULAR SEQUENCE DATA; NUCLEAR EXPORT SIGNALS; PROTEIN BINDING; PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

EID: 84866422549     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E12-01-0045     Document Type: Review

References (42)

1. Bogerd HP, Fridell RA, Benson RE, Hua J, Cullen BR (1996). Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Mol Cell Biol 16, 4207-4214. (Pubitemid 26251221)
2. Bogerd HP, Fridell RA, Madore S, Cullen BR (1995). Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell 82, 485-494.
3. Chook YM, Blobel G (2001). Karyopherins and nuclear import. Curr Opin Struct Biol 11, 703-715.
4. Conti E, Izaurralde E (2001). Nucleocytoplasmic transport enters the atomic age. Curr Opin Cell Biol 13, 310-319. (Pubitemid 32429495)
5. Dong X, Biswas A, Chook YM (2009a). Structural basis for assembly and disassembly of the CRM1 nuclear export complex. Nat Struct Mol Biol 16, 558-560.
6. Dong X, Biswas A, Süel KE, Jackson LK, Martinez R, Gu H, Chook YM (2009b). Structural basis for leucine-rich nuclear export signal recognition by CRM1. Nature 458, 1136-1141.
7. Engelsma D, Bernad R, Calafat J, Fornerod M (2004). Supraphysiological nuclear export signals bind CRM1 independently of RanGTP and arrest at Nup358. EMBO J 23, 3643-3652. (Pubitemid 39336286)
8. Faustino RS, Nelson TJ, Terzic A, Perez-Terzic C (2007). Nuclear transport: target for therapy. Clin Pharmacol Ther 81, 880-886. (Pubitemid 46788292)
9. Fischer U, Meyer S, Teufel M, Heckel C, Lührmann R, Rautmann G (1994). Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA. EMBO J 13, 4105-4112. (Pubitemid 24275867)
10. Fornerod M, Ohno M, Yoshida M, Mattaj IW (1997). CRM1 is an export receptor for leucine rich nuclear export signals. Cell 90, 1051-1060. (Pubitemid 27408519)
11. Fridell RA, Fischer U, Lührmann R, Meyer BE, Meinkoth JL, Malim MH, Cullen BR (1996). Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev. Proc Natl Acad Sci USA 93, 2936-2940. (Pubitemid 26116248)
12. Fu SC, Imai K, Horton P (2011). Prediction of leucine-rich nuclear export signal containing proteins with NESsential. Nucleic Acids Res 39, e111.
13. Fukuda M, Asano S, Nakamura T, Adachi M, Yoshida M, Yanagida M, Nishida E (1997). CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390, 308-311. (Pubitemid 27513316)
14. Görlich D, Kutay U (1999). Transport between the cell nucleus and the cytoplasm. Annu Rev Cell Dev Biol 15, 607-660. (Pubitemid 32250388)
15. Güttler T, Madl T, Neumann P, Deichsel D, Corsini L, Monecke T, Ficner R, Sattler M, Görlich D (2010). NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol 17, 1367-1376.
16. Henderson BR, Eleftheriou A (2000). A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Exp Cell Res 256, 213-224. (Pubitemid 30211183)
17. Ho JH, Kallstrom G, Johnson AW (2000). Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J Cell Biol 151, 1057-1066.
18. Jain E, Bairoch A, Duvaud S, Phan I, Redaschi N, Suzek BE, Martin MJ, McGarvey P, Gasteiger E (2009). Infrastructure for the life sciences: design and implementation of the UniProt website. BMC Bioinformatics 10, 136.
19. Kudo N, Matsumori N, Taoka H, Fujiwara D, Schreiner EP, Wolff B, Yoshida M, Horinouchi S (1999). Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci USA 96, 9112-9117.
20. Kutay U, Güttinger S (2005). Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol 15, 121-124.
21. la Cour T, Gupta R, Rapacki K, Skriver K, Poulsen FM, Brunak S (2003). NESbase version 1.0: a database of nuclear export signals. Nucleic Acids Res 31, 393-396. (Pubitemid 36150410)
22. la Cour T, Kiemer L, Mølgaard A, Gupta R, Skriver K, Brunak S (2004). Analysis and prediction of leucine-rich nuclear export signals. Protein Eng Des Sel 17, 527-536. (Pubitemid 39487532)
23. Marchler-Bauer A et al. (2009). CDD: specific functional annotation with the Conserved Domain Database. Nucleic Acids Res 37, D205-D210.
24. McGuffin LJ, Bryson K, Jones DT (2000). The PSIPRED protein structure prediction server. Bioinformatics 16, 404-405. (Pubitemid 30417087)
25. Meyer BE, Malim MH (1994). The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm. Genes Dev 8, 1538-1547. (Pubitemid 24218288)
26. Monecke T, Güttler T, Neumann P, Dickmanns A, Görlich D, Ficner R (2009). Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Science 324, 1087-1091.
27. Murdoch K, Loop S, Rudt F, Pieler T (2002). Nuclear export of 5S rRNA-containing ribonucleoprotein complexes requires CRM1 and the RanGTPase cycle. Eur J Cell Biol 81, 549-556. (Pubitemid 35256383)
28. Neville M, Stutz F, Lee L, Davis LI, Rosbash M (1997). The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr Biol 7, 767-775. (Pubitemid 27441831)
29. Noske A, Weichert W, Niesporek S, Röske A, Buckendahl AC, Koch I, Sehouli J, Dietel M, Denkert C (2008). Expression of the nuclear export protein chromosomal region maintenance/exportin 1/Xpo1 is a prognostic factor in human ovarian cancer. Cancer 112, 1733-1743. (Pubitemid 351536833)
30. Ossareh-Nazari B, Bachelerie F, Dargemont C (1997). Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278, 141-144.
31. Pearson WR, Lipman DJ (1988). Improved tools for biological sequence comparison. Proc Natl Acad Sci USA 85, 2444-2448.
32. Pei J, Grishin NV (2001). AL2CO: calculation of positional conservation in a protein sequence alignment. Bioinformatics 17, 700-712. (Pubitemid 32851378)
33. Richards SA, Carey KL, Macara IG (1997). Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein export. Science 276, 1842-1844.
34. Stade K, Ford CS, Guthrie C, Weis K (1997). Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 90, 1041-1050. (Pubitemid 27408518)
35. The UniProt Consortium (2011). Ongoing and future developments at the Universal Protein Resource. Nucleic Acids Res 39, D214-219.
36. Tran EJ, Bolger TA, Wente SR (2007). SnapShot: nuclear transport. Cell 131, 420.
37. Vissinga CS, Yeo TC, Warren S, Brawley JV, Phillips J, Cerosaletti K, Concannon P (2009). Nuclear export of NBN is required for normal cellular responses to radiation. Mol Cell Biol 29, 1000-1006.
38. Weis K (2003). Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle. Cell 112, 441-451.
39. Wen W, Meinkoth JL, Tsien RY, Taylor SS (1995). Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473.
40. Xu D, Farmer A, Chook YM (2010). Recognition of nuclear targeting signals by Karyopherin-β proteins. Curr Opin Struct Biol 20, 782-790.
41. Xu D, Farmer A, Collett G, Grishin NV, Chook YM (2012). Sequence and structural analyses of nuclear export signals in the NESdb database. Mol Biol Cell 23, 3677-3693.
42. Yi R, Bogerd HP, Cullen BR (2002). Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs. J Virol 76, 2036-2042. . (Pubitemid 34150671)