Functional foods for the gut: probiotics, prebiotics and synbiotics

Functional Foods: Concept to Product: Second Edition

Volumn , Issue , 2011, Pages 449-470

  Drakoularakou, A ^a   Rastall, R ^a   Gibson, G ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Dietary intervention; Human gut microbiology; Prebiotic oligosaccharides

Indexed keywords

EID: 84866378025     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1533/9780857092557.3.449     Document Type: Chapter

References (137)

1. Abrams S.A., Griffin I.J., Hawthorne K.M., Liang L., Gunn S.K., et al. A combination of prebiotic short-and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. American Journal of Clinical Nutrition 2005, 82:471-476.
2. Alles M.S., Hartemink R., Meyboom S., Harryvan J.L., Van Laere K., et al. Effect of transgalactooligosaccharides on the composition of the human intestinal microflora and on putative risk markers for colon cancer. American Journal of Clinical Nutrition 1999, 69:980-991.
3. Andersson H.B., Elegard L.H., Bosaeus I.G. Nondigestibility characteristics of inulin and oligofructose in humans. Journal of Nutrition 1999, 129:1428S-1429S.
4. Anon Guidelines for the evaluation of probiotics in food. Joint FAO/WHO working group report on drafting guidelines for the evaluation of probiotics in food 2002.
5. Armuzzi A., Gasbarrini A., Franceschi F., Ojetti V., Candelli M., et al. Efficacy of Lactobacillus GG in decreasing antibiotic-associated gastrointestinal morbidity during H. pylori eradication regimen. Gut 1999, 45(Suppl. 3):121-125.
6. Arvola T., Laiho K., Torkkeli S. Prophylactic Lactobacillus GG reduces antibiotic-associated diarrhea in children with respiratory infections: a randomized study. Pediatrics 1999, 104:64-78.
7. Asahara T., Nomoto K., Shimizu K., Watanuki M., Tanaka R. Increased resistance of mice to Salmonella enterica serovar Typhymurium infection by synbiotic administration of bifidobacteria and transgalactosylated oligosaccharides. Journal of Applied Microbiology 2001, 91:985-996.
8. Bausserman M., Michail S. The use of Lactobacillus GG in irritable bowel syndrome in children: a double-blind randomized control trial. Journal of Pediatrics 2005, 147:197-201.
9. Biedrzycka E., Bielecka M. Prebiotic effectiveness of fructans of different degrees of polymerisation. Trends Food Sci Technol 2004, 15:255-267.
10. Boehm G., Lidestri M., Casetta P., Jelinek J., Negretti F., et al. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of faecal bifidobacteria in preterm infants. Archives of Disease in Childhood: Fetal and Neonatal 2002, 86:178-181.
11. Bouhnik Y., Flourie B., D'Agay-Abensour L., Pochart P., Gramet G., et al. Administration of transgalacto-oligosaccharides increases fecal bifidobacteria and modifies colonic fermentation metabolism in healthy humans. Journal of Nutrition 1997, 127:444-448.
12. Boutron-Ruault M.C., Marteau P., Lavergne-Slove A., Myara A., Gerhardt M.F. Effects of a 3-mo consumption of short-chain fructo-oligosaccharides on parameters of colorectal carcinogenesis in patients with or without small or large colorectal adenomas. Nutrition and Cancer 2005, 53:160-168.
13. Bufill J. Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Annals of Internal Medicine 1990, 113:779-788.
14. Campbell J.H., Fahey G.C., Wolf B.W. Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats. Journal of Nutrition 1997, 127:130-136.
15. Prebiotics and Probiotics Science and Technology 2009, Springer, New York. D. Charalampopoulos, R.A. Rastall (Eds.).
16. Cherbut C. Inulin and oligofructose in the dietary fibre concept. British Journal of Nutrition 2002, 87(Supplement 2):S159-S162.
17. Cherbut C., Michel C., Lecannu G. The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats. Journal of Nutrition 2003, 133:21-27.
18. Chourasia M., Jain S. Pharmaceutical approaches to colon targeted drug delivery systems. Journal of Pharmacy and Pharmacology 2002, 6:33-66.
19. Chung C.H., Day D.F. Glucooligosaccharides from Leuconostoc mesenteroides B-742 (ATCC 13146): a potential prebiotic. Journal of Industrial Microbiology and Biotechnology 2002, 29:186-199.
20. Cremonini F., Di Caro S., Nista E.C. Meta-analysis: The effect of probiotic administration on antibiotic associated diarrhea. Alimentary Pharmacology Therapies 2002, 16:1461-1467.
21. Crogan N.L., Evans B.C. Clostridium difficile: an emerging epidemic in nursing homes. Geriatric Nursing 2007, 28:161-164.
22. Crittenden R.G., Playne M.J. Production, properties and applications of food-grade oligosaccharides. Trends in Food Science and Technology 1996, 7:353-361.
23. Culligan E.P., Hill C., Sleator R.D. Probiotics and gastrointestinal disease: successes, problems and future prospects. Gut Pathogens 2009, 1:19-30.
24. Cummings J.H., Christie S., Cole T.J. A study of fructo oligosaccharides in the prevention of travellers' diarrhoea. Alimentary Pharmacology Therapy 2001, 15:1139-1145.
25. Cummings J.H., Macfarlane G.T., Drasar B.D. The gut microflora and its significance. Gastrointestinal Pathology 1989, Churchill-Livingstone, Edinburgh. R. Whitehead (Ed.).
26. Cummings J.H., Macfarlane G.T., Enlglyst H.N. Prebiotic digestion and fermentation. American Journal of Clinical Nutrition 2001, 73:415S-420S.
27. Davidson M.H., Maki K.C. Effects of dietary inulin on serum lipids. Journal of Nutrition 1999, 129:1474S-1477S.
28. Deguchi Y., Morishita T., Mutai M. Comparative studies on synthesis of water-soluble vitamins among human species of bifidobacteria. Agricultural and Biological Chemistry 1985, 49:13-19.
29. Depeint F., Tzortzis G., Vulevic J., I'anson K., Gibson G.R. Prebiotic evaluation of a novel galactooligosaccharide mixture produced by the enzymatic activity of Bifidobacterium bifidum NCIMB 41171, in healthy humans: a randomized, doubleblind, crossover, placebo-controlled intervention study. American Journal of Clinical Nutrition 2008, 87:785-791.
30. Drakoularakou A., Tzortzis G., Rastall R.A., Gibson G.R. A double-blind, placebo-controlled, randomized human study assessing the capacity of a novel galacto-oligosaccharide mixture in reducing travellers' diarrhoea. European Journal of Clinical Nutrition 2010, 64:146-152.
31. Drossman D.A., Camilleri M., Mayer E.A., Whitehead W.E. AGA technical review on irritable bowel syndrome. Gastroenterology 2003, 123:2108-2131.
32. Ellegard L., Andersson H., Bosaeus I. Inulin and oligofructose do not influence the absorption of cholesterol, or the excretion of cholesterol, Ca, Mg, Zn, Fe or bile acids but increases energy excretion in ileostomy subjects. European Journal of Clinical Nutrition 1997, 51:1-5.
33. Flickinger E.A., Fahey G.C. Pet food and feed applications of inulin, oligofructose and other oligosaccharides. British Journal of Nutrition 2002, 87:S297-S300.
34. Fuchs A. Production and utilization of inulin. Science and Technology of Fructans 1993, 319-352. CRC Press, Boca Raton, FL. M. Suzuki, N. Chatterton (Eds.).
35. Fuller R. Probiotics in man and animals. Journal of Applied Bacteriology 1989, 66:356-378.
36. Furrie E., Macfarlane S., Kennedy A., Cummings J.H., Walsh S.V., et al. Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial. Gut 2005, 54:242-249.
37. Gibson G.R. Dietary modulation of the human gut microbiota using prebiotics. British Journal of Nutrition 1998, 80(4):S209-S210.
38. Gibson G.R., McCartney A.L. Modifications ofthe gutfloraby dietary means. Biochemical Society Transactions 1998, 26:222-228.
39. Prebiotics: Development and Application 2006, John Wiley and Sons Ltd, Chichester. G.R. Gibson, R.A. Rastall (Eds.).
40. A Handbook of Prebiotics 2008, Taylor and Francis, Boca Raton. G.R. Gibson, M.B. Roberfroid (Eds.).
41. Gibson G.R., Roberfroid M.B. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 1995, 125:1401-1412.
42. Colonic Microbiota, Nutrition and Health 1999, Kluwer Academic Publishers, Dordrecht, the Netherlands. G.R. Gibson, M.B. Roberfroid (Eds.).
43. Gibson G.R., Wang X. Enrichment of bifidobacteriafromhumangutcontents by oligofructose using continuous culture. FEMS Microbiology Letters 1994, 118:121-128.
44. Gibson G.R., Beatty E.R., Wang X., Cummings J.H. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 1995, 108(4):975-982.
45. Gibson G.R., Ottaway P.B., Rastall R.A. Prebiotics: New Developments in Functional Foods 2001, Chadwick House Group Ltd, UK.
46. Gibson G.R., Probert H.M., Van Loo J., Rastall R.A., Roberfroid M.B. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutrition Research Reviews 2004, 17:259-275.
47. Gionchetti P., Rizzello F., Helwig U., Venturi A., Lammers K.M., et al. Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 2003, 124(5):1535-1538.
48. Guandalini S., Pensabene L., Zikri M.A. Lactobacillus GG administered in oral rehydration solution to children with acute diarrhea: a multicenter European trial. Journal of Pediatric Gastroenterology and Nutrition 2000, 30:54-60.
49. Guarner F. Enteric flora in health and disease. Digestion 2006, 73(suppl. 1):5-12.
50. Guigoz Y., Rochat F., Perruisseau-Carrier G., Rochat I., Schriffen E. Effects of oligosaccharides on the faecal flora and non-specfic immune system in elderly people. Nutrition Research 2002, 22:13-25.
51. Harmsen H.M.J., Raangs G.C., He T., Degener J.E., Welling G.W. Extensive set of 16S rRNA probes for detection of bacteria in human faeces. Applied and Environmental Microbiology 2002, 68(2):2982-2990.
52. Hellwege E.M., Czapla S., Jahnke A., Willmitzer L., Heyer A.G. Transgenic potato (Solanum tuberosum) tubers synthesize the full spectrum of inulin molecules naturally occurring in globe artichoke (Cynara scolymus) roots. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:8699-8704.
53. Hopkins M.J., Macfarlane G.T. Nondigestible oligosaccharides enhance bacterial colonisation resistance against Clostridium difficile in vitro. Applied and Environmental Biology 2003, 69:1920-1927.
54. Hoveyda N., Heneghan C., Mahtani K.R., Perera R., Roberts N., Gasziou P. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterology 2009, 9:15-25.
55. Hylla S., Gostner A., Dusel G., Anger H., Bartram H., et al. Effects of resistant starch on the colon in healthy volunteers: possible implications for cancer prevention. American Journal of Clinical Nutrition 1998, 67:136-142.
56. International Scientific Association for Probiotics and Prebiotics (ISAPP) 6th Meeting of the International Scientific Association of Probiotics and Prebiotics 2008, Ontario, London.
57. Ito M., Deguchi Y., Matsumoto K., Kimura M., Onodera N., Yajima T. Influence of galactooligosaccaharides on the human fecal microflora. Journal of Nutritional Science and Vitaminology 1993, 39:635-640.
58. Jenkins D.J., Kendall C., Vuksan V. Inulin, oligofructose and intestinal function. Journal of Nutrition 1999, 129:1431S-1433S.
59. Kaplan H., Hutkins R.W. Fermentation of fructooligosaccharides by lactic acid bacteria and bifidobacteria. Applied and Environmental Microbiology 2000, 66(6):2682-2684.
60. Kim H.J., Vazquez Roque M.I., Camilleri M., Stephens D., Burton D.D., et al. A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating. Neurogastroenterology Motility 2005, 17:687-696.
61. Kleessen B., Hartman L., Blaut M. Oligofructose and long chain inulin influence the gut microbial ecology of rats associated with human faecal flora. British Journal of Nutrition 2001, 86:291-300.
62. Kleessen B., Sykura B., Zunft H.J., Blaut M. Effects of inulin and lactose on faecal microflora, microbial activity, and bowel habit in elderly constipated persons. American Journal of Clinical Nutrition 1997, 65:1397-1402.
63. Kolida S., Tuohy K., Gibson G.R. Prebiotic effects of inulin and oligofructose. British Journal of Nutrition 2002, 87:S193-S197.
64. Konikoff M.R., Denson L.A. Role of fecal calprotectin as a biomarker of intestinal inflammation in inflammatory bowel disease. Inflammatory Bowel Disease 2006, 12:524-534.
65. Kruse H.P., Kleessen B., Blaut M. Effects of inulin on faecal bifidobacteria in human subjects. British Journal of Nutrition 1999, 82(5):375-382.
66. Lewis S., Burmeister S., Brazier J. Effect ofthe prebiotic oligofructose on relapse of Clostridium difficile, associated diarrhea: a randomized, controlled study. Clinical Gastroenterology Hepatology 2005, 3:442-448.
67. Lilly D.M., Stillwell R.H. Probiotics: growth promoting factors produced by microorganisms. Science 1965, 147:747-748.
68. Lindsay J.O., Whelan K., Stagg A.J., Gobin P., Al-Hassi H.O. Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease. Gut 2006, 55:348-355.
69. Lomax A.R., Calder P.C. Probiotics, immune function, infection and inflammation: a review of the evidence from studies conducted in humans. Current Pharmaceutical Design 2009, 15(13):128-151.
70. Lopez-Molina D., Navarro-Martinez M.D., Rojas-Melgarejo F., Hiner A., Chazarra S., Rodriguez-Lopez J.N. Molecular properties and prebiotic effects of inulin obtained from artichoke. Phytochemistry 2005, 66:1476-1484.
71. Lupton J.R., Kurtz P.P. Relationship of colonic luminal short-chain fatty acids and pH to in vivo cell proliferation in rats. Journal of Nutrition 1993, 123:1522-1530.
72. Macfarlane G.T., Gibson G.R., Cummings J.H. Comparison of fermentation reactions in different regions of the human colon. J. Applied Bacteriology 1992, 72:57-64.
73. Marx S.P., Winkler S., Hartmeier W. Metabolisation of β-(2,6)-linked fructose-oligosaccharides by different bacteria. FEMS Microbiol Lett 2000, 192:163-169.
74. McFarland L.V. A review of the evidence of health claims for biotherapeutic agents. Microbial Ecology in Health and Disease 2000, 12:65-76.
75. McFarland L.V. Meta-analysis of probiotics for the prevention of traveller's diarrhea. Travel Medicine and Infectious Disease 2007, 5(2):97-105.
76. McFarland L.V. Evidence-based review of probiotics for antibiotic-associated diarrhea and Clostridium difficile infections. Anaerobe 2009, 5:274-280.
77. Menne E., Guggenbuhl N., Roberfroid M. Fn-type chicory inulin hydrolyzate has a prebiotic effect in humans. Journal of Nutrition 2000, 130:197-199.
78. Metchnikoff E. The Prolongation of Life 1907, William Heinemann, London.
79. Moerman F.T., Van Leeuwen M.B., Delcour J.A. Enrichment of higher molecular weight fractions in inulin. Journal of Agricultural and Food Chemistry 2004, 52:3780-3783.
80. Molis C., Flourie B., Ouarne F., Gailing M.F., Lartigue S., Guibert A., Bornet F., Galmiche J.P. Digestion, excretion, and energy value of fructooligosaccharides in healthy humans. American Journal of Clinical Nutrition 1996, 64(3):324-328.
81. Moro G., Stahl B., Fanaro S., Jelinek J., Boehm G., Coppa G. Dietary prebiotic oligosaccharides are detectable in the faeces of formula-fed infants. Acta Paediactrica 2005, 94:27-30.
82. Nakakuki T. Development of functional oligosaccharides in Japan. Advanced Dietary Fibre Technology 2003, 15(82):57-64.
83. Nobaek S., Johansson M.L., Molin G., Ahrné S., Jeppsson B. Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. American Journal of Gastroenterology 2000, 95:1231-1238.
84. Olano-Martin E., Mountzouris K., Gibson G.R., Rastall R. In vitro fermentability of dextran, oligodextran and maltodextran by human gut bacteria. British Journal of Nurition 2000, 83:247-255.
85. O'Mahony L., McCarthy J., Kelly P., Hurley G., Luo F., et al. Lactobacillus and Bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles. Gastroenterology 2005, 128:541-551.
86. Ouwehand A., Kurvinen T., Päivi Rissanen P. Use of a probiotic Bifidobacterium in a dry food matrix, an in vivo study. International Journal of Food Microbiology 2004, 95:103-106.
87. Ouwehand A.C., Kirjavainen P.V., Shortt C., Salminen S. Probiotics: mechanisms and established effects. International Dairy Journal 1999, 9:43-52.
88. Parker R.B. Probiotics: the other half of the antibiotic story. Animal Nutrition and Health 1974, 29:4-8.
89. Parnell J.A., Reimer R.A. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. American Journal of Clinical Nutrition 2009, 89:1751-1759.
90. Press A.G., Hauptmann I.A., Hauptmann L., Fuchs B., Ramadori G. Gastrointestinal pH profiles in patients with inflammatory bowel disease. Alimentary Pharmacology and Therapeutics 1998, 12:673-678.
91. Rabiu B., Jay A., Gibson G.R., Rastall R.A. Synthesis and fermentation properties of novel galacto-oligosaccharides by [beta]-galactosidases from Bifidobacterium species. Applied and Environmental Microbiology 2001, 67:2526-2530.
92. Rafter J., Bennett M., Caderni G., Clune Y., Hughes R. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. American Journal of Clinical Nutrition 2007, 85:488-496.
93. Rao V. The prebiotic properties of oligofructose at low intake levels. Nutrition Research 2001, 21:843-848.
94. Rathbone B.J., Heatley R.V. Helicobacterpylori and Gastroduodenal Disease 1992, Blackwell Scientific Publications, Oxford. 2nd edn.
95. Reid G., Jass J., Sebulsky M.T., McCormick J.K. Potential uses of probiotics in clinical practice. Clinical Microbiology Reviews 2003, 16(4):658-672.
96. Roberfroid M.B. Prebiotics and synbiotics: concepts and nutritional properties. Br. J. Nutr 1998, 130:S396-S402.
97. Roberfroid M.B. Caloric value of inulin and oligofructose. Journal of Nutrition 1999, 129:1436S-1437S.
98. Roberfroid M.B. Probiotics and prebiotics: are they functional foods?. American Journal of Clinical Nutrition 2000, 71:S1682-S1687.
99. Roberfroid M.B. Functional foods: concepts and application to inulin and oligofructose. British Journal of Nutrition 2002, 87(Suppl. 2):S139-S143.
100. Roberfroid M.B. Prebiotics: the concept revisited. Journal of Nutrition 2007, 137:830S-837S.
101. Roberfroid M.B., Van Loo F., Gibson G.R. The bifidogenic nature ofchicory inulin and oligofructose. Journal of Nutrition 1998, 128:11-19.
102. Roediger W.E. The colonic epithelium in ulcerative colitis: an energy-deficiency disease?. Lancet 1980, 2:712-715.
103. Rowland I.R., Rumney C.J., Coutts J.T., Lievense L.C. Effect of Bifidobacterium longum and inulin on gut bacterial metabolism and carcinogen-induced aberrant crypt foci in rats. Carcinogenesis 1998, 19:281-285.
104. Rowland I.R., Tanaka R. The effects of transgalactosylated oligosaccharides on gut flora metabolism in rats associated with a human faecal microflora. Journal of Applied Bacteriology 1993, 74:667-674.
105. Saavendra J.M., Tschemia A. Human studies with probiotics and prebiotics: clinical implications. British J. Nutr 2002, 87:S241-S246.
106. Sako T., Matsumoto K., Tanaka R. Recent progress on research and applications of non-digestible galacto-oligosaccharides. International Dairy Journal 1999, 9:69-80.
107. Salminen A.C., Bouley C., Boutron-Ruault M.C., Cummings J.H., Frank A., et al. Functional food science and gastrointestinal physiology and function. British Journal of Nutrition 1998, 80(Suppl. 1):S147-S171.
108. Salminen E., Ouwehand A., Benno Y., Lee Y.K. Probiotics: howthey should be defined?. Trends in Food Science and Technology 1999, 10:107-110.
109. Sangeetha P.T., Ramesh M.N., Prapulla S.G. Recent trends in the microbial production, analysis and application of fructooligosaccharides. Trends Food Sci. Technol 2005, 16:442-457.
110. Schaafsma G., Meuling W., van Dokkum W., Bouley C. Effects of a milk product, fermented with Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. European Journal of Clinical Nutrition 1998, 52:436-440.
111. Servin A.L. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiology Reviews 2004, 28:405-440.
112. Shiba T., Aiba Y., Ishikawa H., Ushiyama A., Takagi A., et al. The suppressive effect of bifidobacteria on Bacteroides vulgaris, a putative pathogenic microbe in inflammatory bowel disease. Microbiology and Immunology 2003, 47:371-378.
113. Shoaf K., Mulvey G., Armstrong G., Hutkins R. Prebiotic galactooligosaccharides reduce adherence of enteropathogenic Escherichia coli to tissue culture cells. Infection and Immunity 2006, IAI.01030-06.
114. Silk D.B., Davis A., Vulevic J., Tzortzis G., Gibson G.R. Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Alimentary Pharmacology and Therapy 2009, 29:508-518.
115. Sperti G.S. Probiotics 1971, Avi Publishing Co, West Point, CT.
116. Szilagyi A., Rivard J., Shrier I. Diminished efficacy ofcolonic adaptation to lactulose occurs in patients with Inflammatory Bowel Disease in remission. Digestive Diseases and Sciences 2002, 47:2811-2822.
117. Takahashi O., Noguchi Y., Omata F., Tokuda Y., Fakui Y. Probiotics in the prevention of traveler's diarrhea: meta-analysis. Journal of Clinical Gastroenterology 2007, 41(3):336-337.
118. Tanaka R., Takayama H., Morotomi M., Kuroshima T., Ueyama S., et al. Effects of administration of TOS and Bifidobacterium breve 4006 on the human fecal microflora. Bifidobacteria Microflora 1983, 2:17-24.
119. Probiotics and Prebiotics 2002, Caister Academic Press, Norfolk. G. Tannock (Ed.).
120. Tong J.L., Ran Z.H., Shen J., Zhang C.X., Xiao S.D. Meta-analysis: the effect of supplementation with prebiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Alimentary Pharmocology and Therapeutics 2007, 25(2):155-168.
121. Topping D.L., Clifton P.M. Short chain fatty acids and human colonic function: roles of resistant starch and non-starch polysaccharides. Physiological Reviews 2001, 81(3):1031-1063.
122. Tungland B.C., Meyer D. Nondigestible oligo-and polysaccharides (dietary fiber): their physiology and role in human health and food. Comprehensive Reviews in Food Science and Food Safety 2002, 1:73-92.
123. Tuohy K.M., Finlay R.K., Wynne A.G., Gibson G.R. A human volunteer study on the effects of HP-inulin-gut bacteria enumerated using FISH. Anaerobe 2001, 7:113-118.
124. Tuohy K.M., Kolida S., Lustenberger A., Gibson G.R. The prebiotic effects of biscuits containing partially hydrolysed guar gum and fructooligosaccharides-a human volunteer study. British Journal of Nutrition 2001, 86:341-348.
125. van Nuenen M., Meyer P., Venema K. The effect of various inulins and Clostridium difficile on the metabolic activity of the human colonic microbiota in vitro. Microbial Ecology in Health and Disease 2003, 15:137-144.
126. Venturi A., Gionchetti P., Rizzello F., Johansson R., Zucconi E., et al. Impact on the composition of the faecal flora by a new probiotic preparation: preliminary data on maintenance treatment of patients with ulcerative colitis. Alimentary Pharmacology Therapy 1999, 13:1103-1108.
127. Therapeutic Microbiology 2008, ASM Press, Washington. J. Versalovic, M. Wilson (Eds.).
128. Vulevic J., Drakoularakou A., Yaqoob P., Tzortzis G., Gibson G.R. Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. American Journal of Clinical Nutrition 2008, 88:1438-1446.
129. Waligora-Dupriet A.J., Campeotto F., Nicolis I., Bonet A., Soulaines P., et al. Effect of oligofructose supplementation on gut microflora and well-being in young children attending a day care centre. International Journal of Food Microbiology 2007, 113:108-113.
130. Wang X., Gibson G.R. Effects ofthe in vivo fermentation ofoligofructose and inulin by bacteria growing in the human large intestine. Journal of Applied Bacteriology 1993, 75(4):373-380.
131. Welters C.F., Heineman E., Thunnissen F.B., van den Bogaard A.E., Soeters P.B., Baeten C.G. Effect of dietary inulin supplementation on inflammation ofpouch mucosa in patients with an ileal pouch-anal anastomosis. Diseases of the Colon and Rectum 2002, 45:621-627.
132. Wichienchot S., Prasertsan P., Hongpattarakere T., Gibson G.R., Rastall R. In vitro fermentation of mixed linkage glucooligosaccharides produced by gluconobacter oxydans NCIMB 4943 by the human colonic micoflora. Current Issues in Intestinal Microbiology 2006, 7:7-12.
133. Wohlgemuth S., Loh G., Blaut M. Recent developments and perspectives in the investigation of probiotic effects. International Journal of Medical Microbiology 2009, 300(1):3-10.
134. Wult M., Hagslatt M.L., Odenholt I. Lactobacillusplantarum forthetreatment of recurrent Clostridium difficile diarrhoea: a double-blind, placebo-controlled trial. Scandinavian Journal of Infections Diseases 2003, 35:365-367.
135. Yan F., Polk D.B. Commensal bacteria in the gut: learning who our friends are. Current Opinion in Gastroenterology 2004, 20:565-567.
136. Yazawa K., Imai K., Tamura Z. Oligosaccharides and polysaccharides specifically utilizable by bifidobacteria. Chemical and Pharmaceutical Bulletin 1978, 26:3306-3311.
137. Yazawa K., Tamura Z. Search for sugar sources for selective increase of bifidobacteria. Bifidobacteria Microflora 1982, 1:39-44.