Nondigestible oligosaccharides enhance bacterial colonization resistance against Clostridium difficile in vitro

Applied and Environmental Microbiology

Volumn 69, Issue 4, 2003, Pages 1920-1927

  Hopkins, Mark J ^a   Macfarlane, George T ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; STRAIN; TOXICITY;

COLONIZATION;

MICROBIOLOGY;

CLINDAMYCIN; CYTOTOXIN; INULIN; OLIGOMATE 55; OLIGOSACCHARIDE; PROBIOTIC AGENT; RAFTILINE LS; RAFTILOSE P95; SHORT CHAIN FATTY ACID;

ANTIBIOTICS; BACTERIAL DISEASE; DIARRHEAL DISEASE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTEROIDES; BIFIDOBACTERIUM; CHEMOSTAT; CLOSTRIDIUM DIFFICILE; COMMUNITY STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DIARRHEA; FATTY ACID SYNTHESIS; FECES CULTURE; IN VITRO STUDY; INFECTION RESISTANCE; NONHUMAN; PSEUDOMEMBRANOUS COLITIS;

ANTI-BACTERIAL AGENTS; ANTIBIOSIS; BIFIDOBACTERIUM; CLINDAMYCIN; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; COLONY COUNT, MICROBIAL; CULTURE MEDIA; DNA, RIBOSOMAL; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FECES; HUMANS; OLIGOSACCHARIDES; PROBIOTICS; RNA, RIBOSOMAL, 16S; SEQUENCE ANALYSIS, DNA;

BACTERIA (MICROORGANISMS); BACTEROIDES; BIFIDOBACTERIUM; CLOSTRIDIUM; CLOSTRIDIUM DIFFICILE; POSIBACTERIA;

EID: 0037392977     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.69.4.1920-1927.2003     Document Type: Article

References (48)

1. Amann, R. I., B. J. Binder, R. J. Olson, S. W. Chisholm, R. Devereux, and D. A. Stahl. 1990. Combination of 16S rRNA-targeted oligonucleotide probes with flow cytometry for analyzing mixed microbial populations. Appl. Environ. Microbiol. 56:1919-1925.
2. Arzese, A., P. Corradino, and G. A. Botta. 1990. Effect of short chain fatty acids on growth and toxin production of pathogenic clostridia, p. 178. In S. P. Borriello (ed.). Clinical and molecular aspects of anaerobes. Wrightson Biomedical, Petersfield, England.
3. Balch, W. E., G. E. Fox, L. J. Magrum, C. R. Woese, and R. S. Wolfe. 1979. Methanogens: reevaluation of a unique biological group. Microbiol. Rev. 43:260-296.
4. Beerens, H. 1991. Elective and selective isolation medium for Bifidobacterium spp. Lett. Appl. Microbiol. 11:155-157.
5. Borriello, S. P., and F. E. Barclay. 1986. An in-vitro model of colonisation resistance to Clostridium difficile infection. J. Med. Microbiol. 21:299-309.
6. Borriello, S. P., and M. H. Wilcox. 1998. Clostridium difficile infections of the gut: the unanswered questions. J. Antimicrob. Chemother. 41S:C67-C69.
7. Brown, R. L., J. A. Gibson, G. E. Sladen, B. Hicks, and A. M. Dawson. 1974. Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Gut 15:999-1004.
8. Cohen, M. B., and R. A. Giannella. 1991. Bacterial infections: pathophysiology, clinical features, and treatment, p. 395-428. In S. F. Phillips, J. H. Pemberton, and R. G. Shorter (ed.), The large intestine: physiology, pathophysiology and disease. Raven Press, New York, N.Y.
9. Cummings, J. H., E. W. Pomare, W. J. Branch, C. P. Naylor, and G. T. Macfarlane. 1987. Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28:1221-1227.
10. Dore, J., A. Sghir, G. Hannequart-Gramet, G. Corthier, and P. Pochart. 1998. Design and evaluation of a 16S rRNA-targeted oligonucleotide probe for specific detection and quantitation of human faecal Bacteroides populations. Syst. Appl. Microbiol. 21:65-71.
11. D'Souza, A. L., C. Rajkumar, J. Cooke, and C. J. Bulpitt. 2002. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ 324:1361.
12. Flourie, B., C. Florent, J. P. Jouany, P. Thivend, F. Etanchaud, and J. C. Rambaud. 1986. Colonic metabolism of wheat starch in healthy humans. Effects on fecal outputs and clinical symptoms. Gastroenterology 90:111-119.
13. Gaskins, H. R., R. I. Mackie, T. May, and K. A. Garleb. 1996. Dietary fructo-oligosaccharide modulates large intestinal inflammatory responses to Clostridium difficile in antibiotic-compromised mice. Microb. Ecol. Health Dis. 9:157-166.
14. Gibson, G. R., E. R. Beatty, X. Wang, and J. H. Cummings. 1995. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology. 108:975-982.
15. Gumerlock, P. H., Y. J. Tang, F. J. Meyers, and J. Silva, Jr. 1991. Use of the polymerase chain reaction for the specific and direct detection of Clostridium difficile in human feces. Rev. Infect. Dis. 13:1053-1060.
16. Harmsen, H. J., A. C. Wildeboer-Veloo, G. C. Raangs, A. A. Wagendorp, N. Klijn, J. G. Bindels, and G. W. Welling. 2000. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J. Pediatr. Gastroenterol. Nutr. 30:61-67.
17. Holdeman, L., E. P. Cato, and W. E. C. Moore. 1977. Anaerobe laboratory manual, 4th ed. Virginia Polytechnic Institute and State University, Blacksburg.
18. Hopkins, M. J., R. Sharp, and G. T. Macfarlane. 2001. Age and disease related changes in intestinal bacterial populations assessed by cell culture, 16S rRNA abundance, and community cellular fatty acid profiles. Gut 48:198-205.
19. Ito, M., Y. Deguchi, A. Miyamori, K. Matsumoto, H. Kikuch, K. Matsumoto, T. Kobayashi, T. Yajima, and T. Kan. 1990. Effects of administration of galactooligosaccharides on the human faecal microflora, stool weight and abdominal sensation. Microb. Ecol. Health Dis. 3:285-292.
20. Ito, Y., H. Moriwaki, Y. Muto, N. Kato, K. Watanabe, and K. Ueno. 1997. Effect of lactulose on short-chain fatty acids and lactate production and on the growth of faecal flora, with special reference to Clostridium difficile. J. Med. Microbiol. 46:80-84.
21. Kleessen, B., B. Sykura, H. J. Zunft, and M. Blaut. 1997. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am. J. Clin. Nutr. 65:1397-1402.
22. Kolida, S., K. Tuohy, and G. R. Gibson. 2002. Prebiotic effects of inulin and oligofructose. Br. J. Nutr. 87(Suppl. 2):193-217.
23. Macfarlane, G. T., J. H. Cummings, and C. Allison. 1986. Protein degradation by human intestinal bacteria. J. Gen. Microbiol. 132:1647-1656.
24. Macfarlane, G. T., G. R. Gibson, and J. H. Cummings. 1992. Comparison of fermentation reactions in different regions of the human colon. J. Appl. Bacteriol. 72:57-64.
25. Macfarlane, S., M. E. Quigley, M. J. Hopkins, D. F. Newton, and G. T. Macfarlane. 1998. Polysaccharide degradation by human intestinal bacteria during growth under multi-substrate limiting conditions in a three-stage continuous culture system. FEMS Microbiol. Ecol. 26:231-243.
26. Marteau, P., P. Pochart, J. Dore, C. Bera-Maillet, A. Bernalier, and G. Corthier. 2001. Comparative study of bacterial groups within the human cecal and fecal microbiota. Appl. Environ. Microbiol. 67:4939-4942.
27. May, T., R. I. Mackie, G. C. Fahey, Jr., J. C. Cremin, and K. A. Garleb. 1994. Effect of fiber source on short-chain fatty acid production and on the growth and toxin production by Clostridium difficile. Scand. J. Gastroenterol. 29:916-922.
28. Microbial ID. 1992. Microbial identification system operational manual. Microbial ID Inc., Newark, Del.
29. Naaber, P., K. Klaus, E. Sepp, B. Bjorksten, and M. Mikelsaar. 1997. Colonization of infants and hospitalized patients with Clostridium difficile and lactobacilli. Clin. Infect. Dis. 25(Suppl. 2):S189-S190.
30. Oli, M. W., B. W. Petschow, and R. K. Buddington. 1998. Evaluation of fructooligosaccharide supplementation of oral electrolyte solutions for treatment of diarrhea: recovery of the intestinal bacteria. Dig. Dis. Sci. 43:138-147.
31. Roffe, C. 1996. Biotherapy for antibiotic-associated and other diarrhoeas. J. Infect. 32:1-10.
32. Rolfe, R. D. 1984. Role of volatile fatty acids in colonization resistance to Clostridium difficile. Infect. Immun. 45:185-191.
33. Rolfe, R. D., S. Helebian, and S. M. Finegold. 1981. Bacterial interference between Clostridium difficile and normal fecal flora. J. Infect. Dis. 143:470-475.
34. Rumney, C. J., and I. R. Rowland. 1992. In vivo and in vitro models of the human colonic flora. Crit. Rev. Food Sci. Nutr. 31:299-331.
35. Russell, J. B., and F. Diez-Gonzalez. 1998. The effects of fermentation acids on bacterial growth. Adv. Microb. Physiol. 39:205-234.
36. Sghir, A., J. M. Chow, and R. I. Mackie. 1998. Continuous culture selection of bifidobacteria and lactobacilli from human faecal samples using fructooligosaccharide as selective substrate. J. Appl. Microbiol. 85:769-777.
37. Sghir, A., G. Gramet, A. Suau, V. Rochet, P. Pochart, and J. Dore. 2000. Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization. Appl. Environ. Microbiol. 66:2263-2266.
38. Sharp, R., S. Fishbain, and G. T. Macfarlane. 2001. Effect of short-chain carbohydrates on human intestinal bifidobacteria and Escherichia coli in vitro. J. Med. Microbiol. 50:152-160.
39. Stark, P. L., and A. Lee. 1982. The microbial ecology of the large bowel of breast-fed and formula-fed infants during the first year of life. J. Med. Microbiol. 15:189-203.
40. Tvede, M., and J. Rask-Madsen. 1989. Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients. Lancet i:1156-1160.
41. Vanderhoof, J. A., and R. J. Young. 1998. Use of probiotics in childhood gastrointestinal disorders. J. Pediatr. Gastroenterol. Nutr. 27:323-332.
42. van der Waaij, D. 1988. Evidence of immunoregulation of the composition of intestinal microflora and its practical consequences. Eur. J. Clin. Microbiol. Infect. Dis. 7:103-106.
43. van der Waaij, D., J. M. Berghuis-de Vries, and L.-V. Lekkerkerk. 1971. Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J. Hyg. (London) 69:405-411.
44. Wilson, K. H. 1993. The microecology of Clostridium difficile. Clin. Infect. Dis. 16(Suppl. 4):S214-S218.
45. Wilson, K. H., R. Blitchington, B. Hindenach, and R. C. Greene. 1988. Species-specific oligonucleotide probes for rRNA of Clostridium difficile and related species. J. Clin. Microbiol. 26:2484-2488.
46. Wilson, K. H., and R. Freter. 1986. Interaction of Clostridium difficile and Escherichia coli with microfloras in continuous-flow cultures and gnotobiotic mice. Infect. Immun. 54:354-358.
47. Wilson, K. H., and J. N. Sheagren. 1983. Antagonism of toxigenic Clostridium difficile by nontoxigenic C. difficile. J. Infect. Dis. 147:733-736.
48. Wolf, B. W., J. A. Meulbroek, K. P. Jarvis, and K. A. Garleb. 1995. Effect of dietary supplementation with fructooligosaccharides on survival time in a hamster model of Clostridium difficile colitis, p. 23. In Proceedings of the First International Conference on the Molecular Genetics and Pathogenesis of the Clostridia. American Society for Microbiology, Washington, D.C.