Dual D2-receptor and β2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2- aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues [2]

Journal of Medicinal Chemistry

Volumn 41, Issue 25, 1998, Pages 4915-4917

  Bonnert, R V ^a   Brown, R C ^a   Chapman, D ^a   Cheshire, D R ^a   Dixon, J ^a   Ince, F ^a   Kinchin, E C ^a   Lyons, A J ^a   Davis, A M ^a   Hallam, C ^a   Harper, S T ^a   Unitt, J F ^a   Dougall, I G ^a   Jackson, D M ^a   McKechnie, K ^a   Young, A ^a   Simpson, W T ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6,7 DIHYDROXYTETRALIN; 7 (2 AMINOETHYL) 4 HYDROXYBENZOTHIAZOL 2(3H) ONE; BENZOTHIAZOLE DERIVATIVE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DICYCLOHEXYLCARBODIIMIDE; DOPAMINE 2 RECEPTOR STIMULATING AGENT; IMIDAZOLE DERIVATIVE; PHENYLEPHRINE; PHENYLETHANOLAMINE; SALMETEROL; UNCLASSIFIED DRUG; ANTIASTHMATIC AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; SIBENADET; THIAZOLE DERIVATIVE;

ANIMAL TISSUE; ASTHMA; BRAIN MEMBRANE; CATTLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; EAR ARTERY; GUINEA PIG; LETTER; LIGAND BINDING; NONHUMAN; RABBIT; RECEPTOR INTRINSIC ACTIVITY; RESPIRATORY TRACT DISEASE; TRACHEA; ANIMAL; ARTICLE; BREATHING; BRONCHOSPASM; DOG; DRUG EFFECT; DRUG POTENTIATION; EAR; IN VITRO STUDY; MUCUS; SYNTHESIS; VASCULARIZATION; VASOCONSTRICTION;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANTI-ASTHMATIC AGENTS; BRONCHOCONSTRICTION; DOGS; DOPAMINE AGONISTS; DRUG EVALUATION, PRECLINICAL; EAR; LUNG DISEASES, OBSTRUCTIVE; MUCUS; RABBITS; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, DOPAMINE D2; RESPIRATION; THIAZOLES; VASOCONSTRICTION;

EID: 0032480820     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980421f     Document Type: Letter

References (20)