Comparison of adjustable- and fixed-dose budesonide/formoterol pressurized metered-dose inhaler and fixed-dose fluticasone propionate/salmeterol dry powder inhaler in asthma patients

Journal of Allergy and Clinical Immunology

Volumn 121, Issue 6, 2008, Pages

  Busse, William W ^a   Shah, Shailen R ^b   Somerville, Laura ^c   Parasuraman, Bhash ^d   Martin, Paula ^d   Goldman, Mitchell ^d  

^a University of Wisconsin Health   (United States)

^b Allergy and Asthma Consultants NJ/PA   (United States)

^c Houston Allergy and Asthma Associates   (United States)

^d ASTRAZENECA   (United Kingdom)

Author keywords

adjustable dosing; asthma; Budesonide; fluticasone propionate; formoterol; salmeterol

Indexed keywords

BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE; FORMOTEROL; SALBUTAMOL; SALMETEROL;

ADOLESCENT; ADULT; ARTICLE; ASTHMA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE CONTROL; DISEASE SEVERITY; DRUG EFFICACY; DRUG TOLERABILITY; FEMALE; HUMAN; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL;

EID: 44649106957     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.03.019     Document Type: Article

References (18)

1. National Asthma Education and Prevention Program. Expert panel report 3: guidelines for the diagnosis and management of asthma-Full report (2007), National Institutes of Health, Bethesda (MD) NIH publication no. 08-4051
2. Bender B., Milgrom H., and Rand C. Nonadherence in asthmatic patients: is there a solution to the problem?. Ann Allergy Asthma Immunol 79 (1997) 177-186
3. Stoloff S.W., Stempel D.A., Meyer J., Stanford R.H., and Carranza Rosenzweig J.R. Improved refill persistence with fluticasone propionate and salmeterol in a single inhaler compared with other controller therapies. J Allergy Clin Immunol 113 (2004) 245-251
4. Aalbers R., Backer V., Kava T.T.K., Omenaas E.R., Sandström T., Jorup C., et al. Adjustable maintenance dosing with budesonide/formoterol compared with fixed-dose salmeterol fluticasone in moderate to severe asthma. Curr Med Res Opin 20 (2004) 225-240
5. Dahl R., Chuchalin A., Gor D., Yoxall S., and Sharma R. EXCEL: a randomized trial comparing salmeterol/fluticasone propionate and formoterol/budesonide combinations in adults with persistent asthma. Respir Med 100 (2006) 1152-1162
6. Brüggenjürgen B., Selim D., Kardos P., Richter K., Vogelmeier C., Roll S., et al. Economic assessment of adjustable maintenance treatment with budesonide/formoterol in a single inhaler versus fixed treatment in asthma. Pharmacoeconomics 23 (2005) 723-731
7. Ind P.W., Haughney J., Price D., Rosen J.-P., and Kennelly J. Adjustable and fixed dosing with budesonide/formoterol via a single inhaler in asthma patients: the ASSURE study. Respir Med 98 (2004) 464-475
8. FitzGerald J.M., Sears M.R., Boulet L.-P., Becker A.B., McIvor A.R., Ernst P., et al., Canadian Investigators. Adjustable maintenance dosing with budesonide/formoterol reduces asthma exacerbations compared with traditional fixed dosing: a five-month multicentre Canadian study. Can Respir J 10 (2003) 427-434
9. Ställberg B., Olsson P., Jorgenson L.A., Lindarck N., and Ekstrom T. Budesonide/formoterol adjustable maintenance dosing reduces asthma exacerbations versus fixed dosing. Int J Clin Pract 57 (2003) 656-661
10. Morice A.H., Hochmuth L., Edelund J., Thoren A., and Puterman A.S. Comparable long-term safety and efficacy of a novel budesonide/formoterol pressurized metered-dose inhaler versus budesonide/formoterol Turbuhaler in adolescents and adults with asthma. Pulm Pharmacol Ther 21 (2008) 32-39
11. American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 136 (1987) 225-244
12. Kuna P., Peters M.J., Manjra A.I., Jorup C., Naya I.P., Martínez-Jimenez N.E., et al. Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations. Int J Clin Pract 61 (2007) 725-736
13. FitzGerald J.M., Boulet L.-P., and Follows R.M.A. The CONCEPT trial: a 1-year, multicenter, randomized, double-blind, double-dummy comparison of a stable dosing regimen of salmeterol/fluticasone propionate with an adjustable maintenance dosing regimen of formoterol/budesonide in adults with persistent asthma. Clin Ther 27 (2005) 393-406
14. Symbicort product information. 31152-03. Revised October 2007. Available at: http://www.astrazeneca-us.com/pi/symbicort.pdf. Accessed January 17, 2008.
15. Advair Diskus product information. October 2007. Available at: http://us.gsk.com/products/assets/us_advair.pdf. Accessed January 17, 2008.
16. Leuppi J.D., Salzberg M., Meyer L., Bucher S.E., Nief M., Brutsche M.H., et al. An individualized, adjustable maintenance regimen of budesonide/formoterol provides effective asthma symptom control at a lower overall dose than fixed dosing. Swiss Med Wkly 133 (2003) 302-309
17. Buhl R., Kardos P., Richter K., Meyer-Sabellek W., Brüggenjürgen B., Willich S.N., et al. The effect of adjustable dosing with budesonide/formoterol on health-related quality of life and asthma control compared with fixed dosing. Curr Med Res Opin 20 (2004) 1209-1220
18. Berger W.E., Bleecker E.R., O'Dowd L., Miller C., and Mezzanotte W. Efficacy of once-daily budesonide (BUD) and formoterol (FM) administered via one pressurized metered-dose inhaler (pMDI) in asthma patients. [abstract]. Am J Respir Crit Care Med 175 (2007) A188