Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

Biochemical and Biophysical Research Communications

Volumn 426, Issue 1, 2012, Pages 100-105

  Zou, Ying ^a   Zhang, Ningzhe ^a   Ellerby, Lisa M ^a   Davalos, Albert R ^a   Zeng, Xianmin ^a   Campisi, Judith ^a   Desprez, Pierre Yves ^a,b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Astrocytes; Neuronal stem cells; Neurons; Senescence

Indexed keywords

NESTIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CARCINOGENICITY; CELL DEATH; CELL DIFFERENTIATION; CELL POPULATION; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; EMBRYONIC STEM CELL; FIBROBLAST; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; IONIZING RADIATION; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; WESTERN BLOTTING;

ASTROCYTES; BIOLOGICAL MARKERS; CELL AGING; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DNA DAMAGE; EMBRYONIC STEM CELLS; HUMANS; NEURAL STEM CELLS; NEURONS; RADIATION TOLERANCE;

EID: 84866340736     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.043     Document Type: Article

References (36)

1. Ying Q.L., Nichols J., Chambers I., Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003, 115:281-292.
2. Lerou P.H., Daley G.Q. Therapeutic potential of embryonic stem cells. Blood Rev. 2005, 19:321-331.
3. Swistowski A., Peng J., Han Y., Swistowska A.M., Rao M.S., Zeng X. Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. PLoS One 2009, 4:e6233.
4. Wahl G.M., Carr A.M. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat. Cell Biol. 2001, 3:277-286.
5. Parplys A.C., Petermann E., Petersen C., Dikomey E., Borgmann K. DNA damage by X-rays and their impact on replication processes. Radiother. Oncol. 2012, 102:466-471.
6. Valerie K., Yacoub A., Hagan M.P., Curiel D.T., Fisher P.B., Grant S., Dent P. Radiation-induced cell signaling: inside-out and outside-in. Mol. Cancer Ther. 2007, 6:789-801.
7. Finkel T., Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 2000, 408:239-247.
8. Klaunig J.E., Wang Z., Pu X., Zhou S. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol. Appl. Pharmacol. 2011, 254:86-99.
9. Edinger A.L., Thompson C.B. Death by design: apoptosis, necrosis and autophagy. Curr. Opin. Cell Biol. 2004, 16:663-669.
10. Campisi J., d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat. Rev. Mol. Cell Biol. 2007, 8:729-740.
11. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., Nelson P.S., Desprez P.Y., Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6:2853-2868.
12. Coppe J.P., Patil C.K., Rodier F., Krtolica A., Beausejour C., Parrinello S., Hodgson G., Chin K., Desprez P.Y., Campisi J. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One 2010, 5:e9188.
13. Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr. Opin. Genet. Dev. 2011, 21:107-112.
14. Rodier F., Campisi J. Four faces of cellular senescence. J. Cell Biol. 2011, 192:547-556.
15. Rodier F., Coppe J.P., Patil C.K., Hoeijmakers W.A., Munoz D.P., Raza S.R., Freund A., Campeau E., Davalos A.R., Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979.
16. Rodier F., Munoz D.P., Teachenor R., Chu V., Le O., Bhaumik D., Coppe J.P., Campeau E., Beausejour C., Kim S.H., Davalos A.R., Campisi J. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J. Cell Sci. 2011, 124:68-81.
17. Filion T.M., Qiao M., Ghule P.N., Mandeville M., van Wijnen A.J., Stein J.L., Lian J.B., Altieri D.C., Stein G.S. Survival responses of human embryonic stem cells to DNA damage. J. Cell Physiol. 2009, 220. 686-592.
18. Miura T., Mattson M.P., Rao M.S. Cellular lifespan and senescence signaling in embryonic stem cells. Aging Cell 2004, 3:333-343.
19. Qin H., Yu T., Qing T., Liu Y., Zhao Y., Cai J., Li J., Song Z., Qu X., Zhou P., Wu J., Ding M., Deng H. Regulation of apoptosis and differentiation by p53 in human embryonic stem cells. J. Biol. Chem. 2007, 282:5842-5852.
20. Zeng X., Rao M.S. Human embryonic stem cells: long term stability, absence of senescence and a potential cell source for neural replacement. Neuroscience 2007, 145:1348-1358.
21. Ezashi T., Das P., Roberts R.M. Low O2 tensions and the prevention of differentiation of hES cells. Proc. Natl. Acad. Sci. USA 2005, 102:4783-4788.
22. Mor G., Montagna M.K., Alvero A.B. Modulation of apoptosis to reverse chemoresistance. Methods Mol. Biol. 2008, 414:1-12.
23. Filion T.M., Qiao M., Ghule P.N., Mandeville M., van Wijnen A.J., Stein J.L., Lian J.B., Altieri D.C., Stein G.S. Survival responses of human embryonic stem cells to DNA damage. J. Cell Physiol. 2009, 220:586-592.
24. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O.M., Peacocke M., Campisi J. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 1995, 92:9363-9367.
25. Taupin P., Gage F.H. Adult neurogenesis and neural stem cells of the central nervous system in mammals. J. Neurosci. Res. 2002, 69:745-749.
26. Price J., Williams B.P. Neural stem cells. Curr. Opin. Neurobiol. 2001, 11:564-567.
27. Kennea N.L., Mehmet H. Neural stem cells. J. Pathol. 2002, 197:536-550.
28. Coppe J.P., Desprez P.Y., Krtolica A., Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 2010, 5:99-118.
29. Freund A., Orjalo A., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med. 2010, 16:238-248.
30. Orjalo A., Bhaumik D., Gengler B., Scott G.K., Campisi J. Cell surface IL-1α is an upstream regulator of the senescence-associated IL6/IL-8 cytokine network. Proc. Natl. Acad. Sci. USA 2009, 106:17031-17036.
31. Murry C.E., Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 2008, 132:661-680.
32. Maynard S., Swistowska A.M., Lee J.W., Liu Y., Liu S.T., Da Cruz A.B., Rao M., de Souza-Pinto N.C., Zeng X., Bohr V.A. Human embryonic stem cells have enhanced repair of multiple forms of DNA damage. Stem Cells 2008, 26:2266-2274.
33. Hong Y., Cervantes R.B., Tichy E., Tischfield J.A., Stambrook P.J. Protecting genomic integrity in somatic cells and embryonic stem cells. Mutat. Res. 2007, 614:48-55.
34. Saretzki G., Walter T., Atkinson S., Passos J.F., Bareth B., Keith W.N., Stewart R., Hoare S., Stojkovic M., Armstrong L., von Zglinicki T., Lako M. Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells. Stem Cells 2008, 26:455-464.
35. Acharya M.M., Lan M.L., Kan V.H., Patel N.H., Giedzinski E., Tseng B.P., Limoli C.L. Consequences of ionizing radiation-induced damage in human neural stem cells. Free Radic. Biol. Med. 2010, 49:1846-1855.
36. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathol. 2010, 119:7-35.