Consequences of ionizing radiation-induced damage in human neural stem cells

Free Radical Biology and Medicine

Volumn 49, Issue 12, 2010, Pages 1846-1855

  Acharya, Munjal M ^a   Lan, Mary L ^a   Kan, Vickie H ^a   Patel, Neal H ^a   Giedzinski, Erich ^a   Tseng, Bertrand P ^a   Limoli, Charles L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

DNA damage and repair; Free radicals; Human neural stem cells; Oxidative stress; Radiation

Indexed keywords

DNA; DOUBLE STRANDED DNA; GAMMA HISTONE H2AX; HISTONE H2AX; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL DAMAGE; CELL FRACTIONATION; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IONIZING RADIATION; IRRADIATION; NEURAL STEM CELL; NITROSATIVE STRESS; OXIDATIVE STRESS; PRIORITY JOURNAL;

APOPTOSIS; CELL CYCLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DNA DAMAGE; DNA REPAIR; GAMMA RAYS; HISTONES; HUMANS; NEURAL STEM CELLS; NITRIC OXIDE; OXIDATIVE STRESS; RADIATION INJURIES;

EID: 78650177391     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.08.021     Document Type: Article

References (29)

1. G.S. Bauman, L.E. Gaspar, B.J. Fisher, E.C. Halperin, D.R. Macdonald, and J.G. Cairncross A prospective study of short-course radiotherapy in poor prognosis glioblastoma multiforme Int. J. Radiat. Oncol. Biol. Phys. 29 1994 835 839
2. M.D. Walker, E. Alexander Jr., W.E. Hunt, C.S. MacCarty, M.S. Mahaley Jr., J. Mealey Jr., H.A. Norrell, G. Owens, J. Ransohoff, C.B. Wilson, E.A. Gehan, and T.A. Strike Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas: a cooperative clinical trial J. Neurosurg. 49 1978 333 343
3. J.M. Butler, S.R. Rapp, and E.G. Shaw Managing the cognitive effects of brain tumor radiation therapy Curr. Treat. Options Oncol. 7 2006 517 523
4. C.A. Meyers, and P.D. Brown Role and relevance of neurocognitive assessment in clinical trials of patients with CNS tumors J. Clin. Oncol. 24 2006 1305 1309
5. J. Raber, R. Rola, A. LeFevour, D. Morhardt, J. Curley, S. Mizumatsu, S.R. VandenBerg, and J.R. Fike Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis Radiat. Res. 162 2004 39 47 (Pubitemid 39044717)
6. 56Fe-particle irradiation in a dose-dependent manner Radiat. Res. 162 2004 442 446
7. G. Winocur, J.M. Wojtowicz, M. Sekeres, J.S. Snyder, and S. Wang Inhibition of neurogenesis interferes with hippocampus-dependent memory function Hippocampus 16 2006 296 304
8. D.D. Roman, and P.W. Sperduto Neuropsychological effects of cranial radiation: current knowledge and future directions Int. J. Radiat. Oncol. Biol. Phys. 31 1995 983 998
9. P.S. Eriksson, E. Perfilieva, T. Bjork-Eriksson, A.M. Alborn, C. Nordborg, D.A. Peterson, and F.H. Gage Neurogenesis in the adult human hippocampus Nat. Med. 4 1998 1313 1317
10. F.H. Gage Mammalian neural stem cells Science 287 2000 1433 1438
11. H.A. Cameron, C.S. Woolley, B.S. McEwen, and E. Gould Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat Neuroscience 56 1993 337 344 (Pubitemid 23274753)
12. C. Lois, and A. Alvarez-Buylla Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia Proc. Natl Acad. Sci. USA 90 1993 2074 2077
13. M.B. Luskin Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone Neuron 11 1993 173 189
14. E.A. Markakis, and F.H. Gage Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles J. Comp. Neurol. 406 1999 449 460
15. J.R. Fike, R. Rola, and C.L. Limoli Radiation response of neural precursor cells Neurosurg. Clin. North Am. 18 2007 115 127
16. J.R. Fike, S. Rosi, and C.L. Limoli Neural precursor cells and central nervous system radiation sensitivity Semin. Radiat. Oncol. 19 2009 122 132
17. S. Mizumatsu, M. Monje, D. Morhardt, R. Rola, T. Palmer, and J. Fike Extreme sensitivity of adult neurogenesis to low doses of X-irradiation Cancer Res. 63 2003 4021 4027
18. M.L. Monje, S. Mizumatsu, J.R. Fike, and T.D. Palmer Irradiation induces neural precursor-cell dysfunction Nat. Med. 8 2002 955 962
19. L. Vallieres, I.L. Campbell, F.H. Gage, and P.E. Sawchenko Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6 J. Neurosci. 22 2002 486 492
20. E. Gould, and P. Tanapat Stress and hippocampal neurogenesis Biol. Psychiatry 46 1999 1472 1479
21. C. Limoli, E. Giedzinski, R. Rola, S. Otsuka, T. Palmer, and J. Fike Radiation response of neural precursor cells: linking cellular sensitivity to cell cycle checkpoints, apoptosis and oxidative stress Radiat. Res. 161 2004 17 27
22. S.A. Amundson, M. Bittner, P. Meltzer, J. Trent, and A.J. Fornace Jr. Induction of gene expression as a monitor of exposure to ionizing radiation Radiat. Res. 156 2001 657 661
23. L. Cartee, J.A. Vrana, Z. Wang, J.S. Park, M. Birrer, P.B. Fisher, S. Grant, and P. Dent Inhibition of the mitogen activated protein kinase pathway potentiates radiation-induced cell killing via cell cycle arrest at the G2/M transition and independently of increased signaling by the JNK/c-Jun pathway Int. J. Oncol. 16 2000 413 422
24. P. Dent, A. Yacoub, J. Contessa, R. Caron, G. Amorino, K. Valerie, M.P. Hagan, S. Grant, and R. Schmidt-Ullrich Stress and radiation-induced activation of multiple intracellular signaling pathways Radiat. Res. 159 2003 283 300
25. J. Kim, and P.K. Wong Loss of ATM impairs proliferation of neural stem cells through oxidative stress-mediated p38 MAPK signaling Stem Cells 27 2009 1987 1998
26. J. Smith, E. Ladi, M. Mayer-Proschel, and M. Noble Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell Proc. Natl Acad. Sci. USA 97 2000 10032 10037
27. K. Fishman, J. Baure, Y. Zou, T.T. Huang, M. Andres-Mach, R. Rola, T. Suarez, M. Acharya, C.L. Limoli, K.R. Lamborn, and J.R. Fike Radiation-induced reductions in neurogenesis are ameliorated in mice deficient in CuZnSOD or MnSOD Free Radic. Biol. Med. 47 2009 1459 1467
28. E. Tada, J.M. Parent, D.H. Lowenstein, and J.R. Fike X-irradiation causes a prolonged reduction in cell proliferation in the dentate gyrus of adult rats Neuroscience 99 2000 33 41
29. V.J Caiozzo, E. Giedzinski, M. Baker, T. Suarez, A. Izadi, M. Lan, J. Cho-Lim, B.P Tseng, and C.L. Limoli The radiosensitivity of satellite cells: Cell cycle regulation, apoptosis and oxidative stress Radiat. Res. 174 2010 582 589