Abnormal functional motor lateralization in healthy siblings of patients with schizophrenia

Psychiatry Research - Neuroimaging

Volumn 203, Issue 1, 2012, Pages 54-60

  Altamura, Mario ^a   Fazio, Leonardo ^b,c   De Salvia, Michela ^a   Petito, Annamaria ^a   Blasi, Giuseppe ^b,c   Taurisano, Paolo ^b,c   Romano, Raffaella ^b,c   Gelao, Barbara ^b,c   Bellomo, Antonello ^a   Bertolino, Alessandro ^b,c  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

Author keywords

FMRI; Functional lateralization; Genetic risk; Intermediate phenotype; Motor activity

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC ASSOCIATION; GENETIC RISK; HANDEDNESS; HEMISPHERIC DOMINANCE; HUMAN; IMAGE PROCESSING; MALE; MOTOR ACTIVITY; MOTOR LATERALIZATION; MOTOR PERFORMANCE; PHENOTYPE; PREMOTOR CORTEX; PRIORITY JOURNAL; PSYCHOMOTOR PERFORMANCE; SCHIZOPHRENIA; SIBLING; TASK PERFORMANCE;

ADULT; CASE-CONTROL STUDIES; CEREBRAL CORTEX; FEMALE; FUNCTIONAL LATERALITY; FUNCTIONAL NEUROIMAGING; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MOTOR ACTIVITY; MOTOR CORTEX; PARIETAL LOBE; PSYCHOMOTOR PERFORMANCE; REACTION TIME; SCHIZOPHRENIA; SIBLINGS;

EID: 84866305321     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2012.02.008     Document Type: Article

References (65)

1. Bartley A.J., Jones D.W., Weinberger D.R. Genetic variability of human brain size and cortical gyral patterns. Brain 1997, 120:257-269.
2. Bertolino A., Blasi G. The genetics of schizophrenia. Neuroscience 2009, 164:288-299.
3. Bertolino A., Blasi G., Caforio G., Latorre V., De Candia M.P., Rubino V., Callicott J.H., Mattay V.S., Bellomo A., Scarabino T., Weinberger D.R., Nardini M. Functional lateralization of the sensorimotor cortex in patients with schizophrenia: effects of treatment with olanzapine. Biological Psychiatry 2004, 56:190-197.
4. Bertolino A., Caforio G., Blasi G., De Candia M., Latorre V., Petruzzella V., Altamura M., Nappi G., Papa S., Callicott J.H., Mattay V.S., Bellomo A., Scarabino T., Weinberger D.R., Nardini M. Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia. The American Journal of Psychiatry 2004, 161:1798-1805.
5. 158 met genotype on attentional control. The Journal of Neuroscience 2005, 25:5038-5045.
6. Blasi G., Goldberg T.E., Elvevåg B., Rasetti R., Bertolino A., Cohen J., Alice G., Zoltick B., Weinberger D.R., Mattay V.S. Differentiating allocation of resources and conflict detection within attentional control processing. The European Journal of Neuroscience 2007, 25:594-602.
7. Braus D.F., Ende G., Weber-Fahr W., Sartorius A., Krier A., Hubrich-Ungureanu P. Antypsychotic drug effects on motor activation measured by functional magnetic resonance imaging in schizophrenic patients. Schizophrenia Research 1999, 39:19-29.
8. Braus D.F., Ende G., Hubrich-Ungureanu P., Henn F.A. Cortical response to motor stimulation in neuroleptic naïve first episode schizophrenics. Psychiatry Research: Neuroimaging 2000, 98:145-154.
9. Callicott J.H., Bertolino A., Mattay V.S., Langheim F.J.P., Duyn J., Coppola R., Goldberg T.E., Weinberger D.R. Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited. Cerebral Cortex 2000, 10:1078-1092.
10. Callicott J.H., Egan M.F., Mattay V.S., Bertolino A., Bone A.D., Verchinski B., Weinberger D.R. Abnormal response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia. The American Journal of Psychiatry 2003, 160:709-719.
11. Cardno A.G., Gottesman I.I. Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. American Journal of Medical Genetics 2000, 97:12-17.
12. Crow T.J. Is schizophrenia the price that Homo sapiens pays for language?. Schizophrenia Research 1997, 28:127-141.
13. Dassonville P., Zhu X.H., Uurbil K., Kim S.G., Ashe J. Functional activation in motor cortex reflects the direction and the degree of handedness. Proceedings of the National Academy of Sciences of the United States of America 1997, 94. 14015-10418.
14. Deep-Soboslay A., Hyde T.M., Callicott J.H., Lener M.S., Verchinski B.A., Apud I.A., Weinberger D.R., Elvevåg B. Handedness, heritability, neurocognition and brain asymmetry in schizophrenia. Brain 2010, 133:3113-3122.
15. Fazio L., Blasi G., Taurisano P., Papazacharias A., Romano R., Gelao B., Ursini G., Quarto T., Lo Bianco L., Di Giorgio A., Mancini M., Popolizio T., Rubini G., Bertolino A. D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans. NeuroImage 2010, 54:2915-2921.
16. Fazzari P., Paternian A.V., Valiente M., Pla R., Lujan R., Lloyd K., Lema J., Marin O., Rico B. Control of cortical GABA circuitry development by Nrg1 and ErbB4 signaling. Nature 2010, 464:1376-1380.
17. Fernandez G., Weis S., Stoffel-Wagner B., Tendolkar I., Reuber M., Beyenburg S., Klaver P., Fell J., de Greiff A., Ruhlmann J., Reul J., Elger C.E. Menstrual cycle-dependent neural plasticity in the adult human brain is hormone, task, and region specific. The Journal of Neuroscience 2003, 23:3790-3795.
18. First M.B., Gibbon M., Spitzer R., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorder 1997, American Psychiatry Publishing, Inc., Arlington.
19. First M.B., Gibbon M., Spitzer R. Structured Clinical Interview for DSM-IV, Axis II Personality Disorder 1997, American Psychiatric Publishing, Inc.
20. Flyckt L., Sydow O., Bjerkensted L., Edman G., Rydin E., Wiesel F.A. Neurological signs and psychomotor performance in patients with schizophrenia, their relatives and healthy controls. Psychiatry Research 1999, 86:113-129.
21. Friston K.J., Holmes A.P., Worsley K.J., Poline J.B., Frith C.D., Frackowiak R.S.J. Statistical parametric mapping in functional imaging: a general approach. Human Brain Mapping 1995, 2:189-210.
22. Fusar-Poli P., Perez J., Broome M., Borgwardt S., Placentino A., Caverzasi E., Cortesi M., Veggiotti P., Politi P., Barale F., McGuire P. Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 2007, 31:465-484.
23. Gazzaniga M.S. Cerebral specialization and interhemispheric communication: does the corpus callosum enable th human condition?. Brain 2000, 123:1293-1326.
24. Genovese C.R., Lazar N.A., Nichols T. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage 2002, 15:870-878.
25. Gonzales-Hernandez J.A., Pita-Alcorta C., Cedeno I., Dias-Comas L., Figuereo-Rodriguez P. Abnormal functional asymmetry in occipital areas may prevent frontotemporal regions from achieving functional lateralità during the WCST performance in patients with schizophrenia. Schizophrenia Research 2003, 61:229-233.
26. Gottesman I.I., Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. The American Journal of Psychiatry 2003, 160:636-645.
27. Grubbs F. Procedures for detecting outlying observations in samples. Technometrics 1969, 11:1-21.
28. Gruzelier J.H. Functional neuropsychological asymmetry in schizophrenia: a review and reorientation. Schizophrenia Bulletin 1999, 25:91-120.
29. Günther W., Petsch R., Steinberg R., Moser E., Streck P., Heller H., Kurtz G., Hippius H. Brain dysfunction during motor activation and corpus callosum alterations in schizophrenia measures by cerebral blood flow and magnetic resonance imaging. Biological Psychiatry 1991, 29:535-555.
30. Gut M., Urbanik A., Forsberg L., Binder M., Rymarczyk K., Sobiecka B., Kozub J., Grabowska A. Brain correlates of right-handedness. Acta Neurobiologiae Experimentalis 2007, 67:43-51.
31. Harrison P.J. The neuropathology of schizophrenia: a critical review of the data and their interpretation. Brain 1999, 122:593-624.
32. Harrison P.J., Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Molecular Psychiatry 2005, 10:40-68.
33. Hollingshead A.A. Four-factor index of social status 1975, Yale University, New Haven, CT.
34. Hopfinger J.B., Büchel C., Holmes A.P., Friston K.J. A study of analysis parameters that influence the sensitivity of event-related fMRI analyses. NeuroImage 2000, 11:326-333.
35. Ismail B., Cantor-Graae E., McNeil T.E. Neurological abnormalities in schizophrenic patients and their siblings. The American Journal of Psychiatry 1998, 155:84-89.
36. James J.W. Frequency in relatives for an all-or-none trait. Annals of Human Genetics 1971, 35:47-49.
37. Kavashima R., Yamada K., Kinomura S., Yamaguchi T., Matsui H., Yoshioka S., Fukuda H. Regional cerebral blood flow changes of cortical motor areas and prefrontal areas in humans related to ipsilateral and contralateral hand movement. Brain Research 1993, 623:33-40.
38. Klar J.S.A. Genetic models for handedness, brain lateralization, schizophrenia, and manic-depression. Schizophrenia Research 1999, 39:207-218.
39. Maldjian J.A., Laurienti P.J., Kraft R.A., Burdette J.H. An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data set. NeuroImage 2003, 19:1233-1239.
40. Manoach D.S., Press D.Z., Thangaraj J., Searl M.M., Goff D.C., Halpern E., Saper C.B., Warach S. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biological Psychiatry 1999, 45:1128-1137.
41. Manoach D.S., Gollub R.L., Benson E.S., Searl M.M., Goff D.C., Halpern E., Saper C.B., Rauch S.L. Schizophrenic patients show aberrant activation of the dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biological Psychiatry 2000, 48:99-109.
42. Marconi B., Genovesio A., Giannetti S., Molinari M., Caminiti R. Callosal connections of dorso-lateral premotor cortex. The European Journal of Neuroscience 2003, 18:775-788.
43. Mattay V.S., Weinberger D.R. Organization of the human motor system as studied by functional magnetic resonance imaging. European Journal of Radiology 1999, 30:105-114.
44. Mattay V.S., Callicott J.H., Bertolino A., Santha A.K., Tallent K.A., Goldberg T.E., Frank J.A., Weinberger D.R. Abnormal functional lateralization of the sensorimotor cortex in patients with schizophrenia. Neuroreport 1997, 8:2977-2984.
45. Meyer-Lindenberg A., Weinberger D.R. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews. Neuroscience 2006, 7:818-827.
46. Mochizuki H., Huang Y., Rothwell J.C. Interhemispheric interaction between human dorsal premotor and contralateral primary motor cortex. The Journal of Physiology 2004, 561:331-338.
47. Müller J.L., Röder C.H., Schuierer G., Klein H.E. Subcortical overactivation in untreated schizophrenic patients: a functional magnetic resonance image finger-tapping study. Psychiatry and Clinical Neurosciences 2002, 56:77-84.
48. Müller J.L., Röder C.H., Schuierer G., Klein H.E. Motor-induced brain activation in cortical, subcortical and cerebellar regions in schizophrenic inpatients. A whole brain fMRI fingertapping study. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2002, 26:421-426.
49. Müller J.L., Deuticke C., Putzhammer A., Röder C.H., Hajak G., Winkler J. Schizophrenia and Parkinson's disease lead to equal motor-related changes in cortical and subcortical brain activation: a fingertapping study. Psychiatry and Clinical Neurosciences 2003, 57:562-568.
50. Murray R.M., Lewis S.W. Is schizophrenia a neurodevelopmental disorder?. British Medical Journal 1987, 295:681-682.
51. Netz J., Ziemann U., Homberg V. Hemispheric asymmetry of transacallosal inhibition in man. Experimental Brain Research 1995, 104:527-533.
52. Northoff G., Braus D.F., Sartorius A., Khoram-Sefat D., Russ M., Eckert J., Herrig M., Leschinger A., Bogerts B., Henn F.A. Reduced activation and altered laterality in two neuroleptic-naïve catatonic patients during a motor task in functional MRI. Psychological Medicine 1999, 29:997-1002.
53. O'Donovan M.C., Williams N.M., Owen M.J. Recent advances in the genetics of schizophrenia. Human Molecular Genetics 2003, 12:125-133.
54. Oertel V., Knöchel A., Rotarska-Jagiela A., Schönmeyer R., Lindner M., van de Ven V., Haenschel C., Uhlhaas P., Maurer K., Linden D.E.J. Reduced laterality as a trait marker of schizophrenia-evidence from structural and functional neuroimaging. The Journal of Neuroscience 2010, 30:2289-2299.
55. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971, 9:97-113.
56. Payoux P., Boulanouar K., Sarramon C., Fabre N., Descombes S., Galitsky M., Thalamas C., Brefel-Courbon C., Sabatini U., Manelfe C., Chollet F., Schmitt L., Rascol O. Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study. Movement Disorders 2004, 19:83-90.
57. Rico B., Marin O. Neuregulin signaling, cortical circuitry development and schizophrenia. Current Opinion in Genetics & Development 2011, 21:262-270.
58. Risch N. Linkage strategies for genetically complex traits. The power of affected relative pairs. American Journal of Human Genetics 1990, 46:229-241.
59. Singh L.N., Higano S., Takahashi S., Abe Y., Sakamoto M., Kurihara N., Furuta S., Tamura H., Yanagawa I., Fujii T., Ishibashi T., Marouka S., Yamada S. Functional MR imaging of cortical activation of the cerebral hemispheres during motor tasks. AJNR. American Journal of Neuroradiology 1998, 19:275-280.
60. Sommer I.E., Ramsey N.F., Mandl R.C., Kahn R.S. Language lateralization in female patients with schizophrenia: an fMRI study. Schizophrenia Research 2003, 60:183-190.
61. Talairach J., Tournoux P. Co-planar stereotaxic atlas of the human brain 1998, Thiem, New York.
62. Tanji J., Okano K., Sato C.K. Neuronal activity in cortical motor areas related to ipsilateral, contralateral, and bilateral digit movements of the monkey. Journal of Neurophysiology 1988, 60:325-343.
63. Weinberger D.R. Implication of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 1987, 44:660-669.
64. Witt S.T., Meyerand E., Laird A.R. Functional neuroimaging correlates of finger tapping task variations: an ALE meta-analysis. NeuroImage 2008, 48:343-356.
65. Woodward N.D., Waldie B., Rogers B., Tibbo., Purdon S.E. Abnormal prefrontal activity and connectivity during response selection in first episode psychosis, chronic schizophrenia and unaffected siblings of individuals with schizophrenia. Schizophrenia Research 2009, 60:183-190.