Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses

Journal of Biological Chemistry

Volumn 283, Issue 22, 2008, Pages 15479-15490

  Schiefelbein, Dana ^a   Goren, Itamar ^a   Fisslthaler, Beate ^a   Schmidt, Helmut ^a   Geisslinger, Gerd ^a   Pfeilschifter, Josef ^a   Frank, Stefan ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; ENDOTHELIAL CELLS; GROWTH (MATERIALS); INSULIN; LAWS AND LEGISLATION; MAINTENANCE; PEPTIDES; SKIN;

BINDING PROTEIN 1; BINDING PROTEINS; BIPHASIC; ELEVATED LEVELS; ENZYMATIC ACTIVITIES; EPIDERMAL GROWTH FACTORS; EUKARYOTIC INITIATION FACTORS; FUNCTIONAL ROLES; IN VITRO EXPERIMENTS; IN-SITU; INHIBITORY EFFECTS; KERATINOCYTE; KERATINOCYTES; MEVALONATE; POTENTIAL FUNCTIONS; PROTEIN EXPRESSIONS; PROTEIN RELEASES; SIMVASTATIN; SKIN INJURIES; STEROL REGULATORY ELEMENTS; TRANSFORMING GROWTH FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTORS;

HORMONES;

EPIDERMAL GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN; MEVALONIC ACID; SIMVASTATIN; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN; CARRIER PROTEIN; EIF4EBP1 PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PHOSPHOPROTEIN; SREBF2 PROTEIN, MOUSE; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RNA TRANSLATION; SKIN INJURY; WOUND HEALING; ANIMAL; BIOSYNTHESIS; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; INJURY; MALE; METABOLISM; PHYSIOLOGY; SKIN; TIME;

EUKARYOTA; MUS;

ANIMALS; CARRIER PROTEINS; CELL PROLIFERATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSULIN; KERATINOCYTES; MALE; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOPROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; SIMVASTATIN; SKIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TIME FACTORS; TRANSFORMING GROWTH FACTOR ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

EID: 47249133453     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709841200     Document Type: Article

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