The hydroxy-methyl-glutaryl CoA reductase promoter polymorphism is associated with Alzheimer's risk and cognitive deterioration

Neuroscience Letters

Volumn 416, Issue 1, 2007, Pages 66-70

  Porcellini, Elisa ^a   Calabrese, Elena ^b   Guerini, Franca ^b   Govoni, Marzia ^a   Chiappelli, Martina ^a   Tumini, Emanuela ^a   Morgan, Kevin ^c   Chappell, Sally ^c   Kalsheker, Noor ^c   Franceschi, Massimo ^d   Licastro, Federico ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^d Neurology Department   (Italy)

Author keywords

AD risk; Alzheimer's disease; Cholesterol; Cognitive decline; HMGCR; Polymorphism; Transfection

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LUCIFERASE;

AGED; ALZHEIMER DISEASE; ARTICLE; ASSAY; CHOLESTEROL METABOLISM; COGNITION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE COURSE; ENZYME POLYMORPHISM; FOLLOW UP; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; GENOTYPE; HUMAN; HUMAN CELL; ITALY; MAJOR CLINICAL STUDY; MENTAL DETERIORATION; MENTAL PERFORMANCE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASTROCYTES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHOLESTEROL; COGNITION DISORDERS; DISEASE PROGRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDROXYMETHYLGLUTARYL COA REDUCTASES; LIVER NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK FACTORS; TRANSFECTION;

EID: 33947328570     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.01.046     Document Type: Article

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