Dietary supplementation with lacto-wolfberry enhances the immune response and reduces pathogenesis to influenza infection in mice

Journal of Nutrition

Volumn 142, Issue 8, 2012, Pages 1596-1602

  Ren, Zhihong ^a,b   Na, Lixin ^a,c   Xu, Yanmei ^a,b   Rozati, Mitra ^a   Wang, Junpeng ^a   Xu, Jianguo ^b   Sun, Changhao ^c   Vidal, Karine ^d   Wu, Dayong ^a   Meydani, Simin Nikbin ^a  

^a TUFTS UNIVERSITY   (United States)

^b National Institute for Communicable Disease Control and Prevention   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d NESTLÉ RESEARCH CENTER   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 2; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INFLUENZA A (H1N1); LACTO WOLFBERRY; LUNG; LUNG INFECTION; LYCIUM; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PATHOGENESIS; PHENOTYPE; T LYMPHOCYTE; WEIGHT REDUCTION;

ANIMAL FEED; ANIMALS; DIET; DIETARY SUPPLEMENTS; GLUTATHIONE; GLUTATHIONE DISULFIDE; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; KILLER CELLS, NATURAL; LUNG; LYCIUM; LYMPHOCYTES; MALE; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; RANDOM ALLOCATION; SPLEEN;

MUS;

EID: 84866287799     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.112.159467     Document Type: Article

References (52)

1. WHO. Influenza. WHO fact sheet N° 211. WHO Media Center, Geneva, 2003. Available from: http://www.who.int/mediacentre/factsheets/2003/fs211/en/.
2. Lesourd BM. Nutrition and immunity in the elderly: modification of immune responses with nutritional treatments. Am J Clin Nutr. 1997; 66:478S-84S.
3. Bogden JD, Louria DB. Aging and the immune system: the role of micronutrient nutrition. Nutrition. 1999;15:593-5.
4. High KP. Nutritional strategies to boost immunity and prevent infection in elderly individuals. Clin Infect Dis. 2001;33:1892-900.
5. Ahluwalia N. Aging, nutrition and immune function. J Nutr Health Aging. 2004;8:2-6.
6. Meydani SN, Meydani M, Blumberg JB, Leka LS, Siber G, Loszewski R, Thompson C, Pedrosa MC, Diamond RD, Stollar BD. Vitamin E supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial. JAMA. 1997;277:1380-6.
7. Bucheli P, Gao Q, Redgwell R, Vidal K, Wang J, ZhangW. Biomolecular and clinical aspects of Chinese wolfberry. In: Benzie IFF, Wachtel-Galor S, editors. Herbal medicine: biomolecular and clinical aspects, 2nd edition. Boca Raton (FL): CRC Press; 2011. Chapter 14.
8. Luo Q, Li Z, Yan J, Zhu F, Xu RJ, Cai YZ. Lycium barbarum polysaccharides induce apoptosis in human prostate cancer cells and inhibits prostate cancer growth in a xenograft mouse model of human prostate cancer. J Med Food. 2009;12:695-703.
9. Gan L, Zhang SH, Liu Q, Xu HB. A polysaccharide-protein complex from Lycium barbarum upregulates cytokine expression in human peripheral blood mononuclear cells. Eur J Pharmacol. 2003;471:217-22.
10. Potterat O. Goji (Lycium barbarum and L. chinense): phytochemistry, pharmacology and safety in the perspective of traditional uses and recent popularity. Planta Med. 2010;76:7-19.
11. Li XM, Ma YL, Liu XJ. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J Ethnopharmacol. 2007; 111:504-11.
12. Chang RC, So KF. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases: what do we know so far? Cell Mol Neurobiol. 2008;28:643-52.
13. Zhou L, Leung I, Tso MO, Lam KW. The identification of dipalmityl zeaxanthin as the major carotenoid in Gou Qi Zi by high pressure liquid chromatography and mass spectrometry. J Ocul Pharmacol Ther. 1999; 15:557-65.
14. Li SY, Yang D, Yeung CM, Yu WY, Chang RC, So KF, Wong D, Lo AC. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS ONE. 2011;6:e16380.
15. Kim HW, Chew BP, Wong TS, Park JS, Weng BB, Byrne KM, Hayek MG, Reinhart GA. Modulation of humoral and cell-mediated immune responses by dietary lutein in cats. Vet Immunol Immunopathol. 2000; 73:331-41.
16. Roberts RL, Green J, Lewis B. Lutein and zeaxanthin in eye and skin health. Clin Dermatol. 2009;27:195-201.
17. Nakajima Y, Shimazawa M, Otsubo K, Ishibashi T, Hara H. Zeaxanthin, a retinal carotenoid, protects retinal cells against oxidative stress. Curr Eye Res. 2009;34:311-8.
18. Benzie IF, Chung WY, Wang J, Richelle M, Bucheli P. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). Br J Nutr. 2006;96:154-60.
19. Vidal K, Benyacoub J, Sanchez-Garcia J, Foata F, Segura-Roggero I, Serrant P, Moser M, Blum S. Intake of a milk-based wolfberry formulation enhances the immune response of young-adult and aged mice. Rejuvenation Res. 2010;13:47-53.
20. Amagase H, Sun B, Nance DM. Immunomodulatory effects of a standardized Lycium barbarum fruit juice in Chinese older healthy human subjects. J Med Food. 2009;12:1159-65.
21. Vidal K, Bucheli P, Moulin J, Shen L, Zhang C, Wang J, Blum S, Benyacoub J. Effect of dietary supplementation with a milk-based wolfberry preparation on the immune response to influenza vaccine in elderly. Rejuvenation Res. In press 2012.
22. Reeves PG, Nielsen FH, Fahey GC Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
23. Beck MA, Nelson HK, Shi Q, Van Dael P, Schiffrin EJ, Blum S, Barclay D, Levander OA. Selenium deficiency increases the pathology of an influenza virus infection. FASEB J. 2001;15:1481-3.
24. Ren Z, Pae M, Dao MC, Smith D, Meydani SN, Wu D. Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr. 2010;140:1335-41.
25. Han SN, Wu D, Ha WK, Beharka A, Smith DE, Bender BS, Meydani SN. Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus. Immunology. 2000;100:487-93.
26. Reed LJ, Muench H. A simple method of estimating fifty percent endpoints. Am J Hyg. 1938;27:4.
27. Wu D, Pae M, Ren Z, Guo Z, Smith D, Meydani SN. Dietary supplementation with white button mushroom enhances natural killer cell activity in C57BL/6 mice. J Nutr. 2007;137:1472-7.
28. Harvey PR, Ilson RG, Strasberg SM. The simultaneous determination of oxidized and reduced glutathiones in liver tissue by ion pairing reverse phase high performance liquid chromatography with a coulometric electrochemical detector. Clin Chim Acta. 1989;180:203-12.
29. Amagase H, Nance DM. A randomized, double-blind, placebo-controlled, clinical study of the general effects of a standardized Lycium barbarum (Goji) Juice, GoChi. J Altern Complement Med. 2008;14:403-12.
30. Zhu J, Zhao LH, Zhao XP, Chen Z. Lycium barbarum polysaccharides regulate phenotypic and functional maturation of murine dendritic cells. Cell Biol Int. 2007;31:615-9.
31. Chen Z, Lu J, Srinivasan N, Tan BK, Chan SH. Polysaccharide-protein complex from Lycium barbarum L. is a novel stimulus of dendritic cell immunogenicity. J Immunol. 2009;182:3503-9.
32. Toapanta FR, Ross TM. Impaired immune responses in the lungs of aged mice following influenza infection. Respir Res. 2009;10:112.
33. Ronni T, Matikainen S, Sareneva T, Melen K, Pirhonen J, Keskinen P, Julkunen I. Regulation of IFN-alpha/beta, MxA, 2',5'-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells. J Immunol. 1997;158:2363-74.
34. García-Sastre A, Durbin RK, Zheng H, Palese P, Gertner R, Levy DE, Durbin JE. The role of interferon in influenza virus tissue tropism. J Virol. 1998;72:8550-8.
35. Brydon EW, Morris SJ, Sweet C. Role of apoptosis and cytokines in influenza virus morbidity. FEMS Microbiol Rev. 2005;29:837-50.
36. García-Sastre A. Mechanisms of inhibition of the host interferon alpha/beta-mediated antiviral responses by viruses. Microbes Infect. 2002;4:647-55.
37. Meager A. Cytokine regulation of cellular adhesion molecule expression in inflammation. Cytokine Growth Factor Rev. 1999;10:27-39.
38. Schmitz N, Kurrer M, Bachmann MF, Kopf M. Interleukin-1 is responsible for acute lung immunopathology but increases survival of respiratory influenza virus infection. J Virol. 2005;79:6441-8.
39. Sprenger H, Meyer RG, Kaufmann A, Bussfeld D, Rischkowsky E, Gemsa D. Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection. J Exp Med. 1996;184: 1191-6.
40. Joseph SB, Miner KT, Croft M. Augmentation of naive, Th1 and Th2 effector CD4 responses by IL-6, IL-1 and TNF. Eur J Immunol. 1998; 28:277-89.
41. Julkunen I, Melen K, Nyqvist M, Pirhonen J, Sareneva T, Matikainen S. Inflammatory responses in influenza A virus infection. Vaccine. 2000;19: Suppl 1:S32-7.
42. Stark GR, Kerr IM, Williams BR, Silverman RH, Schreiber RD. How cells respond to interferons. Annu Rev Biochem. 1998;67:227-64.
43. Hussell T, Pennycook A, Openshaw PJ. Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology. Eur J Immunol. 2001;31:2566-73.
44. Conn CA, McClellan JL, Maassab HF, Smitka CW, Majde JA, Kluger MJ. Cytokines and the acute phase response to influenza virus in mice. Am J Physiol. 1995;268:R78-84.
45. Hennet T, Ziltener HJ, Frei K, Peterhans E. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. J Immunol. 1992;149:932-9.
46. Han SN, Meydani M, Wu D, Bender BS, Smith DE, Vina J, Cao G, Prior RL, Meydani SN. Effect of long-term dietary antioxidant supplementation on influenza virus infection. J Gerontol A Biol Sci Med Sci. 2000;55:B496-503.
47. Scherle PA, Palladino G, Gerhard W. Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells. J Immunol. 1992;148:212-7.
48. Tamura S, Miyata K, Matsuo K, Asanuma H, Takahashi H, Nakajima K, Suzuki Y, Aizawa C, Kurata T. Acceleration of influenza virus clearance by Th1 cells in the nasal site of mice immunized intranasally with adjuvant-combined recombinant nucleoprotein. J Immunol. 1996;156:3892-900.
49. Hennet T, Peterhans E, Stocker R. Alterations in antioxidant defences in lung and liver of mice infected with influenza A virus. J Gen Virol. 1992;73:39-46.
50. Bucheli P, Vidal K, Shen L, Gu Z, Zhang C, Miller LE, Wang J. Goji berry effects on macular characteristics and plasma antioxidant levels. Optom Vis Sci. 2011;88:257-62.
51. Lambert JD, Lee MJ, Diamond L, Ju J, Hong J, Bose M, Newmark HL, Yang CS. Dose-dependent levels of epigallocatechin-3-gallate in human colon cancer cells and mouse plasma and tissues. Drug Metab Dispos. 2006;34:8-11.
52. Schneider K, Oltmanns J, Hassauer M. Allometric principles for interspecies extrapolation in toxicological risk assessment-empirical investigations. Regul Toxicol Pharmacol. 2004;39:334-47.