Polysaccharide-protein complex from Lycium barbarum L. is a novel stimulus of dendritic cell immunogenicity

Journal of Immunology

Volumn 182, Issue 6, 2009, Pages 3503-3509

  Chen, Zhisong ^a   Lu, Jinhua ^a   Srinivasan, Nalini ^a   Tan, Benny Kwong Huat ^a   Chan, Soh Ha ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD86 ANTIGEN; INTERLEUKIN 12P40; INTERLEUKIN 12P70; LYCIUM BARBARUM EXTRACT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POLYSACCHARIDE; HERBACEOUS AGENT; INTERLEUKIN 12; LYCIUM BARBARUM POLYSACCHARIDE; VEGETABLE PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FEMALE; HOST; IMMUNITY; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; MEDICINAL PLANT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; CYTOLOGY; IMMUNOLOGY; ISOLATION AND PURIFICATION; LYCIUM; METABOLISM;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DRUGS, CHINESE HERBAL; FEMALE; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; LYCIUM; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLANT PROTEINS; TH1 CELLS; TH2 CELLS;

EID: 65449134760     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0802567     Document Type: Article

References (35)

1. Gan, L., S. H. Zhang, Q. Liu, and H. B. Xu. 2003. A polysaccharide- protein complex from Lycium barbarum up-regulates cytokine expression in human peripheral blood mononuclear cells. Eur. J. Pharmacol. 471: 217-222.
2. Gan, L., S. H. Zhang, X. L. Yang, and H. B. Xu. 2004. Immunomodulation and antitumor activity by a polysaccharide-protein complex from Lycium barbarum. Int. Immunopharmacol. 4: 563-569.
3. Peng, X. M., and G. Y. Tian. 2001. Structural characterization of the glycan part of glycoconjugate LbGp2 from Lycium barbarum L. Carbohydr. Res. 331: 95-99.
4. Qin, X., R. Yamauchi, K. Aizawa, T. Inakuma, and K. Kato. 2001. Structural features of arabinogalactan-proteins from the fruit of Lycium chinense Mill. Carbohydr. Res. 333: 79-85.
5. Tzianabos, A. O. 2000. Polysaccharide immunomodulators as therapeutic agents: structural aspects and biologic function. Clin. Microbiol. Rev. 13: 523-533.
6. Du, G., L. Liu, and J. Fang. 2004. Experimental study on the enhancement of murine splenic lymphocyte proliferation by Lycium barbarum glycopeptide. J. Huazhong Univ. Sci. Technol. Med. Sci. 24: 518-520.
7. Deng, H. B., D. P. Cui, J. M. Jiang, Y. C. Feng, N. S. Cai, and D. D. Li. 2003. Inhibiting effects of Achyranthes bidentata polysaccharide and Lycium barbarum polysaccharide on nonenzyme glycation in D-galactose induced mouse aging model. Biomed. Environ. Sci. 16: 267-275.
8. Yu, M. S., C. S. Lai, Y. S. Ho, S. Y. Zee, K. F. So, W. H. Yuen, and R. C. Chang. 2007. Characterization of the effects of anti-aging medicine Fructus lycii on β-amyloid peptide neurotoxicity. Int. J. Mol. Med. 20: 261-268.
9. Li, X. M., Y. L. Ma, and X. J. Liu. 2007. Effect of the Lycium barbarum polysaccharides on age-related oxidative stress in aged mice. J. Ethnopharmacol. 111: 504-511.
10. Li, X. M. 2007. Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats. Int. J. Biol. Macromol. 40: 461-465.
11. Ha, K. T., S. J. Yoon, D. Y. Choi, D. W. Kim, J. K. Kim, and C. H. Kim. 2005. Protective effect of Lycium chinense fruit on carbon tetrachloride-induced hepatotoxicity. J. Ethnopharmacol. 96: 529-535.
12. Luo, Q., Y. Cai, J. Yan, M. Sun, and H. Corke. 2004. Hypoglycemic and hypolipidemic effects and antioxidant activity of fruit extracts from Lycium barbarum. Life Sci. 76: 137-149.
13. Gong, H., P. Shen, L. Jin, C. Xing, and F. Tang. 2005. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on irradiation or chemotherapy-induced myelosuppressive mice. Cancer Biother. Radiopharm. 20: 155-162.
14. Gong, H., P. Shen, L. Jin, C. Xing, and F. Tang. 2004. Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. J. Exp. Ther. Oncol. 4: 181-187.
15. Zhang, M., H. Chen, J. Huang, Z. Li, C. Zhu, and S. Zhang. 2005. Effect of Lycium barbarum polysaccharide on human hepatoma QGY7703 cells: inhibition of proliferation and induction of apoptosis. Life Sci. 76: 2115-2124.
16. Chao, J. C., S. W. Chiang, C. C. Wang, Y. H. Tsai, and M. S. Wu. 2006. Hot water-extracted Lycium barbarum and Rehmannia glutinosa inhibit proliferation and induce apoptosis of hepatocellular carcinoma cells. World J. Gastroenterol. 12: 4478-4484.
17. Banchereau, J., F. Briere, C. Caux, J. Davoust, S. Lebecque, Y. J. Liu, B. Pulendran, and K. Palucka. 2000. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18: 767-811.
18. Guermonprez, P., J. Valladeau, L. Zitvogel, C. Théry, and S. Amigorena. 2002. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 20: 621-667.
19. Wilson, N. S., and J. A. Villadangos. 2005. Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications. Adv. Immunol. 86: 241-305.
20. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J. Exp. Med. 179: 1109-1118.
21. Winzler, C., P. Rovere, M. Rescigno, F. Granucci, G. Penna, L. Adorini, V. S. Zimmermann, J. Davoust, and P. Ricciardi-Castagnli. 1997. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J. Exp. Med. 185: 317-328.
22. Roake, J. A., A. S. Rao, P. J. Morris, C. P. Larsen, D. F. Hankins, and J. M. Austyn. 1995. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J. Exp. Med. 181: 2237-2247.
23. Chen, Z., B. K. Tan, and S. H. Chan. 2008. Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L. Int. Immunopharmacol. 8: 1663-1671.
24. Dubois, M., W. Pigman, J. K. Hamilton, P. A. Rebers, and F. Smith. 1956. Colorimetric method for determination of sugars and related substances. Ann. Chem. 28: 350-356.
25. Inaba, K., M. Inaba, N. Romani, H. Aya, M. Deguchi, S. Ikehara, S. Muramatsu, and R. M. Steinman. 1992. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176: 1693-1702.
26. Lutz, M. B., N. Kukutsch, A. L. Ogilvie, S. Rössner, F. Koch, N. Romani, and G. Schuler. 1999. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223: 77-92.
27. Steinman, R. M., and M. D. Witmer. 1978. Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice. Proc. Natl. Acad. Sci. USA 75: 5132-5136.
28. Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and G. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170: 827-845.
29. Kubin, M., J. M. Chow, and G. Trinchieri. 1994. Differential regulation of interleukin-12 (IL-12), tumor necrosis factor α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 83: 1847-1855.
30. + T cells. J. Immunol. 154: 5071-5079.
31. Kapsenberg, M. L. 2003. Dendritic-cell control of pathogen-driven T-cell polarization. Nat. Rev. Immunol. 3: 984-993.
32. Gubler, U., A. O. Chua, D. S. Schoenhaut, C. M. Dwyer, W. McComas, R. Motyka, N. Nabavi, A. G. Wolitzky, P. M. Quinn, and P. C. Familletti. 1991. Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. Proc. Natl. Acad. Sci. USA 88: 4143-4147.
33. Segura, M., Z. Su, C. Piccirillo, and M. M. Stevenson. 2007. Impairment of dendritic cell function by excretory-secretory products: a potential mechanism for nematode-induced immunosuppression. Eur. J. Immunol. 37: 1887-1904.
34. Robertson, M. J., and J. Ritz. 1996. Interleukin 12: basic biology and potential applications in cancer treatment. Oncologist 1: 88-97.
35. Reis e Sousa, C. 2006. Dendritic cells in a mature age. Nat. Rev. Immunol. 6: 476-683.