Regulation of IFN-α/β, MxA, 2′,5′-Oligoadenylate Synthetase, and HLA Gene Expression in Influenza A-Infected Human Lung Epithelial Cells

Journal of Immunology

Volumn 158, Issue 5, 1997, Pages 2363-2374

  Ronni, Tapani ^a   Matikainen, Sampsa ^a   Sareneva, Timo ^a   Melén, Krister ^a   Pirhonen, Jaana ^a   Keskinen, Päivi ^a   Julkunen, Ilkka ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ANTIVIRUS AGENT; BETA INTERFERON; CORE PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; HLA ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; MESSENGER RNA; MYXOVIRUS RESISTANCE PROTEINS; NP PROTEIN; NUCLEOCAPSID PROTEIN; NUCLEOPROTEIN; PROTEIN; VIRUS PROTEIN;

ADENOCARCINOMA; ARTICLE; BIOSYNTHESIS; CELL CULTURE; EPITHELIUM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INFLUENZA; INFLUENZA VIRUS A; KINETICS; LUNG; LUNG TUMOR; METABOLISM; PROTEIN BINDING; PROTEIN SYNTHESIS; VIROLOGY;

2',5'-OLIGOADENYLATE SYNTHETASE; ADENOCARCINOMA; ANTIVIRAL AGENTS; EPITHELIUM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, VIRAL; GTP-BINDING PROTEINS; HLA ANTIGENS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERFERON TYPE I; INTERFERON-BETA; KINETICS; LUNG; LUNG NEOPLASMS; NF-KAPPA B; NUCLEOCAPSID PROTEINS; NUCLEOPROTEINS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEINS; RNA, MESSENGER; TUMOR CELLS, CULTURED; VIRAL CORE PROTEINS; VIRAL PROTEINS;

EID: 0031093544     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Murphy, B. R., and R. G. Webster. 1990. Orthomyxoviruses. In Virology, B. N. Fields, D. M. Knipe, R. M. Chanock, M. S. Hirsch, J. L. Melnick, T. P. Monath, and B. Roizman, eds. Raven Press, New York, p. 1091.
2. Sen, G. C., and R. M. Ransohoff. 1993. Interferon-induced antiviral actions and their regulation. Adv. Virus Res. 42:57.
3. Ramsay, A. J., J. Ruby, and I. A. Ramshaw. 1993. A case for cytokines as effector molecules in the resolution of virus infection. Immunol. Today 14:155.
4. Larrick, J. W., and S. C. Wright. 1992. Modulation of viral infections by cytokines. Mol. Biother. 4:87.
5. Müller, U., U. Steinhoff, L. F. L. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918.
6. Samuel, C. E. 1991. Antiviral actions of interferon: interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1.
7. Staeheli, P. 1990. Interferon-induced proteins and the antiviral state. Adv. Virus Res. 38:147.
8. Staeheli, P., O. Haller, W. Boll, J. Lindenmann, and C. Weissmann. 1986. Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell 44:147.
9. Schnorr, J.-J., S. Schneider-Schaulies, A. Simon-Jödicke, J. Pavlovic, M. A. Horisberger, and V. ter Meulen. 1993. MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line. J. Virol. 67:4760.
10. Pavlovic, J., T. Zürcher, O. Haller, and P. Staeheli. 1990. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J. Virol. 64:3370.
11. Frese, M., G. Kochs, H. Feldmann, C. Hertkorn, and O. Haller. 1996. Inhibition of bunyaviruses, phleboviruses, and hantaviruses by human MxA protein. J. Virol. 70:915.
12. Nakayama, M., K. Nagata, A. Kato, and A. Ishihama. 1991. Interferon-inducible mouse Mx1 protein that confers resistance to influenza virus is GTPase. J. Biol. Chem. 266:21404.
13. Horisberger, M. A. 1992. Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins. J. Virol. 66:4705.
14. Melén, K., T. Ronni, T. Lotta, and I. Julkunen. 1994. Enzymatic characterization of interferon-induced antiviral GTPases murine Mx1 and human MxA proteins. J. Biol. Chem. 269:2009.
15. Pitossi, F., A. Blank, A. Schröder, A. Schwarz, P. Hüssi, M. Schwemmle, J. Pavlovic, and P. Staeheli. 1993. A functional GTP-binding motif is necessary for antiviral activity of Mx proteins. J. Virol. 67:6726.
16. Melen, K., and I. Julkunen. 1994. Mutational analysis of murine Mx1 protein: GTP binding core domain is essential for anti-influenza A activity. Virology 205:269.
17. Krug, R. M., M. Shaw, B. Broni, G. Shapiro, and O. Haller. 1985. Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product. J. Virol. 56:201.
18. Stranden, A. M., P. Staeheli, and J. Pavlovic. 1993. Function of the mouse Mx1 protein is inhibited by overexpression of the PB2 protein of influenza virus. Virology 197:642.
19. Pavlovic, J., O. Haller, and P. Staeheli. 1992. Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle. J. Virol. 66: 2564.
20. Ronni, T., T. Sareneva, J. Pirhonen, and I. Julkunen. 1995. Activation of JFN-α, IFN-γ, MxA, and IFN regulatory factor 1 genes in influenza A virus-infected human peripheral blood mononuclear cells. J. Immunol. 154:2764.
21. Accolla, R. S., L. Adorini, S. Sartoris, F. Sinigaglia, and J. Guardiola. 1995. MHC: orchestrating the immune response. Immunol. Today 16:8.
22. Hanke, T., and R. E. Randall. 1994. Processing of viral proteins for presentation by molecules of the major histocompatibility complex. Rev. Med. Virol. 4:47.
23. Richman, D. D., B. R. Murphy, S. Baron, and C. Uhlendorf. 1976. Three strains of influenza A virus (H3N2): interferon sensitivity in vitro and interferon production in volunteers. J. Clin. Microbiol. 3:223.
24. Peschke, T., A. Bender, M. Nain, and D. Gemsa. 1993. Role of macrophage cytokines in influenza A virus infections. Immunobiology 189:340.
25. Roberts, N. J., Jr., R. G. Douglas, Jr., R. M. Simons, and M. E. Diamond. 1979. Virus-induced interferon production by human macrophages. J. Immunol. 123: 365.
26. Cantell, K., S. Hirvonen, H.-L. Kauppinen, and G. Myllylä. 1981. Production of interferon in human leukocytes from normal donors with the use of Sendai virus. Methods Enzymol. 78:29.
27. Cantell, K., S. Hirvonen, and H.-L. Kauppinen. 1986. Production and partial purification of human immune interferon. Methods Enzymol. 119:54.
28. WHO Collaborating Centers for Reference and Research on Influenza. 1982. Concepts and Procedures for Laboratory-Based Influenza Surveillance. U. S. Department of Health and Human Services, National Institutes of Health, Bethesda, MD.
29. Ronni, T., K. Melén, A. Malygin, and I. Julkunen. 1993. Control of IFN-inducible MxA gene expression in human cells. J. Immunol. 150:1715.
30. Mogensen, K. E., L. Pyhälä, and K. Cantell. 1975. Raising antibodies to human leukocyte interferon. Acta Pathol. Microbiol. Scand. Suppl. 83:443.
31. Julkunen, I., A. Hautanen, and J. Keski-Oja. 1983. Interaction of viral envelope glycoproteins with fibronectin. Infect Immun. 40:876.
32. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
33. Cantell, K., S. Hirvonen, H.-L. Kauppinen, and N. Kalkkinen. 1991. Rapid production of interferon-γ in uninduced human leukocyte suspensions. J. Interferon Res. 11:231.
34. Chirgwin, J. M., A. E. Przybyla, R. J. MacDonald, and W. J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294.
35. Glišin, V., R. Crkvenjakov, and C. Byus. 1974. Ribonucleic acid isolated by cesium chloride centrifugation. Biochemistry 13:2633.
36. Young, J. F., U. Desselberger, P. Graves, P. Palese, A. Shatzman, and M. Rosenberg. 1983. Cloning and expression of influenza virus genes. In The Origin of Pandemic Influenza Viruses. W. G. Laver, ed. Elsevier Science Publishing Co., New York, p. 129
37. Benech, P., Y. Mory, M. Revel, and J. Chebath. 1985. Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences. EMBO J. 4:2249.
38. Ponte, P., S.-Y. Ng, J. Engel, P. Gunning, and L. Kedes. 1984. Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res. 12:1687.
39. Huang, Z., M. J. Fasco, and L. S. Kaminsky. 1996. Optimization of DNase I removal of contaminating DNA from RNA for use in quantitative RNA-PCR. Biotechniques 20:1012.
40. Foley, K. P., M. W. Leonard, and J. D. Engel. 1993. Quantitation of RNA using the polymerase chain reaction. Trends Genet. 9:380.
41. Andrews, N. C., and D. V. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limited numbers of mammalian cells. Nucleic Acids Res. 19:2499.
42. Matikainen, S., T. Ronni, M. Hurme, R. Pine, and I. Julkunen. 1996. Retinoic acid activates interferon regulatory factor-1 gene expression in myeloid cells. Blood 88:114.
43. Bender, A., U. Amann, R. Jäger, M. Nain, and D. Gemsa. 1993. Effect of granulocyte/macrophage colony-stimulating factor on human monocytes infected with influenza A virus: enhancement of virus replication, cytokine release, and cytotoxicity. J. Immunol. 151:5416.
44. Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80: 529.
45. Simon, A., J. Fäh, O. Haller, and P. Staeheli. 1991. Interferon-regulated Mx genes are not responsive to interleukin-1, tumor necrosis factor, and other cytokines. J. Virol. 65:968.
46. Aebi, M., J. Fäh, N. Hurt, C. E. Samuel, D. Thomis, L. Bazzigher, J. Pavlovic, O. Haller, and P. Staeheli. 1989. cDNA structures and regulation of two interferon-induced human Mx proteins. Mol. Cell. Biol. 9:5062.
47. Goetschy, J.-F., H. Zeller, J. Content, and M. A. Horisberger. 1989. Regulation of the interferon-inducible IFI-78K gene, the human equivalent of the murine Mx gene, by interferons, double-stranded RNA, certain cytokines, and viruses. J. Virol. 63:2616.
48. Krug, R. M., F. V. Alonso-Caplen, I. Julkunen, and M. G. Katze. 1989. Expression and replication of the influenza virus genome. In The Influenza Viruses. R. M. Krug, ed. Plenum Publishing Corporation, New York, p. 89.
49. Lieber, M., B. Smith, A. Szakal, W. Nelson-Rees, and G. Todaro. 1976. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int. J. Cancer 17:62.
50. Smith, C. D., D. W. Craft, R. S. Shiromoto, and P. O. Yan. 1986. Alternative cell line for virus isolation. J. Clin. Microbiol. 24:265.
51. Zhu, Z., W. Tang, A. Ray, Y. Wu, O. Einarsson, M. L. Landry, J. Gwaltney, Jr., and J. A. Elias. 1996. Rhinovirus stimulation of interleukin-6 in vivo and in vitro: evidence of nuclear factor κB-dependent transcriptional activation. J. Clin. Invest. 97:421.
52. Staeheli, P., and O. Haller. 1985. Interferon-induced human protein with homology to protein Mx of influenza virus-resistant mice. Mol. Cell. Biol. 5:2150.
53. Baldwin, A. S. 1996. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
54. Pahl, H. L., and P. A. Bauerle. 1995. Expression of influenza virus hemagglutinin activates transcription factor NF-κB. J. Virol. 69:1480.
55. Daly, C., and N. C. Reich. 1995. Characterization of specific DNA-binding factors activated by double-stranded RNA as positive regulators of interferon α/β-stimulated genes. J. Biol. Chem. 270:23739.
56. Saunders, M. E., D. R. Gewert, M. E. Tugwell, M. McMahon, and B. R. G. Williams. 1985. Human 2-5A synthetase: characterization of a novel cDNA and corresponding gene structure. EMBO J. 4:1761.
57. Marie, I., and A. G. Hovanessian. 1992. The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains. J. Biol. Chem. 267: 9933.
58. Witt, P. L., I. Marié, N. Robert, A. Irizarry, E. C. Borden, and A. G. Hovanessian. 1993. Isoforms p69 and p100 of 2′.5′-oligoadenylate synthetase induced differentially by interferons in vivo and in vitro. J. Interferon Res. 13:17.
59. David-Watine, B., A. Israël, and P. Kourilsky. 1990. The regulation and expression of MHC class I genes. Immunol. Today 11:286.
60. Dhib-Jalbut, S. S., and E. P. Cowan. 1993 Direct evidence that interferon-β mediates enhanced HLA-class I expression in measles virus-infected cells. J. Immunol. 151:6248.
61. Reith, W., V. Steimle, and B. Mach. 1995. Molecular defects in the bare lymphocyte syndrome and regulation of MHC class II genes. Immunol. Today 16: 539.
62. Cunningham, A. C., and J. A. Kirby. 1995. Regulation and function of adhesion molecule expression by human alveolar epithelial cells. Immunology 86:279.
63. Karupiah, G., Q.-W. Xie, R. M. L. Buller, C. Nathan, C. Duarte, and J. D. MacMicking. 1993. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science 261:1445.
64. Asano, K., C. B. E. Chee, B. Gaston, C. M. Lilly, C. Gerard, J. M. Drazen, and J. S. Stamler. 1994. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91:10089.
65. Farrar, M. A., and R. D. Schreiber. 1993. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11:571.
66. Vacheron, F., A. Rudent, S. Perin, C. Labarre, A. M. Quero, and M. Guenounou. 1990. Production of interleukin 1 and tumour necrosis factor activities in bronchoalveolar washings following infection of mice by influenza virus. J. Gen. Virol. 71:477.
67. Hennet, T., H. J. Ziltener, K. Frei, and E. Peterhans. 1992. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. J. Immunol. 149:932.