Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model

Molecular Cancer

Volumn 11, Issue , 2012, Pages

  Tsunoda, Toshiyuki ^a   Ota, Takeharu ^a   Fujimoto, Takahiro ^a   Doi, Keiko ^a   Tanaka, Yoko ^a   Yoshida, Yasuhiro ^a   Ogawa, Masahiro ^a   Matsuzaki, Hiroshi ^a   Hamabashiri, Masato ^a   Tyson, Darren R ^b   Kuroki, Masahide ^a   Miyamoto, Shingo ^a   Shirasawa, Senji ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AKT; Colorectal cancer; Kras; PDE4B; Three dimensional culture

Indexed keywords

CASPASE 3; K RAS PROTEIN; MESSENGER RNA; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVB; PROTEIN KINASE B; PROTEIN ZO1; ROLIPRAM; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CATALYSIS; COLORECTAL CANCER; ENZYME INHIBITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN DEPHOSPHORYLATION; UPREGULATION;

APOPTOSIS; CELL LINE, TUMOR; CLUSTER ANALYSIS; COLORECTAL NEOPLASMS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, RAS; HCT116 CELLS; HUMANS; PHOSPHODIESTERASE 4 INHIBITORS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECURRENCE; RNA INTERFERENCE; ROLIPRAM; SPHEROIDS, CELLULAR; TIGHT JUNCTIONS; TUMOR CELLS, CULTURED;

EID: 84866176492     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-11-46     Document Type: Article

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