Humoral markers of severity and prognosis of critical illness

Best Practice and Research: Clinical Endocrinology and Metabolism

Volumn 15, Issue 4, 2001, Pages 553-573

  Nylén, Eric S ^a   Alarifi, Abdullah A ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

C reactive protein; Calcitonin precursors; Critical illness; Cytokine markers and illness outcome; Cytokines; High mobility group I; Hormone markers and illness outcome; Illness severity and outcome; Natriuretic hormones; Neurocrine markers and illness outcome

Indexed keywords

ACTIVATED PROTEIN C; ACUTE PHASE PROTEIN; ADENOSINE; ARACHIDONIC ACID; C REACTIVE PROTEIN; CALCITONIN; CELL ADHESION MOLECULE; CYTOKINE; DNA BINDING PROTEIN; ENDOTHELIN; ESTERASE; FAS LIGAND; HYDROCORTISONE; INTERLEUKIN 6; LEPTIN; MACROPHAGE MIGRATION INHIBITION FACTOR; NATRIURETIC FACTOR; NITRIC OXIDE; SERUM AMYLOID A; THROMBOCYTE ACTIVATING FACTOR; THYROID HORMONE;

APOPTOSIS; CENTRAL NERVOUS SYSTEM FUNCTION; CRITICAL ILLNESS; CYTOKINE RELEASE; DISEASE SEVERITY; ENDOCRINE FUNCTION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; PATHOGENESIS; PATHOPHYSIOLOGY; PREDICTION; PROGNOSIS; PROTEIN BLOOD LEVEL; REVIEW; TRANSCRIPTION REGULATION;

EID: 0035746523     PISSN: 1521690X     EISSN: None     Source Type: Journal    
DOI: 10.1053/beem.2001.0169     Document Type: Article

References (160)

1. An overview of mortality risk prediction in sepsis
2. Plasma proinflammatory cytokine concentrations, Acute Physiology and Chronic Health Evaluation (APACHE)III scores and survival in patients in an intensive care unit
3. Endocrine markers and mediators in critical illness
4. Prediction of outcome in intensive care patients using endocrine parameters
5. Endocrine profiles for outcome prediction from the intensive care unit
6. Dislodging sacred dogmas in combating systemic stress: The case for steroids
7. Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release
8. The role of mediators in the response to thermal injury
9. Enhanced urinary excretion of leukotriene E4 by patients with multiple trauma with or without adult respiratory distress syndrome
10. Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome: Mortality prognostic study
11. Cysteinyl-leukotriene generation as a biomarker for survival in the critically ill
12. Detrimental effects of nitric oxide synthase inhibitor (N-ω-nitro-L-arginine-methyl ester) in a murine sepsis model
13. Nitric oxide production is increased in patients after burn injury
14. Overproduction of nitric oxide in cytokine-mediated and septic shock
15. Nitric oxide production is enhanced in patients with heat stroke
16. Nitric oxide: A predictor of morbidity in postoperative patients?
17. Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis
18. Early posttraumatic increase in production of nitric oxide in humans
19. Endothelins
20. Elevated plasma levels of endothelin in patients with sepsis syndrome
21. Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis
22. Plasma levels of TNF alpha, endothelin-1 and thrombomodulin in patients with sepsis
23. Circulating endothelin-1 and tumor necrosis factor alpha: Early predictors of mortality in patients with septic shock
24. Evidence for endothelial cell activation/injury in heatstroke
25. Direct comparison between endothelin-1, N-terminal proatrial natriuretic factor, and brain natriuretic peptide as prognostic markers of survival in congestive heart failure
26. Prognostic value of plasma endothelin-1 in patients with chronic heart failure
27. Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: Possible role of endothelin and atrial natriuretic hormone
28. Serum calcitonin precursors in sepsis and systemic inflammation
29. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit
30. Effects of anti-inflammatory agents on serum levels of calatonin precursers during human experimental endotoxemia
31. Disordered calcium homeostasis of sepsis and association with calcitonin precursors
32. Mortality is increased by procalcitonin and decreased by an antiserum reactive to procalcitonin in experimental sepsis
33. Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis
34. Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm, in cortisol and leptin secretion
35. Leptin and interleukin-6 in sepsis
36. Relationship of plasma leptin to plasma cytokines and human survival in sepsis and septic shock
37. The coordinated cytokine/hormone response to acute injury incorporates leptin
38. Leptin levels in protracted critical illness: Effects of growth hormone-secretagogues and thyrotropin-releasing hormone
39. Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans
40. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor
41. Elevation of plasma adenosine levels may attenuate the severity of chronic heart failure
42. High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock
43. Plasma levels of high-energy compounds compared with severity of illness in critically ill patients in the intensive care unit
44. Endotoxin-induced hypocalcemia results in defective calcium mobilization in rats
45. Ionized hypocalcemia in critically ill patients with sepsis
46. Prevalence and clinical implications of hypocalcemia in acutely ill patients in a medical intensive care setting
47. Development of postoperative insulin resistance is associated with the magnitude of operation
48. The relationships between plasma substrates and hormones and the severity of injury in 277 recently injured patients
49. Blood sugar and insulin response of humans in shock
50. Blood glucose and prognosis of acute stroke
51. Determinants and importance of stress hyperglycaemia in non-diabetic patients with myocardial infarction
52. Prognostic importance of hyperglycaemia induced by stress after acute myocardial infarction
53. The influence of hyperglycemia and diabetes mellitus on immediate and 3-month morbidity and mortality after acute stroke
54. Relationship between admission hyperglycemia and neurologic outcome of severely brain-injured patients
55. Neurologic outcome and blood glucose levels during out-of-hospital cardiopulmonary resuscitation
56. Oxygen delivery in critically ill patients. Relationship to blood lactate and survival
57. Serial lactate determinations during circulatory shock
58. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock)
59. Scoring systems and blood lactate concentrations in relation to the development of adult respiratory distress syndrome and multiple organ failure in severely traumatized patients
60. Serial blood lactate levels can predict the development of multiple organ failure following septic shock
61. Lactate clearance and survival following injury
62. The prognostic value of hypocholesterolemia in hospitalized patients
63. Low lipid concentrations in critical illness: Implications for preventing and treating endotoxemia
64. Serum cholesterol and mortality in patients with multiple organ failure
65. Association of tumour necrosis factor-2 allele with plasma tumour necrosis factor-alpha levels and mortality from septic shock
66. Unintended immunomodulation: Effects of common clinical conditions on cytokine biosynthesis
67. Serum tumor necrosis factor levels in patients with infectious disease and septic shock
68. The value of immune modulating parameters in predicting the progression from peritonitis to septic shock
69. Soluble cytokine receptors and receptor antagonists are sequentially released after trauma
70. Elevation of circulating interleukin 6 after surgery: Factors influencing the serum level
71. Circulating interleukin-1 beta and tumor necrosis factor-alpha concentrations after burn injury in humans
72. Plasma tumor necrosis factor and mortality in critically ill septic patients
73. Cytokines and their interactions with other inflammatory mediators in the pathogenesis of sepsis and septic shock
74. Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe septis: The RAMSES Study
75. Prognostic value of serum cytokines in patients with congestive heart failure
76. Interleukin-8 in sepsis: Relation to shock and inflammatory mediators
77. Circulating interleukin-8 concentrations in patients with multiple organ failure of septic and nonseptic origin
78. Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis
79. Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: A novel marker of disease activity
80. Increased concentrations of plasma IL-18 in patients with hepatic dysfunction after hepatectomy
81. Interleukin 18 (IL-18) levels in patients with sepsis
82. Interleukin 12 levels during the initial phase of septic shock with purpura in children: Relation to severity of disease
83. Elevated plasma concentrations of interferon (IFN)-gamma and the IFN-gamma-inducing cytokines interleukin (IL)-18, IL-12, and IL-15 in severe melioidosis
84. Lymphocyte activation after non-thermal trauma
85. Soluble tumor necrosis factor receptors are elevated in relation to severity of congestive heart failure
86. Changes in blood lymphocyte populations after multiple trauma: Association with posttraumatic complications
87. Release of tumor necrosis factor alpha and its soluble receptor p55 in clinical septic syndrome
88. Interleukin 1 receptor antagonist and E-selectin concentrations: A comparison in patients with severe acute pancreatitis and severe sepsis
89. Acute-phase proteins and other systemic responses to inflammation
90. Re-establishment of homeostasis and the acute-phase proteins
91. The C-reactive protein to prealbumin ratio correlates with the severity of multiple organ dysfunction
92. 'Sepsis' and multi-organ failure: Predictors of poor outcome after hematopoietic stem cell transplantation in children
93. Correlation between serum IL-6 an CRP levels and severity of head injury in children
94. Risk factors for coronary heart disease and acute-phase proteins. A population-based study
95. Increased preoperative C-reactive protein (CRP)-values without signs of an infection and complicated course after cardiopulmonary bypass (CPB)-operations
96. Systemic inflammatory response in cardiac allograft vasculopathy: High-sensitive C-reactive protein is associated with progressive luminal obstruction
97. Acute phase proteins, C-reactive protein and serum amyloid A protein, as prognostic markers in the elderly inpatient
98. Roles of secretory phospholipases A(2) in inflammatory diseases and trauma
99. Phospolipase A2: Its usefulness in laboratory diagnostics
100. Initial serum ferritin levels in patients with multiple trauma and the subsequent development of acute respiratory distress syndrome
101. A novel acute-phase marker: Lipopolysaccharide binding protein (LBP)
102. Lipopolysaccharide binding protein in acute pancreatitis
103. Cascade system activation in shock
104. Neutrophil activation after burn injury: Contributions of the classic complement pathway and of endotoxin
105. Anaphylatoxin generation in multisystem organ failure
106. Experimental and clinical evidence of leukocyte activation in trauma and sepsis
107. Compliment activation in relation to capillary leakage in children with septic shock and purpura
108. Leukocyte responses to injury
109. Posttraumatic complications and inflammatory mediators
110. Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: A prospective cohort study
111. Do plasma levels of circulating soluble adhesion molecules differ between surviving and nonsurviving critically ill patients?
112. Soluble selectins and the systemic inflammatory response syndrome after successful cardiopulmonary resuscitation
113. Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CDIIb
114. L-selectin in trauma patients: A marker for organ dysfunction and outcome?
115. Leukocyte L-selectin is up-regulated after mechanical trauma in adults
116. Platelet-activating factor and cytokine interactions in shock
117. Intravascular release of platelet activating factor in children with sepsis
118. Production of platelet-activating factor in patients with sepsis-associated acute renal failure
119. Depressed plasma platelet-activating factor acetylhydrolase in patients presenting with acute myocardial infarction
120. Infarct volume, neurological severity and PAF binding to platelets of patients with acute cerebral ischemic stroke
121. Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: Is it an additional marker of perinatal asphyxia?
122. Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: A phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group
123. Decreased organ failure in patients with severe sepsis and septic shock treated with the platelet-activating factor antagonist TCV-309: A prospective, multicenter, double-blind, randomized phase II trial
124. Activated protein C inhibits tumor necrosis factor and macrophage migrating inhibitory factor production in monocytes
125. Prognostic value of protein C concentrations in neutropenic patients at high risk of severe septic complications
126. Recombinant human activated protein C for severe sepsis for the recombinant human activated protein C. Worldwide evaluation in severe sepsis (PROWESS) study group
127. Evidence for a role of kallikrein-kinin system in patients with shock after blunt trauma
128. The diagnostic value of changes in the kallikrein-kinin system indices in patients with acute pancreatitis
129. Disease severity is correlated with plasma clotting and fibrinolytic and kinin-kallikrein activity in neonatal respiratory distress syndrome
130. Increased plasma concentrations of brain natriuretic peptide in patients with acute lung injury
131. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
132. The bigger the burn, the greater the stress
133. N-terminal proatrial natriuretic peptide and prognosis in patients with heart failure and preserved systolic function
134. Plasma brain natriuretic peptide - An independent predictor of cardivascular mortality in acute heart failure
135. Renal function, neurohormonal activation and survival in patients with chronic heart failure
136. Associations between atrial natriuretic peptides, echocardiographic findings and mortality in an elderly population sample
137. Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin: New neurohormonal predictors of left ventricular function and prognosis after myocardial infarction
138. Calcitonin gene family of peptides
139. Alpha-melanocyte stimulating hormone in sepsis: Is your patient's brain smarter than your patient's doctor?
140. MIF, a previously unrecognized pituitary hormone and macrophage cytokine, is a pivotal mediator in endotoxic shock
141. MIF as a glucocorticoid-induced modulator of cytokine production
142. An essential regulatory role for macrophage migration inhibitory factor in T-cell activation
143. Protection from septic shock by neutralization of macrophage migration inhibitory factor
144. Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness
145. Hyperthermia induces heat-shock protein expression, reduces pancreatic injury, and improves survival in necrotizing pancreatitis
146. Heat shock response reduces mortality after severe experimental burns
147. Preinduction of heat shock proteins protects cardiac and hepatic functions following trauma and hemorrhage
148. Heat shock protein 70 messenger RNA reflects the severity of ischemia/hypoxia-reperfusion injury in the perfused rat liver
149. Patterns of heat-shock protein 70 biosynthesis following human traumatic brain injury
150. Heat shock protein (HSP70) expression in septic patients
151. Heat stress is associated with decreased lactic acidemia in rat sepsis
152. HMG-I as a late mediator of endotoxin lethality in mice
153. Predictive value of nuclear factor kappa B activity and plasma cytokine levels in patients with sepsis
154. Increased nuclear factor kappa B activation in critically ill patients who die
155. Nuclear factor kappa B activation in acute appendicitis: A molecular marker for extent of disease?
156. Defining the role of oxyradicals in the pathogenesis of sepsis
157. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk
158. Decreased antioxidant status and increased lipid peroxidation in patients with septic shock and secondary organ dysfunction
159. Soluble fas levels correlate with multiple organ dysfunction severity, survival and nitrate levels, but not with cellular apoptotic markers in critically ill patients
160. Ceramide concentrations in septic patients: A possible marker of multiple organ dysfunction syndrome