메뉴 건너뛰기




Volumn 28, Issue 2, 2006, Pages 90-94

Recombinant human activated protein C

Author keywords

Drotrecogin alfa activated; Drug therapy; Pathophysiology; Recombinant human activated protein C; Sepsis syndrome

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; DROTRECOGIN;

EID: 33746298889     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2006.05.021     Document Type: Short Survey
Times cited : (5)

References (23)
  • 1
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus D.C., Linde-Zwirble W.T., Lidicker J., Clermont G., Carcillo J., and Pinsky M.R. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29 (2001) 1303-1310
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 2
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin G.S., Mannino D.M., Eaton S., and Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348 (2003) 1546-1554
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 3
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
    • Bernard G.R., Vincent J.L., Laterre P.F., et al., Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344 (2001) 699-709
    • (2001) N Engl J Med , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.F.3
  • 4
    • 0037251850 scopus 로고    scopus 로고
    • Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials
    • Eichacker P.Q., and Natanson C. Recombinant human activated protein C in sepsis: inconsistent trial results, an unclear mechanism of action, and safety concerns resulted in labeling restrictions and the need for phase IV trials. Crit Care Med 31 Suppl. (2003) S94-S96
    • (2003) Crit Care Med , vol.31 , Issue.SUPPL
    • Eichacker, P.Q.1    Natanson, C.2
  • 5
    • 0037179678 scopus 로고    scopus 로고
    • Activated protein C for severe sepsis
    • Ely E.W., Bernard G.R., and Vincent J.L. Activated protein C for severe sepsis. N Engl J Med 347 (2002) 1035-1036
    • (2002) N Engl J Med , vol.347 , pp. 1035-1036
    • Ely, E.W.1    Bernard, G.R.2    Vincent, J.L.3
  • 6
    • 0031018409 scopus 로고    scopus 로고
    • Increasing incidence of withholding and withdrawal of life support from the critically ill
    • Prendergast T.J., and Luce J.M. Increasing incidence of withholding and withdrawal of life support from the critically ill. Am J Respir Crit Care Med 155 (2005) 15-20
    • (2005) Am J Respir Crit Care Med , vol.155 , pp. 15-20
    • Prendergast, T.J.1    Luce, J.M.2
  • 7
    • 0035434019 scopus 로고    scopus 로고
    • Sepsis syndromes: understanding the role of innate and acquired immunity
    • Oberholzer A., Oberholzer C., and Moldawer L.L. Sepsis syndromes: understanding the role of innate and acquired immunity. Shock 16 (2001) 83-96
    • (2001) Shock , vol.16 , pp. 83-96
    • Oberholzer, A.1    Oberholzer, C.2    Moldawer, L.L.3
  • 8
    • 0028937425 scopus 로고
    • Downregulation of proinflammatory cytokine release in whole blood from septic patients
    • Ertel W., Kremer J.-P., Kenney J., et al. Downregulation of proinflammatory cytokine release in whole blood from septic patients. Blood 85 (1995) 1341-1347
    • (1995) Blood , vol.85 , pp. 1341-1347
    • Ertel, W.1    Kremer, J.-P.2    Kenney, J.3
  • 9
    • 0032701390 scopus 로고    scopus 로고
    • Selective defects of T lymphocyte function in patients with lethal intraabdominal infection
    • Heidecke C.D., Hensler T., Weighardt H., et al. Selective defects of T lymphocyte function in patients with lethal intraabdominal infection. Am J Surg 178 (1999) 288-292
    • (1999) Am J Surg , vol.178 , pp. 288-292
    • Heidecke, C.D.1    Hensler, T.2    Weighardt, H.3
  • 10
    • 0032770246 scopus 로고    scopus 로고
    • Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    • Hotchkiss R.S., Swanson P.E., Freeman B.D., et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 27 (1999) 1230-1251
    • (1999) Crit Care Med , vol.27 , pp. 1230-1251
    • Hotchkiss, R.S.1    Swanson, P.E.2    Freeman, B.D.3
  • 11
    • 0036499162 scopus 로고    scopus 로고
    • Depletion of dendritic cells, but not macrophages, in patients with sepsis
    • Hotchkiss R.S., Tinsley K.W., Swanson P.E., et al. Depletion of dendritic cells, but not macrophages, in patients with sepsis. J Immunol 168 (2002) 2493-2500
    • (2002) J Immunol , vol.168 , pp. 2493-2500
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 12
    • 0035338993 scopus 로고    scopus 로고
    • Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans
    • Hotchkiss R.S., Tinsley K.W., Swanson P.E., et al. Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J Immunol 166 (2001) 6952-6963
    • (2001) J Immunol , vol.166 , pp. 6952-6963
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3
  • 13
    • 0037426726 scopus 로고    scopus 로고
    • The pathophysiology and treatment of sepsis
    • Hotchkiss R.S., and Karl I.E. The pathophysiology and treatment of sepsis. N Engl J Med 348 (2003) 138-150
    • (2003) N Engl J Med , vol.348 , pp. 138-150
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 14
    • 33746295729 scopus 로고    scopus 로고
    • Eisenberg P. Re: Discontinuation of study F1K-MC-EVBP, investigation of the efficacy and safety of drotrecogin alfa (activated) in paediatric severe sepsis (letter). http://www.fda.gov/medwatch/SAFETY/2005/xigris_dearhcp_4-21-05.htm [accessed 12 May 2006].
  • 15
    • 33746286115 scopus 로고    scopus 로고
    • Eisenberg P. Re: Important drug warning (letter). http://www.fda.gov/medwatch/SAFETY/2005/xigris_DHCP.htm [accessed 12 May 2006].
  • 16
    • 25444492831 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
    • Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group
    • Abraham E., Laterre P.F., Garg R., et al., Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med 353 (2005) 1332-1341
    • (2005) N Engl J Med , vol.353 , pp. 1332-1341
    • Abraham, E.1    Laterre, P.F.2    Garg, R.3
  • 17
    • 26444552470 scopus 로고    scopus 로고
    • Reassessing recombinant human activated protein C for sepsis: time for a new randomised controlled trial
    • Eichacker P.Q., Danner R.L., Suffredini A.F., Cui X., and Natanson C. Reassessing recombinant human activated protein C for sepsis: time for a new randomised controlled trial. Crit Care Med 33 (2005) 2426-2428
    • (2005) Crit Care Med , vol.33 , pp. 2426-2428
    • Eichacker, P.Q.1    Danner, R.L.2    Suffredini, A.F.3    Cui, X.4    Natanson, C.5
  • 18
    • 8544268686 scopus 로고    scopus 로고
    • The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis
    • PROWESS Investigators
    • Angus D.C., Laterre P.F., Helterbrand J., et al., PROWESS Investigators. The effect of drotrecogin alfa (activated) on long-term survival after severe sepsis. Crit Care Med 32 (2004) 2199-2206
    • (2004) Crit Care Med , vol.32 , pp. 2199-2206
    • Angus, D.C.1    Laterre, P.F.2    Helterbrand, J.3
  • 19
    • 33746281780 scopus 로고    scopus 로고
    • Tanzi M. Use of drotrecogin alfa activated for the treatment of severe sepsis - medical use evaluation by Novation - the medical supply company of VHA & UHC. Novation, 2004.
  • 20
    • 26444604781 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) treatment in severe sepsis from the global open label trial ENHANCE: further evidence for survival and implications for early treatment
    • Vincent J.L., Bernard G.R., Beale R., et al. Drotrecogin alfa (activated) treatment in severe sepsis from the global open label trial ENHANCE: further evidence for survival and implications for early treatment. Crit Care Med 33 (2005) 2266-2277
    • (2005) Crit Care Med , vol.33 , pp. 2266-2277
    • Vincent, J.L.1    Bernard, G.R.2    Beale, R.3
  • 21
    • 31344447152 scopus 로고    scopus 로고
    • Recombinant activated protein C: decisions for administration
    • Dellinger R.P. Recombinant activated protein C: decisions for administration. Crit Care Med 34 (2006) 530-531
    • (2006) Crit Care Med , vol.34 , pp. 530-531
    • Dellinger, R.P.1
  • 22
    • 0030892967 scopus 로고    scopus 로고
    • Physicians' survival predictions for patients with acute congestive heart failure
    • Poses R.M., Smith W.R., McClish D.K., et al. Physicians' survival predictions for patients with acute congestive heart failure. Arch Intern Med 157 (1997) 1001-1007
    • (1997) Arch Intern Med , vol.157 , pp. 1001-1007
    • Poses, R.M.1    Smith, W.R.2    McClish, D.K.3
  • 23
    • 2442458881 scopus 로고    scopus 로고
    • Clinician predictions of intensive care unit mortality
    • Level of Cave Study Investigators; Canadian Critical Care Trials Group
    • Rocker G., Cook D., Sjokvist P., et al., Level of Cave Study Investigators; Canadian Critical Care Trials Group. Clinician predictions of intensive care unit mortality. Crit Care Med 32 (2006) 1149-1154
    • (2006) Crit Care Med , vol.32 , pp. 1149-1154
    • Rocker, G.1    Cook, D.2    Sjokvist, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.