Sea-anemone toxin ATX-II elicits A-fiber-dependent pain and enhances resurgent and persistent sodium currents in large sensory neurons

Molecular Pain

Volumn 8, Issue , 2012, Pages

  Klinger, Alexandra B ^a   Eberhardt, Mirjam ^a   Link, Andrea S ^a   Namer, Barbara ^a   Kutsche, Lisa K ^a   Schuy, E T ^a   Sittl, Ruth ^b   Hoffmann, Tali ^a   Alzheimer, Christian ^a   Huth, Tobias ^a   Carr, Richard W ^c   Lampert, Angelika ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Differential nerve block; Itch; Patch clamp; Psychophysics; RT qPCR; SCN4b; Sensory neurons; Sodium channels

Indexed keywords

MESSENGER RNA; SEA ANEMONE TOXIN; SEA ANEMONE TOXIN ATX II; SODIUM CHANNEL; SODIUM CHANNEL BETA4; SODIUM CHANNEL NAV1.6; SODIUM CHANNEL NAV1.7; UNCLASSIFIED DRUG;

AFFERENT NERVE GROUP 1; ANIMAL CELL; ARTICLE; AXON REFLEX ERYTHEMA; CARBOXY TERMINAL SEQUENCE; CELL ACTIVATION; CELL LINE; CELL STRAIN HEK293; CELL STRAIN N1E115; ERYTHEMA; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LASER DOPPLER FLOWMETRY; MOUSE; NERVE BLOCK; NERVE FIBER; NERVE FIBER C; NOCICEPTION; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PAIN; PARESTHESIA; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SUBUNIT; PRURITUS; REAL TIME POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SKIN BLOOD FLOW; SODIUM CURRENT; SPINAL GANGLION; WHOLE CELL;

ANIMALS; CNIDARIAN VENOMS; EXTRACELLULAR SPACE; FEMALE; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; INJECTIONS, INTRADERMAL; ION CHANNEL GATING; MALE; MICE; NAV1.6 VOLTAGE-GATED SODIUM CHANNEL; NAV1.7 VOLTAGE-GATED SODIUM CHANNEL; NERVE FIBERS, MYELINATED; PAIN; PEPTIDES; PRURITUS; SENSORY RECEPTOR CELLS; SODIUM CHANNELS; TIME FACTORS;

EID: 84866168319     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-69     Document Type: Article

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