Riluzole-triggered GSH synthesis via activation of glutamate transporters to antagonize methylmercury-induced oxidative stress in rat cerebral cortex

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Deng, Yu ^a   Xu, Zhao Fa ^a   Liu, Wei ^a   Xu, Bin ^a   Yang, Hai Bo ^a   Wei, Yan Gang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL APOPTOSIS; CEREBRAL CORTEX; CONTROL GROUPS; DOWN-REGULATION; FOUR-GROUP; FUNCTION AND EXPRESSION; GLUTAMATE TRANSPORTERS; GLUTATHIONES; MALONDIALDEHYDE; METHYL MERCURY; MRNA EXPRESSION; NEUROTOXICITY; PATHOLOGICAL CHANGES; PROTEIN LEVEL; REACTIVE OXYGEN SPECIES; RILUZOLE;

ALDEHYDES; AMINO ACIDS; BIOINFORMATICS; CHEMICAL ACTIVATION; MERCURY (METAL); MERCURY COMPOUNDS; OXIDATIVE STRESS; RATS;

CELL DEATH;

8 HYDROXYDEOXYGUANOSINE; CARBONYL DERIVATIVE; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; MALONALDEHYDE; MESSENGER RNA; METHYLMERCURY; REACTIVE OXYGEN METABOLITE; RILUZOLE; VESICULAR GLUTAMATE TRANSPORTER 1; 8-HYDROXY-2'-DEOXYGUANOSINE; DEOXYGUANOSINE; DRUG DERIVATIVE; EXCITATORY AMINO ACID TRANSPORTER 2; METHYLMERCURY DERIVATIVE; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GLUTATHIONE METABOLISM; MALE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; RAT; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; PATHOLOGY; WISTAR RAT;

RATTUS;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; APOPTOSIS; CEREBRAL CORTEX; DEOXYGUANOSINE; DOWN-REGULATION; EXCITATORY AMINO ACID TRANSPORTER 2; FEMALE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; MALE; MALONDIALDEHYDE; METHYLMERCURY COMPOUNDS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; RILUZOLE;

EID: 84866144215     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/534705     Document Type: Article

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