Riluzole Enhances Glutamate Uptake in Rat Astrocyte Cultures

Cellular and Molecular Neurobiology

Volumn 24, Issue 1, 2004, Pages 123-128

  Dos Santos Frizzo, Marcos Emílio ^a   Dall'Onder, Leonara Patrícia ^a   Dalcin, Karina Borges ^a   Souza, Diogo Onofre ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Amyotrophic lateral sclerosis; Astrocyte culture; Glutamate uptake; Neuroprotection; Riluzole

Indexed keywords

GLUTAMIC ACID; RILUZOLE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN ISCHEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUNTINGTON CHOREA; NEUROMODULATION; NEUROPROTECTION; NEUROTRANSMITTER RELEASE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SYNAPSE;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BRAIN ISCHEMIA; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMIC ACID; NEURODEGENERATIVE DISEASES; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RILUZOLE; SYNAPSES; SYNAPTIC TRANSMISSION;

ANIMALIA;

EID: 1242321225     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:CEMN.0000012717.37839.07     Document Type: Article

References (11)

1. Anderson, C. M., and Swanson, R. A. (2000). Astrocyte glutamate transport: Review of properties, regulation, and physiological functions. Glia 32(1):1-14.
2. Azbill, R. D., Mu, X., and Springer, J. E. (2000). Riluzole increases high-affinity glutamate uptake in rat spinal cord synaptosomes. Brain Res. 871:175-180.
3. Bodner, Th., Jenner, C., Benke, Th., Ober, A., Seppi, K., and Fleischhacker, W. W. (2001). Intoxication with riluzole in Huntington's disease. Neurology 57:1141-1143.
4. Danbolt, N. C. (2001). Glutamate uptake. Prog. Neurobiol. 65:1-105.
5. Doble, A. (1996). The pharmacology and mechanism of action of riluzole. Neurology 47(4):233S-241S.
6. Dunlop, J., McIlvain, H. B., She, Y., and Howland, D. S. (2003). Impaired spinal cord glutamate transport capacity and reduced sensitivity to riluzole in a transgenic superoxide dismutase mutant rat model of amyotrophic lateral sclerosis. J. Neurosci. 23(5):1688-1695.
7. Frizzo, M. E. S., Lara, D. R., Dahm, K. C. S., Prokopiuk, A. S., Swanson, R. A., and Souza, D. O. (2001). Activation of glutamate uptake by guanosine in primary astrocyte cultures. Neuroreport 12:879-881.
8. Lowry, O. H., Rosebrough, N. H., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
9. Maragakis, N. J., and Rothstein, J. D. (2001). Glutamate transporters in neurologic disease. Arch. Neurol. 58:365-370.
10. Pena, F., and Tapia, R. (2000). Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: Role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience 101(3):547-561.
11. kB. Mol. Pharmacol. 57:667-678.