메뉴 건너뛰기




Volumn 44, Issue 10, 2012, Pages 741-748

Protein kinase A alterations in endocrine tumors

Author keywords

adrenal tumors; cAMP; pituitary tumors; PKA

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; BETA CATENIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IIALPHA; CYCLIN B; CYCLIN D1; MESSENGER RNA; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA;

EID: 84866088983     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1316292     Document Type: Review
Times cited : (34)

References (75)
  • 1
    • 77949538387 scopus 로고    scopus 로고
    • Epac: Defining a new mechanism for cAMP action
    • Gloerich M, Bos J L. Epac: defining a new mechanism for cAMP action. Annu Rev Pharmacol Toxicol: 2010; 50 355 375
    • (2010) Annu Rev Pharmacol Toxicol , vol.50 , pp. 355-375
    • Gloerich, M.1    Bos, J.L.2
  • 2
    • 0016430836 scopus 로고
    • The distribution and dissociation of cyclic adenosine 3:5-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues
    • Corbin J D, Keely S L, Park C R. The distribution and dissociation of cyclic adenosine 3:5-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J Biol Chem: 1975; 250 218 225
    • (1975) J Biol Chem , vol.250 , pp. 218-225
    • Corbin, J.D.1    Keely, S.L.2    Park, C.R.3
  • 4
    • 0035413602 scopus 로고    scopus 로고
    • Physiological substrates of cAMP-dependent protein kinase
    • Shabb J B. Physiological substrates of cAMP-dependent protein kinase. Chem Rev: 2001; 101 2381 2411
    • (2001) Chem Rev , vol.101 , pp. 2381-2411
    • Shabb, J.B.1
  • 5
    • 0024404145 scopus 로고
    • GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours
    • Landis C A, Masters S B, Spada A, Pace A M, Bourne H R, Vallar L. GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature: 1989; 340 692 696
    • (1989) Nature , vol.340 , pp. 692-696
    • Landis, C.A.1    Masters, S.B.2    Spada, A.3    Pace, A.M.4    Bourne, H.R.5    Vallar, L.6
  • 7
    • 0028880502 scopus 로고
    • Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas
    • Porcellini A, Ciullo I, Pannain S, Fenzi G, Avvedimento E. Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas. Oncogene: 1995; 11 1089 1093
    • (1995) Oncogene , vol.11 , pp. 1089-1093
    • Porcellini, A.1    Ciullo, I.2    Pannain, S.3    Fenzi, G.4    Avvedimento, E.5
  • 8
    • 39049101528 scopus 로고    scopus 로고
    • Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia
    • Horvath A, Mericq V, Stratakis C A. Mutation in PDE8B, a cyclic AMP-specific phosphodiesterase in adrenal hyperplasia. N Engl J Med: 2008; 358 750 752
    • (2008) N Engl J Med , vol.358 , pp. 750-752
    • Horvath, A.1    Mericq, V.2    Stratakis, C.A.3
  • 10
    • 0017327456 scopus 로고
    • Adenosine 35-cyclic monophosphate dependent protein kinase in human adrenocortical tumors
    • Riou J P, Evain D, Perrin F, Saez J M. Adenosine 35-cyclic monophosphate dependent protein kinase in human adrenocortical tumors. J Clin Endocrinol Metab: 1977; 44 413 419
    • (1977) J Clin Endocrinol Metab , vol.44 , pp. 413-419
    • Riou, J.P.1    Evain, D.2    Perrin, F.3    Saez, J.M.4
  • 20
    • 1342325388 scopus 로고    scopus 로고
    • CAMP-dependent protein kinase regulatory subunit type IIbeta: Active site mutations define an isoform-specific network for allosteric signaling by cAMP
    • Zawadzki K M, Taylor S S. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. J Biol Chem: 2004; 279 7029 7036
    • (2004) J Biol Chem , vol.279 , pp. 7029-7036
    • Zawadzki, K.M.1    Taylor, S.S.2
  • 21
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex
    • Kirschner L S, Sandrini F, Monbo J, Lin J P, Carney J A, Stratakis C A. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the carney complex. Hum Mol Genet: 2000; 9 3037 3046
    • (2000) Hum Mol Genet , vol.9 , pp. 3037-3046
    • Kirschner, L.S.1    Sandrini, F.2    Monbo, J.3    Lin, J.P.4    Carney, J.A.5    Stratakis, C.A.6
  • 23
    • 0037331680 scopus 로고    scopus 로고
    • Clinical and molecular genetics of Carney complex
    • Sandrini F, Stratakis C. Clinical and molecular genetics of Carney complex. Mol Genet Metab: 2003; 78 83 92
    • (2003) Mol Genet Metab , vol.78 , pp. 83-92
    • Sandrini, F.1    Stratakis, C.2
  • 24
    • 39149133729 scopus 로고    scopus 로고
    • In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay
    • Greene E L, Horvath A D, Nesterova M, Giatzakis C, Bossis I, Stratakis C A. In vitro functional studies of naturally occurring pathogenic PRKAR1A mutations that are not subject to nonsense mRNA decay. Hum Mutat: 2008; 29 633 639
    • (2008) Hum Mutat , vol.29 , pp. 633-639
    • Greene, E.L.1    Horvath, A.D.2    Nesterova, M.3    Giatzakis, C.4    Bossis, I.5    Stratakis, C.A.6
  • 26
    • 0036907704 scopus 로고    scopus 로고
    • Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: Augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD
    • Groussin L, Kirschner L S, Vincent-Dejean C, Perlemoine K, Jullian E, Delemer B, Zacharieva S, Pignatelli D, Carney J A, Luton J P, Bertagna X, Stratakis C A, Bertherat J. Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD. Am J Hum Genet: 2002; 71 1433 1442
    • (2002) Am J Hum Genet , vol.71 , pp. 1433-1442
    • Groussin, L.1    Kirschner, L.S.2    Vincent-Dejean, C.3    Perlemoine, K.4    Jullian, E.5    Delemer, B.6    Zacharieva, S.7    Pignatelli, D.8    Carney, J.A.9    Luton, J.P.10    Bertagna, X.11    Stratakis, C.A.12    Bertherat, J.13
  • 29
    • 84858054011 scopus 로고    scopus 로고
    • In Vitro Studies of Novel PRKAR1A Mutants that Extend the Predicted RIalpha Protein Sequence into the 3'-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RIalpha Haploinsufficiency and Carney Complex
    • Patronas Y, Horvath A, Greene E, Tsang K, Bimpaki E, Haran M, Nesterova M, Stratakis C A. In Vitro Studies of Novel PRKAR1A Mutants that Extend the Predicted RIalpha Protein Sequence into the 3'-Untranslated Open Reading Frame: Proteasomal Degradation Leads to RIalpha Haploinsufficiency and Carney Complex. J Clin Endocrinol Metab: 2012; 97 E496 E502
    • (2012) J Clin Endocrinol Metab , vol.97
    • Patronas, Y.1    Horvath, A.2    Greene, E.3    Tsang, K.4    Bimpaki, E.5    Haran, M.6    Nesterova, M.7    Stratakis, C.A.8
  • 33
    • 77955324701 scopus 로고    scopus 로고
    • PRKAR1A and the evolution of pituitary tumors
    • Kirschner LS. PRKAR1A and the evolution of pituitary tumors. Mol Cell Endocrinol: 2010; 326 3 7
    • (2010) Mol Cell Endocrinol , vol.326 , pp. 3-7
    • Kirschner, L.S.1
  • 34
    • 63149085063 scopus 로고    scopus 로고
    • Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a PRKAR1A mutation
    • Takano K, Yasufuku-Takano J, Morita K, Mori S, Takei M, Osamura R Y, Teramoto A, Fujita T. Evidence that PKA activity is constitutively activated in human GH-secreting adenoma cells in a patient with Carney complex harbouring a PRKAR1A mutation. Clin Endocrinol (Oxf): 2009; 70 769 775
    • (2009) Clin Endocrinol (Oxf) , vol.70 , pp. 769-775
    • Takano, K.1    Yasufuku-Takano, J.2    Morita, K.3    Mori, S.4    Takei, M.5    Osamura, R.Y.6    Teramoto, A.7    Fujita, T.8
  • 39
    • 0027456590 scopus 로고
    • 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells
    • Rohlff C, Clair T, Cho-Chung Y S. 8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem: 1993; 268 5774 5782
    • (1993) J Biol Chem , vol.268 , pp. 5774-5782
    • Rohlff, C.1    Clair, T.2    Cho-Chung, Y.S.3
  • 40
    • 9444247656 scopus 로고    scopus 로고
    • Minireview: PRKAR1A: Normal and abnormal functions
    • Bossis I, Stratakis C A. Minireview: PRKAR1A: normal and abnormal functions. Endocrinology: 2004; 145 5452 5458
    • (2004) Endocrinology , vol.145 , pp. 5452-5458
    • Bossis, I.1    Stratakis, C.A.2
  • 41
    • 9944245504 scopus 로고    scopus 로고
    • Protein kinase A isozyme switching: Eliciting differential cAMP signaling and tumor reversion
    • Neary C L, Nesterova M, Cho Y S, Cheadle C, Becker K G, Cho-Chung Y S. Protein kinase A isozyme switching: eliciting differential cAMP signaling and tumor reversion. Oncogene: 2004; 23 8847 8856
    • (2004) Oncogene , vol.23 , pp. 8847-8856
    • Neary, C.L.1    Nesterova, M.2    Cho, Y.S.3    Cheadle, C.4    Becker, K.G.5    Cho-Chung, Y.S.6
  • 43
    • 44949097324 scopus 로고    scopus 로고
    • Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity
    • Vincent-Dejean C, Cazabat L, Groussin L, Perlemoine K, Fumey G, Tissier F, Bertagna X, Bertherat J. Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity. Eur J Endocrinol: 2008; 158 829 839
    • (2008) Eur J Endocrinol , vol.158 , pp. 829-839
    • Vincent-Dejean, C.1    Cazabat, L.2    Groussin, L.3    Perlemoine, K.4    Fumey, G.5    Tissier, F.6    Bertagna, X.7    Bertherat, J.8
  • 45
    • 79959989285 scopus 로고    scopus 로고
    • An intimate connection between ubiquitination and compartmentalized cAMP signaling
    • Lignitto L, Sepe M, Carlucci A, Feliciello A. An intimate connection between ubiquitination and compartmentalized cAMP signaling. Cell Cycle: 2011; 10 2051 2052
    • (2011) Cell Cycle , vol.10 , pp. 2051-2052
    • Lignitto, L.1    Sepe, M.2    Carlucci, A.3    Feliciello, A.4
  • 46
    • 80053450655 scopus 로고    scopus 로고
    • Differential role of PKA catalytic subunits in mediating phenotypes caused by knockout of the carney complex gene prkar1a
    • Yin Z, Pringle D R, Jones G N, Kelly K M, Kirschner L S. Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a. Mol Endocrinol: 2011; 25 1786 1793
    • (2011) Mol Endocrinol , vol.25 , pp. 1786-1793
    • Yin, Z.1    Pringle, D.R.2    Jones, G.N.3    Kelly, K.M.4    Kirschner, L.S.5
  • 47
    • 0037178847 scopus 로고    scopus 로고
    • Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo
    • Amieux P S, Howe D G, Knickerbocker H, Lee D C, Su T, Laszlo G S, Idzerda R L, McKnight G S. Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem: 2002; 277 27294 27304
    • (2002) J Biol Chem , vol.277 , pp. 27294-27304
    • Amieux, P.S.1    Howe, D.G.2    Knickerbocker, H.3    Lee, D.C.4    Su, T.5    Laszlo, G.S.6    Idzerda, R.L.7    McKnight, G.S.8
  • 50
    • 38749106141 scopus 로고    scopus 로고
    • Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis
    • Yin Z, Williams-Simons L, Parlow A F, Asa S, Kirschner L S. Pituitary-specific knockout of the Carney complex gene Prkar1a leads to pituitary tumorigenesis. Mol Endocrinol: 2008; 22 380 387
    • (2008) Mol Endocrinol , vol.22 , pp. 380-387
    • Yin, Z.1    Williams-Simons, L.2    Parlow, A.F.3    Asa, S.4    Kirschner, L.S.5
  • 52
    • 28544445921 scopus 로고    scopus 로고
    • Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins
    • Nadella K S, Kirschner L S. Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins. Cancer Res: 2005; 65 10307 10315
    • (2005) Cancer Res , vol.65 , pp. 10307-10315
    • Nadella, K.S.1    Kirschner, L.S.2
  • 58
    • 0027499174 scopus 로고
    • An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells
    • Yokozaki H, Budillon A, Tortora G, Meissner S, Beaucage S L, Miki K, Cho-Chung Y S. An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells. Cancer Res: 1993; 53 868 872
    • (1993) Cancer Res , vol.53 , pp. 868-872
    • Yokozaki, H.1    Budillon, A.2    Tortora, G.3    Meissner, S.4    Beaucage, S.L.5    Miki, K.6    Cho-Chung, Y.S.7
  • 59
    • 0038105075 scopus 로고    scopus 로고
    • Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2
    • Robinson-White A, Hundley T R, Shiferaw M, Bertherat J, Sandrini F, Stratakis C A. Protein kinase-A activity in PRKAR1A-mutant cells, and regulation of mitogen-activated protein kinases ERK1/2. Hum Mol Genet: 2003; 12 1475 1484
    • (2003) Hum Mol Genet , vol.12 , pp. 1475-1484
    • Robinson-White, A.1    Hundley, T.R.2    Shiferaw, M.3    Bertherat, J.4    Sandrini, F.5    Stratakis, C.A.6
  • 61
    • 70349742485 scopus 로고    scopus 로고
    • Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells
    • Ragazzon B, Cazabat L, Rizk-Rabin M, Assie G, Groussin L, Fierrard H, Perlemoine K, Martinez A, Bertherat J. Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells. Cancer Res: 2009; 69 7278 7284
    • (2009) Cancer Res , vol.69 , pp. 7278-7284
    • Ragazzon, B.1    Cazabat, L.2    Rizk-Rabin, M.3    Assie, G.4    Groussin, L.5    Fierrard, H.6    Perlemoine, K.7    Martinez, A.8    Bertherat, J.9
  • 62
    • 77952775652 scopus 로고    scopus 로고
    • 8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells
    • Bouizar Z, Ragazzon B, Viou L, Hortane M, Bertherat J, Rizk-Rabin M. 8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells. J Mol Endocrinol: 2010; 44 331 347
    • (2010) J Mol Endocrinol , vol.44 , pp. 331-347
    • Bouizar, Z.1    Ragazzon, B.2    Viou, L.3    Hortane, M.4    Bertherat, J.5    Rizk-Rabin, M.6
  • 63
    • 0035516189 scopus 로고    scopus 로고
    • Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice
    • Schreyer S A, Cummings D E, McKnight G S, LeBoeuf R C. Mutation of the RIIbeta subunit of protein kinase A prevents diet-induced insulin resistance and dyslipidemia in mice. Diabetes: 2001; 50 2555 2562
    • (2001) Diabetes , vol.50 , pp. 2555-2562
    • Schreyer, S.A.1    Cummings, D.E.2    McKnight, G.S.3    Leboeuf, R.C.4
  • 65
    • 67349101630 scopus 로고    scopus 로고
    • Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1
    • Nadella K S, Saji M, Jacob N K, Pavel E, Ringel M D, Kirschner L S. Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1. EMBO Rep: 2009; 10 599 605
    • (2009) EMBO Rep , vol.10 , pp. 599-605
    • Nadella, K.S.1    Saji, M.2    Jacob, N.K.3    Pavel, E.4    Ringel, M.D.5    Kirschner, L.S.6
  • 66
    • 0036710928 scopus 로고    scopus 로고
    • Lipofuscin: Mechanisms of age-related accumulation and influence on cell function
    • Brunk U T, Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell function. Free Radic Biol Med: 2002; 33 611 619
    • (2002) Free Radic Biol Med , vol.33 , pp. 611-619
    • Brunk, U.T.1    Terman, A.2
  • 67
    • 33749000851 scopus 로고    scopus 로고
    • Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency
    • Mavrakis M, Lippincott-Schwartz J, Stratakis C A, Bossis I. Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency. Hum Mol Genet: 2006; 15 2962 2971
    • (2006) Hum Mol Genet , vol.15 , pp. 2962-2971
    • Mavrakis, M.1    Lippincott-Schwartz, J.2    Stratakis, C.A.3    Bossis, I.4
  • 68
    • 42349115928 scopus 로고    scopus 로고
    • Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition
    • Nadella K S, Jones G N, Trimboli A, Stratakis C A, Leone G, Kirschner L S. Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition. Cancer Res: 2008; 68 2671 2677
    • (2008) Cancer Res , vol.68 , pp. 2671-2677
    • Nadella, K.S.1    Jones, G.N.2    Trimboli, A.3    Stratakis, C.A.4    Leone, G.5    Kirschner, L.S.6
  • 69
    • 49649127949 scopus 로고    scopus 로고
    • Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
    • Tadjine M, Lampron A, Ouadi L, Horvath A, Stratakis C A, Bourdeau I. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). Clin Endocrinol (Oxf): 2008; 69 367 373
    • (2008) Clin Endocrinol (Oxf) , vol.69 , pp. 367-373
    • Tadjine, M.1    Lampron, A.2    Ouadi, L.3    Horvath, A.4    Stratakis, C.A.5    Bourdeau, I.6
  • 70
    • 70350321017 scopus 로고    scopus 로고
    • Convergence of 3,5-cyclic adenosine 5-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis
    • Roy L, McDonald C A, Jiang C, Maroni D, Zeleznik A J, Wyatt T A, Hou X, Davis J S. Convergence of 3,5-cyclic adenosine 5-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis. Endocrinology: 2009; 150 5036 5045
    • (2009) Endocrinology , vol.150 , pp. 5036-5045
    • Roy, L.1    McDonald, C.A.2    Jiang, C.3    Maroni, D.4    Zeleznik, A.J.5    Wyatt, T.A.6    Hou, X.7    Davis, J.S.8
  • 71
    • 1542741588 scopus 로고    scopus 로고
    • Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators
    • Bourdeau I, Antonini S R, Lacroix A, Kirschner L S, Matyakhina L, Lorang D, Libutti S K, Stratakis C A. Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators. Oncogene: 2004; 23 1575 1585
    • (2004) Oncogene , vol.23 , pp. 1575-1585
    • Bourdeau, I.1    Antonini, S.R.2    Lacroix, A.3    Kirschner, L.S.4    Matyakhina, L.5    Lorang, D.6    Libutti, S.K.7    Stratakis, C.A.8
  • 72
    • 53749096474 scopus 로고    scopus 로고
    • Wnt/beta-catenin and 3,5-cyclic adenosine 5-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors
    • Gaujoux S, Tissier F, Groussin L, Libe R, Ragazzon B, Launay P, Audebourg A, Dousset B, Bertagna X, Bertherat J. Wnt/beta-catenin and 3,5-cyclic adenosine 5-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors. J Clin Endocrinol Metab: 2008; 93 4135 4140
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4135-4140
    • Gaujoux, S.1    Tissier, F.2    Groussin, L.3    Libe, R.4    Ragazzon, B.5    Launay, P.6    Audebourg, A.7    Dousset, B.8    Bertagna, X.9    Bertherat, J.10
  • 73
    • 65949092330 scopus 로고    scopus 로고
    • MicroRNA signature of primary pigmented nodular adrenocortical disease: Clinical correlations and regulation of Wnt signaling
    • Iliopoulos D, Bimpaki E I, Nesterova M, Stratakis C A. MicroRNA signature of primary pigmented nodular adrenocortical disease: clinical correlations and regulation of Wnt signaling. Cancer Res: 2009; 69 3278 3282
    • (2009) Cancer Res , vol.69 , pp. 3278-3282
    • Iliopoulos, D.1    Bimpaki, E.I.2    Nesterova, M.3    Stratakis, C.A.4
  • 75
    • 70349898599 scopus 로고    scopus 로고
    • 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: Implications for treatment of Carney complex-associated tumors
    • Robinson-White A J, Bossis I, Hsiao H P, Nesterova M, Leitner W W, Stratakis C A. 8-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: implications for treatment of Carney complex-associated tumors. J Clin Endocrinol Metab: 2009; 94 4061 4069
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 4061-4069
    • Robinson-White, A.J.1    Bossis, I.2    Hsiao, H.P.3    Nesterova, M.4    Leitner, W.W.5    Stratakis, C.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.