Effect of cyclic adenosine 3′,5′-monophosphate/protein kinase A pathway on markers of cell proliferation in nonfunctioning pituitary adenomas

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 12, 2005, Pages 6721-6724

  Mantovani, G ^a   Bondioni, S ^a   Ferrero, S ^a   Gamba, B ^a   Ferrante, E ^a   Peverelli, E ^a   Corbetta, S ^a   Locatelli, M ^a   Rampini, P ^a   Beck Peccoz, P ^a   Spada, A ^a,b   Lania, A G ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Institute of Dermatological Sciences   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLOROADENOSINE 3',5' PHOSPHATE; ADENYLATE CYCLASE; BIOLOGICAL MARKER; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLIN D1; FORSKOLIN; GONADOTROPIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN DERIVATIVE; PROTEIN KINASE A REGULATORY SUBUNIT 1A; PROTEIN KINASE A REGULATORY SUBUNIT 2A; PROTEIN KINASE A REGULATORY SUBUNIT 2B; UNCLASSIFIED DRUG;

ARTICLE; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GONADOTROPIN SECRETING CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS ADENOMA; IMMUNOHISTOCHEMISTRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SOMATIC CELL;

ADENOMA; BASE SEQUENCE; CELL PROLIFERATION; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIN D1; ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PITUITARY NEOPLASMS; PROTEINS; RECEPTORS, CELL SURFACE; TUMOR MARKERS, BIOLOGICAL;

EID: 28744433844     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-0977     Document Type: Article

References (16)

1. Lania A, Mantovani G, Spada A 2001 G protein mutations in endocrine diseases. Eur J Endocrinol 145:543-559
2. Kalhegg BS, Tasken K 2000 Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Front Biosci 5:D678-D693
3. Kirschner LS, Sandrini F, Monbo J, Lin JP, Carney JA, Stratakis CA 2000 Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum Mol Genet 9:3037-3046
4. Lania A, Mantovani G, Ferrero S, Pellegrini C, Bondioni S, Peverelli E, Braidotti P, Locatelli M, Zavanone M, Ferrante E, Bosari S, Beck-Peccoz P, Spada A 2004 Proliferation of transformed somatotroph cells related to low or absent expression of PKA regulatory subunit 1A protein. Cancer Res 64:9193-9198
5. Marinissen MJ, Gutkind JS 2001 G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 22:368-376
6. Naor Z, Benard O, Seger R 2000 Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. Trends Endocrinol Metab 11:91-99
7. Lania A, Filopanti M, Corbetta S, Losa M, Ballare E, Beck-Peccoz P, Spada A 2003 Effects of hypothalamic neuropeptides on extracellular signal-regulated kinase (ERK1 and ERK2) cascade in human tumoral pituitary cells. J Clin Endocrinol Metab 88:1692-1696
8. Bassetti M, Spada A, Arosio M, Vallar L, Brina M, Giannattasio G 1986 Morphological studies on mixed growth hormone (GH) and prolactin (PRL)-secreting adenomas. Coexistence of GH and PRL in the same secretory granules. J Clin Endocrinol Metab 418:405-410
9. sα is associated with an increased phosphodiesterase activity in human growth hormone secreting adenomas. J Clin Endocrinol Metab 83:1624-1628
10. sα gene in human bone and adipose tissue. J Clin Endocrinol Metab 89:6316-6319
11. Yamasaki H, Mizusawa N, Nagahiro S, Yamada S, Sano T, Itakura M, Yoshimoto K 2003 GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24. Clin Endocrinol (Oxf) 58:464-470
12. Stork PJ, Schmitt JM 2002 Crosstalk between cAMP andMAPkinase signaling in the regulation of cell proliferation. Trends Cell Biol 12:258-266
13. Jordan S, Lidhar K, Korbonits M, Lowe DG, Grossman AB 2000 cyclin D and cyclin E expression in normal and adenomatous pituitary. Eur J Endocrinol 143:1-6
14. Reiss N, Llevi LN, Shacham S, Harris D, Seger R, Naor Z 1997 Mechanism of mitogen-activated protein kinase activation by gonadotropin-releasing hormone in the pituitary of αT3-1 cell line: differential roles of calcium and protein kinase C. Endocrinology 138:1673-1682
15. Melmed S 2003 Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112:1603-1618
16. Farrell WE, Clayton RN 2003 Epigenetic change in pituitary tumorigenesis. Endocr Relat Cancer 10:323-330