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Volumn 68, Issue 8, 2008, Pages 2671-2677

Targeted deletion of Prkar1a reveals a role for protein kinase A in mesenchymal-to-epithelial transition

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ALPHA SMOOTH MUSCLE ACTIN; BETA GALACTOSIDASE; BIOCHEMICAL MARKER; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRONECTIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE CELL ADHESION MOLECULE; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UVOMORULIN; VIMENTIN;

EID: 42349115928     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6002     Document Type: Article
Times cited : (32)

References (43)
  • 1
    • 0029737861 scopus 로고    scopus 로고
    • Genetically lean mice result from targeted disruption of the RII β subunit of protein kinase A
    • Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL, McKnight GS. Genetically lean mice result from targeted disruption of the RII β subunit of protein kinase A. Nature 1996;382:622-6.
    • (1996) Nature , vol.382 , pp. 622-626
    • Cummings, D.E.1    Brandon, E.P.2    Planas, J.V.3    Motamed, K.4    Idzerda, R.L.5    McKnight, G.S.6
  • 2
    • 0033587807 scopus 로고    scopus 로고
    • Deletion of type IIα regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization
    • Burton KA, Treash-Osio B, Muller CH, Dunphy EL, McKnight GS. Deletion of type IIα regulatory subunit delocalizes protein kinase A in mouse sperm without affecting motility or fertilization. J Biol Chem 1999;274: 24131-6.
    • (1999) J Biol Chem , vol.274 , pp. 24131-24136
    • Burton, K.A.1    Treash-Osio, B.2    Muller, C.H.3    Dunphy, E.L.4    McKnight, G.S.5
  • 3
    • 0037178847 scopus 로고    scopus 로고
    • Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo
    • Amieux PS, Howe DG, Knickerbocker H, et al. Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J Biol Chem 2002;277: 27294-304.
    • (2002) J Biol Chem , vol.277 , pp. 27294-27304
    • Amieux, P.S.1    Howe, D.G.2    Knickerbocker, H.3
  • 4
    • 0033812849 scopus 로고    scopus 로고
    • Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex
    • Kirschner LS, Carney JA, Pack SD, et al. Mutations of the gene encoding the protein kinase A type I-α regulatory subunit in patients with the Carney complex. Nat Genet 2000;26:89-92.
    • (2000) Nat Genet , vol.26 , pp. 89-92
    • Kirschner, L.S.1    Carney, J.A.2    Pack, S.D.3
  • 5
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex
    • Kirschner LS, Sandrini F, Monbo J, Lin JP, Carney JA, Stratakis CA. Genetic heterogeneity and spectrum of mutations of the PRKAR1A gene in patients with the Carney complex. Hum Mol Genet 2000;9:3037-46.
    • (2000) Hum Mol Genet , vol.9 , pp. 3037-3046
    • Kirschner, L.S.1    Sandrini, F.2    Monbo, J.3    Lin, J.P.4    Carney, J.A.5    Stratakis, C.A.6
  • 6
    • 18544406892 scopus 로고    scopus 로고
    • Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex
    • Casey M, Vaughan CJ, He J, et al. Mutations in the protein kinase A R1α regulatory subunit cause familial cardiac myxomas and Carney complex. J Clin Invest 2000;106:R31-8.
    • (2000) J Clin Invest , vol.106
    • Casey, M.1    Vaughan, C.J.2    He, J.3
  • 7
    • 0038721027 scopus 로고    scopus 로고
    • Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity
    • Bertherat J, Groussin L, Sandrini F, et al. Molecular and functional analysis of PRKAR1A and its locus (17q22-24) in sporadic adrenocortical tumors: 17q losses, somatic mutations, and protein kinase A expression and activity. Cancer Res 2003;63:5308-19.
    • (2003) Cancer Res , vol.63 , pp. 5308-5319
    • Bertherat, J.1    Groussin, L.2    Sandrini, F.3
  • 8
    • 0036778647 scopus 로고    scopus 로고
    • Regulatory subunit type I-α of protein kinase A (PRKAR1A): A tumor-suppressor gene for sporadic thyroid cancer
    • Sandrini F, Matyakhina L, Sarlis NJ, et al. Regulatory subunit type I-α of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer. Genes Chromosomes Cancer 2002;35:182-92.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 182-192
    • Sandrini, F.1    Matyakhina, L.2    Sarlis, N.J.3
  • 9
    • 19644364776 scopus 로고    scopus 로고
    • A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues
    • Kirschner LS, Kusewitt DF, Matyakhina L, et al. A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Cancer Res 2005;65:4506-44.
    • (2005) Cancer Res , vol.65 , pp. 4506-4544
    • Kirschner, L.S.1    Kusewitt, D.F.2    Matyakhina, L.3
  • 10
    • 0023228288 scopus 로고    scopus 로고
    • Goldman BI, Frydman C, Harpaz N, Ryan SF, Loiterman D. Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation. Cancer 1987;59:1767-75.
    • Goldman BI, Frydman C, Harpaz N, Ryan SF, Loiterman D. Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation. Cancer 1987;59:1767-75.
  • 11
    • 0025371817 scopus 로고
    • The role of the vimentin intermediate filaments in rat 3Y1 cells elucidated by immunoelectron microscopy and computer-graphic reconstruction
    • Katsumoto T, Mitsushima A, Kurimura T. The role of the vimentin intermediate filaments in rat 3Y1 cells elucidated by immunoelectron microscopy and computer-graphic reconstruction. Biol Cell 1990;68: 139-46.
    • (1990) Biol Cell , vol.68 , pp. 139-146
    • Katsumoto, T.1    Mitsushima, A.2    Kurimura, T.3
  • 12
    • 0345689420 scopus 로고    scopus 로고
    • Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues
    • Tonks ID, Nurcombe V, Paterson C, et al. Tyrosinase-Cre mice for tissue-specific gene ablation in neural crest and neuroepithelial-derived tissues. Genesis 2003;37: 131-8.
    • (2003) Genesis , vol.37 , pp. 131-138
    • Tonks, I.D.1    Nurcombe, V.2    Paterson, C.3
  • 14
    • 28544445921 scopus 로고    scopus 로고
    • Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins
    • Nadella KS, Kirschner LS. Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins. Cancer Res 2005;65: 10307-15.
    • (2005) Cancer Res , vol.65 , pp. 10307-10315
    • Nadella, K.S.1    Kirschner, L.S.2
  • 15
    • 38749151856 scopus 로고    scopus 로고
    • Mutation of Prkar1a Causes Osteoblast Neoplasia Driven by Dysregulation of PKA
    • Epub Oct 11
    • Pavel E, Nadella K, Towns WH II, Kirschner LS. Mutation of Prkar1a Causes Osteoblast Neoplasia Driven by Dysregulation of PKA. Mol Endocrinol 2007. Epub 2007 Oct 11.
    • (2007) Mol Endocrinol 2007
    • Pavel, E.1    Nadella, K.2    Towns II, W.H.3    Kirschner, L.S.4
  • 16
    • 0032923739 scopus 로고    scopus 로고
    • Generalized lacZ expression with the ROSA26 Cre reporter strain
    • Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999;21:70-1.
    • (1999) Nat Genet , vol.21 , pp. 70-71
    • Soriano, P.1
  • 17
    • 33846819015 scopus 로고    scopus 로고
    • Transcriptional regulation of epithelial-mesenchymal transition
    • Teng Y, Zeisberg M, Kalluri R. Transcriptional regulation of epithelial-mesenchymal transition. J Clin Invest 2007;117:304-6.
    • (2007) J Clin Invest , vol.117 , pp. 304-306
    • Teng, Y.1    Zeisberg, M.2    Kalluri, R.3
  • 18
    • 0034853288 scopus 로고    scopus 로고
    • Clinical and molecular features of the Carney complex: Diagnostic criteria and recommendations for patient evaluation
    • Stratakis CA, Kirschner LS, Carney JA. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab 2001;86:4041-6.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4041-4046
    • Stratakis, C.A.1    Kirschner, L.S.2    Carney, J.A.3
  • 19
    • 0036736814 scopus 로고    scopus 로고
    • Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease
    • Groussin L, Jullian E, Perlemoine K, et al. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. J Clin Endocrinol Metab 2002;87:4324-9.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 4324-4329
    • Groussin, L.1    Jullian, E.2    Perlemoine, K.3
  • 20
    • 33749000851 scopus 로고    scopus 로고
    • Depletion of type IA regulatory subunit (RIα) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency
    • Mavrakis M, Lippincott-Schwartz J, Stratakis CA, Bossis I. Depletion of type IA regulatory subunit (RIα) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency. Hum Mol Genet 2006;15:2962-71.
    • (2006) Hum Mol Genet , vol.15 , pp. 2962-2971
    • Mavrakis, M.1    Lippincott-Schwartz, J.2    Stratakis, C.A.3    Bossis, I.4
  • 21
    • 10844257526 scopus 로고    scopus 로고
    • Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors
    • Griffin KJ, Kirschner LS, Matyakhina L, et al. Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors. Cancer Res 2004;64:8811-5.
    • (2004) Cancer Res , vol.64 , pp. 8811-8815
    • Griffin, K.J.1    Kirschner, L.S.2    Matyakhina, L.3
  • 22
    • 4644277913 scopus 로고    scopus 로고
    • Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice
    • Veugelers M, Wilkes D, Burton K, et al. Comparative PRKAR1A genotype-phenotype analyses in humans with Carney complex and prkar1a haploinsufficient mice. Proc Natl Acad Sci U S A 2004;101:14222-7.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 14222-14227
    • Veugelers, M.1    Wilkes, D.2    Burton, K.3
  • 23
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial- mesenchymal transitions
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial- mesenchymal transitions. Nat Rev Mol Cell Biol 2006;7:131-42.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 24
    • 33847298591 scopus 로고    scopus 로고
    • Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion
    • Vasko V, Espinosa AV, Scouten W, et al. Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion. Proc Natl Acad Sci U S A 2007;104: 2803-8.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 2803-2808
    • Vasko, V.1    Espinosa, A.V.2    Scouten, W.3
  • 25
    • 0028970302 scopus 로고
    • Early stages of chick somite development
    • Christ B, Ordahl CP. Early stages of chick somite development. Anat Embryol (Berl) 1995;191:381-96.
    • (1995) Anat Embryol (Berl) , vol.191 , pp. 381-396
    • Christ, B.1    Ordahl, C.P.2
  • 26
    • 0032857529 scopus 로고    scopus 로고
    • Coelom formation: Binary decision of the lateral plate mesoderm is controlled by the ectoderm
    • Funayama N, Sato Y, Matsumoto K, Ogura T, Takahashi Y. Coelom formation: binary decision of the lateral plate mesoderm is controlled by the ectoderm. Development 1999;126:4129-38.
    • (1999) Development , vol.126 , pp. 4129-4138
    • Funayama, N.1    Sato, Y.2    Matsumoto, K.3    Ogura, T.4    Takahashi, Y.5
  • 27
    • 0035427394 scopus 로고    scopus 로고
    • Cell movements during vertebrate development: Integrated tissue behaviour versus individual cell migration
    • Locascio A, Nieto MA. Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration. Curr Opin Genet Dev 2001;11:464-9.
    • (2001) Curr Opin Genet Dev , vol.11 , pp. 464-469
    • Locascio, A.1    Nieto, M.A.2
  • 28
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • Nieto MA. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 2002;3: 155-66.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 29
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
    • Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED. Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res 2006;66:11271-8.
    • (2006) Cancer Res , vol.66 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5    Williams, E.D.6
  • 30
    • 0032991804 scopus 로고    scopus 로고
    • E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium
    • Auersperg N, Pan J, Grove BD, et al. E-cadherin induces mesenchymal-to-epithelial transition in human ovarian surface epithelium. Proc Natl Acad Sci U S A 1999;96:6249-54.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 6249-6254
    • Auersperg, N.1    Pan, J.2    Grove, B.D.3
  • 31
    • 33745395808 scopus 로고    scopus 로고
    • Versican mediates mesenchymal-epithelial transition
    • Sheng W, Wang G, La Pierre DP, et al. Versican mediates mesenchymal-epithelial transition. Mol Biol Cell 2006;17:2009-20.
    • (2006) Mol Biol Cell , vol.17 , pp. 2009-2020
    • Sheng, W.1    Wang, G.2    La Pierre, D.P.3
  • 32
    • 33749004556 scopus 로고    scopus 로고
    • Regulation of transforming growth factor-{β}1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3
    • Yang Y, Pan X, Lei W, et al. Regulation of transforming growth factor-{β}1-induced apoptosis and epithelial-to-mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer Res 2006;66:8617-24.
    • (2006) Cancer Res , vol.66 , pp. 8617-8624
    • Yang, Y.1    Pan, X.2    Lei, W.3
  • 33
    • 33646137784 scopus 로고    scopus 로고
    • Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
    • Sakai D, Suzuki T, Osumi N, Wakamatsu Y. Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development. Development 2006; 133:1323-33.
    • (2006) Development , vol.133 , pp. 1323-1333
    • Sakai, D.1    Suzuki, T.2    Osumi, N.3    Wakamatsu, Y.4
  • 34
    • 0024328163 scopus 로고
    • Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase
    • Lamb NJ, Fernandez A, Feramisco JR, Welch WJ. Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase. J Cell Biol 1989;108:2409-22.
    • (1989) J Cell Biol , vol.108 , pp. 2409-2422
    • Lamb, N.J.1    Fernandez, A.2    Feramisco, J.R.3    Welch, W.J.4
  • 35
    • 0023239962 scopus 로고
    • Site-specific phosphorylation induces disassembly of vimentin filaments in vitro
    • Inagaki M, Nishi Y, Nishizawa K, Matsuyama M, Sato C. Site-specific phosphorylation induces disassembly of vimentin filaments in vitro. Nature 1987;328: 649-52.
    • (1987) Nature , vol.328 , pp. 649-652
    • Inagaki, M.1    Nishi, Y.2    Nishizawa, K.3    Matsuyama, M.4    Sato, C.5
  • 36
    • 2142758644 scopus 로고    scopus 로고
    • Rab13 regulates PKA signaling during tight junction assembly
    • Kohler K, Louvard D, Zahraoui A. Rab13 regulates PKA signaling during tight junction assembly. J Cell Biol 2004;165:175-80.
    • (2004) J Cell Biol , vol.165 , pp. 175-180
    • Kohler, K.1    Louvard, D.2    Zahraoui, A.3
  • 37
    • 0023253287 scopus 로고
    • The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms. A comprehensive immunohistochemical study on formalin-and alcohol-fixed tumors
    • Azumi N, Battifora H. The distribution of vimentin and keratin in epithelial and nonepithelial neoplasms. A comprehensive immunohistochemical study on formalin-and alcohol-fixed tumors. Am J Clin Pathol 1987;88: 286-96.
    • (1987) Am J Clin Pathol , vol.88 , pp. 286-296
    • Azumi, N.1    Battifora, H.2
  • 39
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172:973-81.
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 40
    • 0030883247 scopus 로고    scopus 로고
    • Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: Implications for tumorigenesis
    • Reincke M, Mora P, Beuschlein F, Arlt W, Chrousos GP, Allolio B. Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: implications for tumorigenesis. J Clin Endocrinol Metab 1997; 82:3054-8.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3054-3058
    • Reincke, M.1    Mora, P.2    Beuschlein, F.3    Arlt, W.4    Chrousos, G.P.5    Allolio, B.6
  • 41
    • 0030791708 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase A is required for Schwann cell growth: Interactions between the cAMP and neuregulin/tyrosine kinase pathways
    • Kim HA, DeClue JE, Ratner N. cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways. J Neurosci Res 1997;49: 236-47.
    • (1997) J Neurosci Res , vol.49 , pp. 236-247
    • Kim, H.A.1    DeClue, J.E.2    Ratner, N.3
  • 42
    • 0022631190 scopus 로고
    • Schwann cell responses to cyclic AMP: Proliferation, change in shape, and appearance of surface galactocerebroside
    • Sobue G, Shuman S, Pleasure D. Schwann cell responses to cyclic AMP: proliferation, change in shape, and appearance of surface galactocerebroside. Brain Res 1986;362:23-32.
    • (1986) Brain Res , vol.362 , pp. 23-32
    • Sobue, G.1    Shuman, S.2    Pleasure, D.3
  • 43
    • 0037323839 scopus 로고    scopus 로고
    • A-kinase-anchoring proteins and cytoskeletal signalling events
    • Scott JD. A-kinase-anchoring proteins and cytoskeletal signalling events. Biochem Soc Trans 2003;31: 87-9.
    • (2003) Biochem Soc Trans , vol.31 , pp. 87-89
    • Scott, J.D.1


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