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Volumn 94, Issue 10, 2009, Pages 4061-4069

18-Cl-adenosine inhibits proliferation and causes apoptosis in B-lymphocytes via protein kinase A-dependent and independent effects: Implications for treatment of carney complex-associated tumors

Author keywords

[No Author keywords available]

Indexed keywords

8 CHLOROADENOSINE; ADENOSINE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DERIVATIVE; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; 8 BROMO CYCLIC AMP; 8 CHLORO CYCLIC ADENOSINE MONOPHOSPHATE; 8-CHLORO-CYCLIC ADENOSINE MONOPHOSPHATE; ANTINEOPLASTIC AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; DRUG DERIVATIVE; PRKAR1A PROTEIN, HUMAN;

EID: 70349898599     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0759     Document Type: Article
Times cited : (6)

References (40)
  • 1
    • 80051974356 scopus 로고
    • Primary pigmented nodular adrenocortical disease and its associated conditions
    • Carney JA, Young WF 1992 Primary pigmented nodular adrenocortical disease and its associated conditions. Endocrinology 2:6-21
    • (1992) Endocrinology , vol.2 , pp. 6-21
    • Carney, J.A.1    Young, W.F.2
  • 4
    • 0036291278 scopus 로고    scopus 로고
    • Mutations of the gene encoding the protein kinase A type I-α regulatory subunit (PRKARIA) in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas' (Carney complex)
    • Stratakis CA 2002 Mutations of the gene encoding the protein kinase A type I-α regulatory subunit (PRKARIA) in patients with the 'complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas' (Carney complex). Ann NY Acad Sci 968:3-21
    • (2002) Ann NY Acad Sci , vol.968 , pp. 3-21
    • Stratakis, C.A.1
  • 5
    • 0034642302 scopus 로고    scopus 로고
    • Genetic heterogeneity and spectrum of mutations of the PRKARIA gene in patients with the Carney complex
    • Kirschner LS, Sandrini F, Monbo J, Lin P, Carney JA, Stratakis CA 2000 Genetic heterogeneity and spectrum of mutations of the PRKARIA gene in patients with the Carney complex. Hum Mol Genet 9:3037-3046
    • (2000) Hum Mol Genet , vol.9 , pp. 3037-3046
    • Kirschner, L.S.1    Sandrini, F.2    Monbo, J.3    Lin, P.4    Carney, J.A.5    Stratakis, C.A.6
  • 12
    • 0025810398 scopus 로고
    • Cyclic nucleotide-dependent protein kinases
    • Scott JD 1991 Cyclic nucleotide-dependent protein kinases. Pharmacol Ther 50:123-145
    • (1991) Pharmacol Ther , vol.50 , pp. 123-145
    • Scott, J.D.1
  • 13
    • 0036293732 scopus 로고    scopus 로고
    • Protein kinase A signaling: "cross talk" with other pathways in endocrine cells
    • Robinson-White A, Stratakis CA 2002 Protein kinase A signaling: "cross talk" with other pathways in endocrine cells. Ann NY Acad Sci 968:256-270
    • (2002) Ann NY Acad Sci , vol.968 , pp. 256-270
    • Robinson-White, A.1    Stratakis, C.A.2
  • 14
  • 15
    • 33751301602 scopus 로고    scopus 로고
    • PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes
    • DOI 10.1158/0008-5472.CAN-06-2200
    • Robinson-White AJ, Leitner WW, Aleem E, Kaldis P, Bossis I, Stratakis CA 2006 PRKAR1A inactivation leads to increased proliferation and decreased apoptosis in human B lymphocytes. Cancer Res 66:10603-10612 (Pubitemid 44799784)
    • (2006) Cancer Research , vol.66 , Issue.21 , pp. 10603-10612
    • Robinson-White, A.J.1    Leitner, W.W.2    Aleem, E.3    Kaldis, P.4    Bossis, I.5    Stratakis, C.A.6
  • 16
    • 0026764144 scopus 로고
    • Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′:5′-monophosphate
    • Langeveld CH, Jongenelen CA, Heimans JJ, Stoof JC 1992 Growth inhibition of human glioma cells induced by 8-chloroadenosine, an active metabolite of 8-chloro cyclic adenosine 3′:5′-monophosphate. Cancer Res 52:3994-3999
    • (1992) Cancer Res , vol.52 , pp. 3994-3999
    • Langeveld, C.H.1    Jongenelen, C.A.2    Heimans, J.J.3    Stoof, J.C.4
  • 17
    • 0035206293 scopus 로고    scopus 로고
    • 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs
    • DOI 10.1007/s00280-001-0379-1
    • Robbins SK, Houlbrook S, Priddle JD, Harris AL 2001 8-Cl-adenosine is an active metabolite of 8-Cl-cAMP responsible for its in vitro antiproliferative effects on CHO mutants hypersensitive to cytostatic drugs. Cancer Chemother Pharmacol 48:451-458 (Pubitemid 33139866)
    • (2001) Cancer Chemotherapy and Pharmacology , vol.48 , Issue.6 , pp. 451-458
    • Robbins, S.K.1    Houlbrook, S.2    Priddle, J.D.3    Harris, A.L.4
  • 18
    • 0024418926 scopus 로고
    • Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate
    • Ally S, Clair T, Katsaros D, Tortora G, Yokozaki H, Finch RA, Avery TL, Cho-Chung YS 1989 Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate. Cancer Res 49: 5650-5655 (Pubitemid 19256447)
    • (1989) Cancer Research , vol.49 , Issue.20 , pp. 5650-5655
    • Ally, S.1    Clair, T.2    Katsaros, D.3    Tortora, G.4    Yokozaki, H.5    Finch, R.A.6    Avery, T.L.7    Cho-chung, Y.S.8
  • 19
    • 0031021259 scopus 로고    scopus 로고
    • The antiproliferative effect of 8-chloroadenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate and disturbances in nucleic acid synthesis and cell cycle kinetics
    • Langeveld CH, Jongenelen CA, Theeuwes JWM, Baak JP, Heimans JJ, Stoof JC, Peters GJ 1997 The antiproliferative effect of 8-chloroadenosine, an active metabolite of 8-chloro-cyclic adenosine monophosphate and disturbances in nucleic acid synthesis and cell cycle kinetics. Biochem Pharm 53:141-148
    • (1997) Biochem Pharm , vol.53 , pp. 141-148
    • Langeveld, C.H.1    Jongenelen, C.A.2    Theeuwes, J.W.M.3    Baak, J.P.4    Heimans, J.J.5    Stoof, J.C.6    Peters, G.J.7
  • 20
    • 0345275863 scopus 로고    scopus 로고
    • RNA-Directed Actions of 8-Chloro-Adenosine in Multiple Myeloma Cells
    • Stellrecht CM, Rodriguez Jr CO, Ayres M, Gandhi V 2003 RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer Res 63:7968-7974 (Pubitemid 37466734)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7968-7974
    • Stellrecht, C.M.1    Rodriguez Jr., C.O.2    Ayres, M.3    Gandhi, V.4
  • 22
    • 0035878796 scopus 로고    scopus 로고
    • 8-Chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells
    • Gandhi V, Ayres M, Halgren RG, Krett NL, Newman RA, Rosen ST 2001 8-Chloro-cAMP and 8-chloro-adenosine act by the same mechanism in multiple myeloma cells. Cancer Res 61:5474-5479 (Pubitemid 32694929)
    • (2001) Cancer Research , vol.61 , Issue.14 , pp. 5474-5479
    • Gandhi, V.1    Ayres, M.2    Halgren, R.G.3    Krett, N.L.4    Newman, R.A.5    Rosen, S.T.6
  • 24
    • 0031960074 scopus 로고    scopus 로고
    • 8-Chloro-adenosine induced apoptosis in various human tumor cell lines
    • Zhang S, Zheng D, Liu S 1998 Chloro-adenosine induced apoptosis in various human tumor cell lines. Zhonghua Zhong Liu Za Zhi 20:88-89 (Pubitemid 28209179)
    • (1998) Chinese Journal of Oncology , vol.20 , Issue.2 , pp. 88-89
    • Siqing, Z.1    Dexian, Z.2    Shilian, L.3
  • 25
    • 0035069874 scopus 로고    scopus 로고
    • 8-Cl-adenosine mediated cytotoxicity and sensitization of T-lymphoblastic leukemia cells to TNFα-induced apoptosis is via inactivation of NF-κB
    • DOI 10.1016/S0145-2126(00)00147-8, PII S0145212600001478
    • Yin Y, Allen PD, Jia I, Kelsey SM, Newland AC 2001 8-Cl-adenosine mediated cytotoxicity and sensitization of T-l ymphoblast leukemia cells to TNFα-induced apoptosis is via inactivation of NF-κB. Leukemia Res 25:423-431 (Pubitemid 32294288)
    • (2001) Leukemia Research , vol.25 , Issue.5 , pp. 423-431
    • Yin, Y.1    Allen, P.D.2    Jia, L.3    Kelsey, S.M.4    Newland, A.C.5
  • 27
    • 0027456590 scopus 로고
    • 8-Cl-cAMP induces truncation and down-regulation of the RI(α) subunit and up-regulation of the RII(β) subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL- 60 leukemia cells
    • Rohlff C, Clair T, Cho-Chung YS 1993 8-Cl-cAMP induces truncation and down-regulation of the RIα subunit and up-regulation of the RIIβ subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells. J Biol Chem 268:5774-5782 (Pubitemid 23090906)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.8 , pp. 5774-5782
    • Rohlff, C.1    Clair, T.2    Cho-Chung, Y.S.3
  • 28
    • 48749085061 scopus 로고    scopus 로고
    • Human equilibrative nucleotide transporter (ENT) family of nucleoside and nucleobase transporter proteins
    • Young JD, Yao SY, Sun L, Cass CE, Baldwin SA 2008 Human equilibrative nucleotide transporter (ENT) family of nucleoside and nucleobase transporter proteins. Xenobiotica 38:995-1021
    • (2008) Xenobiotica , vol.38 , pp. 995-1021
    • Young, J.D.1    Yao, S.Y.2    Sun, L.3    Cass, C.E.4    Baldwin, S.A.5
  • 29
  • 30
    • 0033136943 scopus 로고    scopus 로고
    • Nucleoside transporters: Molecular biology and implications for therapeutic development
    • Baldwin SA, Mackey JR, Cass CE, Young JD 1999 Nucleoside transporters: molecular biology and implications for therapeutic development. Mol Med Today 5:216-224
    • (1999) Mol Med Today , vol.5 , pp. 216-224
    • Baldwin, S.A.1    Mackey, J.R.2    Cass, C.E.3    Young, J.D.4
  • 31
    • 35448998563 scopus 로고    scopus 로고
    • Molecular mechanisms of nucleoside and nucleobase transport
    • Barrett KE, DonowitzM,eds. San Diego: Academic Press
    • Young JD, Cheeseman CI, Mackey JR, Cass CE, Baldwin SA 2000 Molecular mechanisms of nucleoside and nucleobase transport. In: Barrett KE, DonowitzM,eds. Current topics in membranes. Vol.50. San Diego: Academic Press; 329-378
    • (2000) Current Topics in Membranes , vol.50 , pp. 329-378
    • Young, J.D.1    Cheeseman, C.I.2    Mackey, J.R.3    Cass, C.E.4    Baldwin, S.A.5
  • 32
  • 33
    • 33845996886 scopus 로고    scopus 로고
    • Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in Hep62 cells
    • Hermes M, Osswald H, Kloor D 2007 Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in Hep62 cells. Expt Cell Res 323:264-283
    • (2007) Expt Cell Res , vol.323 , pp. 264-283
    • Hermes, M.1    Osswald, H.2    Kloor, D.3
  • 34
    • 27644521069 scopus 로고    scopus 로고
    • Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death
    • DOI 10.1038/sj.onc.1208855, PII 1208855
    • Schwerk C, Schulze-Osthoff K 2005 Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death. Oncogene 24:7002-7011 (Pubitemid 41573629)
    • (2005) Oncogene , vol.24 , Issue.47 , pp. 7002-7011
    • Schwerk, C.1    Schulze-Osthoff, K.2
  • 35
    • 0034703084 scopus 로고    scopus 로고
    • Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
    • DOI 10.1074/jbc.M002725200
    • Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ 2000 Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275:29318-29323 (Pubitemid 32043802)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.38 , pp. 29318-29323
    • Yi, P.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Hine, R.J.5    James, S.J.6
  • 37
    • 0029671412 scopus 로고    scopus 로고
    • β
    • Nesterova M, Yokozaki H, McDuffie E, Cho-Chung YS 1996 Overexpression of RIIβ regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RIIβ. Eur J Biochem 235:486-494 (Pubitemid 126423616)
    • (1996) European Journal of Biochemistry , vol.235 , Issue.3 , pp. 486-494
    • Nesterova, M.1    Yokozaki, H.2    McDuffie, E.3    Cho-Chung, Y.S.4
  • 38
    • 4243810198 scopus 로고
    • A cyclic adenosine 3′,5′-monophosphate-dependent histone kinase from pig brain. Purification and some properties of the enzyme
    • Nesterova MV, Sashchemko LP, Vasiliev VY, Severen ES 1975 A cyclic adenosine 3′,5′-monophosphate-dependent histone kinase from pig brain. Purification and some properties of the enzyme. Biochim Biophys Acta 377:271-281
    • (1975) Biochim Biophys Acta , vol.377 , pp. 271-281
    • Nesterova, M.V.1    Sashchemko, L.P.2    Vasiliev, V.Y.3    Severen, E.S.4
  • 40
    • 0001984758 scopus 로고
    • Stability parameters for comparing varieties
    • Eberhart SA, Russell W 1966 Stability parameters for comparing varieties. Crop Sci 6:36-40
    • (1966) Crop Sci , vol.6 , pp. 36-40
    • Eberhart, S.A.1    Russell, W.2


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