Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in the kidney of streptozotocin-induced diabetic rats and its reversibity by interventive insulin treatment

Diabetologia

Volumn 46, Issue 10, 2003, Pages 1428-1437

  Etoh, T ^a   Inoguchi, T ^a   Kakimoto, M ^a   Sonoda, N ^a   Kobayashi, K ^a   Kuroda, J ^a   Sumimoto, H ^a   Nawata, H ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

8 hydroxy deoxyguanosine; NAD(P)H oxidase; Nephropathy; NOX4; Oxidative stress; p22phox

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; INSULIN; MESSENGER RNA; PROTEIN; PROTEIN NOX4; PROTEIN P22PHOX; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DNA DAMAGE; EVALUATION; GLOMERULUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY CELL; KIDNEY DISTAL TUBULE; MALE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; STREPTOZOCIN DIABETES;

ANIMALS; BIOLOGICAL MARKERS; CELLS, CULTURED; DEOXYGUANOSINE; DIABETES MELLITUS, EXPERIMENTAL; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLOMERULAR MESANGIUM; GLUCOSE; IMMUNOLOGIC TECHNIQUES; INSULIN; KIDNEY; MALE; MEMBRANE TRANSPORT PROTEINS; NADPH DEHYDROGENASE; NADPH OXIDASE; OSMOLAR CONCENTRATION; PHOSPHOPROTEINS; RATS; RATS, WISTAR; RNA, MESSENGER; STAINING AND LABELING; TISSUE DISTRIBUTION;

EID: 0042864155     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1205-6     Document Type: Article

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