메뉴 건너뛰기




Volumn 44, Issue 10, 2012, Pages 724-731

Different roles of GNAS and cAMP signaling during early and late stages of osteogenic differentiation

Author keywords

BMP; FD; fibrous dysplasia; POH; progressive osseous heteroplasia; SMAD

Indexed keywords

2',5' DIDEOXYADENOSINE; BONE MORPHOGENETIC PROTEIN; CYCLIC AMP; FORSKOLIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMAD PROTEIN;

EID: 84866083087     PISSN: 00185043     EISSN: 14394286     Source Type: Journal    
DOI: 10.1055/s-0032-1321845     Document Type: Article
Times cited : (53)

References (62)
  • 2
    • 77956275161 scopus 로고    scopus 로고
    • Inherited human diseases of heterotopic bone formation
    • Shore E M, Kaplan F S. Inherited human diseases of heterotopic bone formation. Nat Rev Rheumatol: 2010; 6 518 527
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 518-527
    • Shore, E.M.1    Kaplan, F.S.2
  • 3
    • 0034331685 scopus 로고    scopus 로고
    • Progressive osseous heteroplasia
    • Kaplan F S, Shore E M. Progressive osseous heteroplasia. J Bone Miner Res: 2000; 15 2084 2094
    • (2000) J Bone Miner Res , vol.15 , pp. 2084-2094
    • Kaplan, F.S.1    Shore, E.M.2
  • 5
    • 78650443572 scopus 로고    scopus 로고
    • Skeletal progenitors and the GNAS gene: Fibrous dysplasia of bone read through stem cells
    • Riminucci M, Robey P G, Saggio I, Bianco P. Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells. J Mol Endocrinol: 2010; 45 355 364
    • (2010) J Mol Endocrinol , vol.45 , pp. 355-364
    • Riminucci, M.1    Robey, P.G.2    Saggio, I.3    Bianco, P.4
  • 7
    • 33646252013 scopus 로고    scopus 로고
    • Genetic diseases associated with heterotrimeric G proteins
    • Weinstein L S, Chen M, Xie T, Liu J. Genetic diseases associated with heterotrimeric G proteins. Trends Pharmacol Sci: 2006; 27 260 266
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 260-266
    • Weinstein, L.S.1    Chen, M.2    Xie, T.3    Liu, J.4
  • 8
    • 67651163684 scopus 로고    scopus 로고
    • Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha)
    • Aydin C, Aytan N, Mahon M J, Tawfeek H A, Kowall N W, Dedeoglu A, Bastepe M. Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha). Endocrinology: 2009; 150 3567 3575
    • (2009) Endocrinology , vol.150 , pp. 3567-3575
    • Aydin, C.1    Aytan, N.2    Mahon, M.J.3    Tawfeek, H.A.4    Kowall, N.W.5    Dedeoglu, A.6    Bastepe, M.7
  • 9
    • 41549118947 scopus 로고    scopus 로고
    • The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts
    • Bastepe M. The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts. Curr Genomics: 2007; 8 398 414
    • (2007) Curr Genomics , vol.8 , pp. 398-414
    • Bastepe, M.1
  • 10
    • 0036020511 scopus 로고    scopus 로고
    • Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit
    • Bastepe M, Gunes Y, Perez-Villamil B, Hunzelman J, Weinstein L S, Juppner H. Receptor-mediated adenylyl cyclase activation through XLalpha(s), the extra-large variant of the stimulatory G protein alpha-subunit. Mol Endocrinol: 2002; 16 1912 1919
    • (2002) Mol Endocrinol , vol.16 , pp. 1912-1919
    • Bastepe, M.1    Gunes, Y.2    Perez-Villamil, B.3    Hunzelman, J.4    Weinstein, L.S.5    Juppner, H.6
  • 11
    • 3543036987 scopus 로고    scopus 로고
    • The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding
    • Plagge A, Gordon E, Dean W, Boiani R, Cinti S, Peters J, Kelsey G. The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding. Nat Genet: 2004; 36 818 826
    • (2004) Nat Genet , vol.36 , pp. 818-826
    • Plagge, A.1    Gordon, E.2    Dean, W.3    Boiani, R.4    Cinti, S.5    Peters, J.6    Kelsey, G.7
  • 12
    • 1542358991 scopus 로고    scopus 로고
    • Inherited diseases involving g proteins and g protein-coupled receptors
    • Spiegel A M, Weinstein L S. Inherited diseases involving g proteins and g protein-coupled receptors. Annu Rev Med: 2004; 55 27 39
    • (2004) Annu Rev Med , vol.55 , pp. 27-39
    • Spiegel, A.M.1    Weinstein, L.S.2
  • 13
    • 77950685384 scopus 로고    scopus 로고
    • Gs signaling in osteoblasts and hematopoietic stem cells
    • Kronenberg H M. Gs signaling in osteoblasts and hematopoietic stem cells. Ann NY Acad Sci 1192 327 329
    • Ann NY Acad Sci , vol.1192 , pp. 327-329
    • Kronenberg, H.M.1
  • 15
    • 69149101118 scopus 로고    scopus 로고
    • G protein signaling controls the differentiation of multiple cell lineages
    • Wang K, Wong Y H. G protein signaling controls the differentiation of multiple cell lineages. Biofactors: 2009; 35 232 238
    • (2009) Biofactors , vol.35 , pp. 232-238
    • Wang, K.1    Wong, Y.H.2
  • 16
    • 70449646962 scopus 로고    scopus 로고
    • Regulation of osterix (Osx, Sp7) and the Osx promoter by parathyroid hormone in osteoblasts
    • Hong S H, Lu X, Nanes M S, Mitchell J. Regulation of osterix (Osx, Sp7) and the Osx promoter by parathyroid hormone in osteoblasts. J Mol Endocrinol: 2009; 43 197 207
    • (2009) J Mol Endocrinol , vol.43 , pp. 197-207
    • Hong, S.H.1    Lu, X.2    Nanes, M.S.3    Mitchell, J.4
  • 17
    • 0030831889 scopus 로고    scopus 로고
    • Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (C3H10T1/2)
    • Hollnagel A, Ahrens M, Gross G. Parathyroid hormone enhances early and suppresses late stages of osteogenic and chondrogenic development in a BMP-dependent mesenchymal differentiation system (C3H10T1/2). J Bone Miner Res: 1997; 12 1993 2004
    • (1997) J Bone Miner Res , vol.12 , pp. 1993-2004
    • Hollnagel, A.1    Ahrens, M.2    Gross, G.3
  • 18
    • 0030962888 scopus 로고    scopus 로고
    • Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells
    • Ishizuya T, Yokose S, Hori M, Noda T, Suda T, Yoshiki S, Yamaguchi A. Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells. J Clin Invest: 1997; 99 2961 2970
    • (1997) J Clin Invest , vol.99 , pp. 2961-2970
    • Ishizuya, T.1    Yokose, S.2    Hori, M.3    Noda, T.4    Suda, T.5    Yoshiki, S.6    Yamaguchi, A.7
  • 19
    • 0029759907 scopus 로고    scopus 로고
    • Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages
    • Isogai Y, Akatsu T, Ishizuya T, Yamaguchi A, Hori M, Takahashi N, Suda T. Parathyroid hormone regulates osteoblast differentiation positively or negatively depending on the differentiation stages. J Bone Miner Res: 1996; 11 1384 1393
    • (1996) J Bone Miner Res , vol.11 , pp. 1384-1393
    • Isogai, Y.1    Akatsu, T.2    Ishizuya, T.3    Yamaguchi, A.4    Hori, M.5    Takahashi, N.6    Suda, T.7
  • 20
    • 0033304845 scopus 로고    scopus 로고
    • 3,5-Cyclic adenosine monophosphate activation in osteoblastic cells: Effects on parathyroid hormone-1 receptors and osteoblastic differentiation in vitro
    • Koh A J, Beecher C A, Rosol T J, McCauley L K. 3,5-Cyclic adenosine monophosphate activation in osteoblastic cells: effects on parathyroid hormone-1 receptors and osteoblastic differentiation in vitro. Endocrinology: 1999; 140 3154 3162
    • (1999) Endocrinology , vol.140 , pp. 3154-3162
    • Koh, A.J.1    Beecher, C.A.2    Rosol, T.J.3    McCauley, L.K.4
  • 21
    • 0032717355 scopus 로고    scopus 로고
    • Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development
    • Lanske B, Amling M, Neff L, Guiducci J, Baron R, Kronenberg H M. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J Clin Invest: 1999; 104 399 407
    • (1999) J Clin Invest , vol.104 , pp. 399-407
    • Lanske, B.1    Amling, M.2    Neff, L.3    Guiducci, J.4    Baron, R.5    Kronenberg, H.M.6
  • 22
    • 67349147522 scopus 로고    scopus 로고
    • PTH and PTHrP signaling in osteoblasts
    • Datta N S, Abou-Samra A B. PTH and PTHrP signaling in osteoblasts. Cell Signal: 2009; 21 1245 1254
    • (2009) Cell Signal , vol.21 , pp. 1245-1254
    • Datta, N.S.1    Abou-Samra, A.B.2
  • 27
    • 20444397369 scopus 로고    scopus 로고
    • Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone
    • Sakamoto A, Chen M, Nakamura T, Xie T, Karsenty G, Weinstein L S. Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical bone. J Biol Chem: 2005; 280 21369 21375
    • (2005) J Biol Chem , vol.280 , pp. 21369-21375
    • Sakamoto, A.1    Chen, M.2    Nakamura, T.3    Xie, T.4    Karsenty, G.5    Weinstein, L.S.6
  • 28
    • 0034455051 scopus 로고    scopus 로고
    • Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1
    • Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocr Rev: 2000; 21 393 411
    • (2000) Endocr Rev , vol.21 , pp. 393-411
    • Yamaguchi, A.1    Komori, T.2    Suda, T.3
  • 29
    • 77953365784 scopus 로고    scopus 로고
    • Extrinsic regulation of pluripotent stem cells
    • Pera M F, Tam P P. Extrinsic regulation of pluripotent stem cells. Nature 465 713 720
    • Nature , vol.465 , pp. 713-720
    • Pera, M.F.1    Tam, P.P.2
  • 30
    • 48749109823 scopus 로고    scopus 로고
    • Pluripotent stem cell lines
    • Yu J, Thomson J A. Pluripotent stem cell lines. Genes Dev: 2008; 22 1987 1997
    • (2008) Genes Dev , vol.22 , pp. 1987-1997
    • Yu, J.1    Thomson, J.A.2
  • 31
    • 34249283103 scopus 로고    scopus 로고
    • Embryonic stem-cell culture as a tool for developmental cell biology
    • Nishikawa S, Jakt L M, Era T. Embryonic stem-cell culture as a tool for developmental cell biology. Nat Rev Mol Cell Biol: 2007; 8 502 507
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 502-507
    • Nishikawa, S.1    Jakt, L.M.2    Era, T.3
  • 32
    • 33847653428 scopus 로고    scopus 로고
    • Concise review: Embryonic stem cells: A new tool to study osteoblast and osteoclast differentiation
    • Duplomb L, Dagouassat M, Jourdon P, Heymann D. Concise review: embryonic stem cells: a new tool to study osteoblast and osteoclast differentiation. Stem Cells: 2007; 25 544 552
    • (2007) Stem Cells , vol.25 , pp. 544-552
    • Duplomb, L.1    Dagouassat, M.2    Jourdon, P.3    Heymann, D.4
  • 33
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells
    • Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder J C. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci USA: 1993; 90 8424 8428
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 34
    • 34250860104 scopus 로고    scopus 로고
    • Methods for inducing embryoid body formation: In vitro differentiation system of embryonic stem cells
    • Kurosawa H. Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells. J Biosci Bioeng: 2007; 103 389 398
    • (2007) J Biosci Bioeng , vol.103 , pp. 389-398
    • Kurosawa, H.1
  • 36
    • 56049094776 scopus 로고    scopus 로고
    • Teasing out T-box targets in early mesoderm
    • Wardle F C, Papaioannou V E. Teasing out T-box targets in early mesoderm. Curr Opin Genet Dev: 2008; 18 418 425
    • (2008) Curr Opin Genet Dev , vol.18 , pp. 418-425
    • Wardle, F.C.1    Papaioannou, V.E.2
  • 37
    • 77955876027 scopus 로고    scopus 로고
    • Imprinting on chromosome 20: Tissue-specific imprinting and imprinting mutations in the GNAS locus
    • Kelsey G. Imprinting on chromosome 20: tissue-specific imprinting and imprinting mutations in the GNAS locus. Am J Med Genet C Semin Med Genet: 2010; 154C 377 386
    • (2010) Am J Med Genet C Semin Med Genet , vol.154 C , pp. 377-386
    • Kelsey, G.1
  • 38
    • 2342613539 scopus 로고    scopus 로고
    • Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications
    • Nuttall M E, Gimble J M. Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol: 2004; 4 290 294
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 290-294
    • Nuttall, M.E.1    Gimble, J.M.2
  • 39
    • 59149093623 scopus 로고    scopus 로고
    • Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program
    • Muruganandan S, Roman A A, Sinal C J. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci: 2009; 66 236 253
    • (2009) Cell Mol Life Sci , vol.66 , pp. 236-253
    • Muruganandan, S.1    Roman, A.A.2    Sinal, C.J.3
  • 41
    • 32044447008 scopus 로고    scopus 로고
    • Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells
    • Ryoo H M, Lee M H, Kim Y J. Critical molecular switches involved in BMP-2-induced osteogenic differentiation of mesenchymal cells. Gene: 2006; 366 51 57
    • (2006) Gene , vol.366 , pp. 51-57
    • Ryoo, H.M.1    Lee, M.H.2    Kim, Y.J.3
  • 42
    • 0242664267 scopus 로고    scopus 로고
    • MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors
    • Cheng S L, Shao J S, Charlton-Kachigian N, Loewy A P, Towler D A. MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors. J Biol Chem: 2003; 278 45969 45977
    • (2003) J Biol Chem , vol.278 , pp. 45969-45977
    • Cheng, S.L.1    Shao, J.S.2    Charlton-Kachigian, N.3    Loewy, A.P.4    Towler, D.A.5
  • 43
    • 77950238606 scopus 로고    scopus 로고
    • The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity
    • Madsen L, Kristiansen K. The importance of dietary modulation of cAMP and insulin signaling in adipose tissue and the development of obesity. Ann NY Acad Sci 1190 1 14
    • Ann NY Acad Sci , vol.1190 , pp. 1-14
    • Madsen, L.1    Kristiansen, K.2
  • 46
    • 84866141948 scopus 로고    scopus 로고
    • GNAS mRNAs from the Paternally-Inherited allele are Decreased in Progressive Osseous Heteroplasia (POH), a Human Disorder of Ectopic Ossification
    • Xu M, Kaplan F S, Shore E M. GNAS mRNAs from the Paternally-Inherited allele are Decreased in Progressive Osseous Heteroplasia (POH), a Human Disorder of Ectopic Ossification. J Bone Min Res: 2005; 20 S417
    • (2005) J Bone Min Res , vol.20
    • Xu, M.1    Kaplan, F.S.2    Shore, E.M.3
  • 48
    • 34547485288 scopus 로고    scopus 로고
    • A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells
    • Zhao Y, Ding S. A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells. Proc Natl Acad Sci USA: 2007; 104 9673 9678
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 9673-9678
    • Zhao, Y.1    Ding, S.2
  • 49
    • 33745839778 scopus 로고    scopus 로고
    • Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage
    • Yamashita A, Takada T, Nemoto K, Yamamoto G, Torii R. Transient suppression of PPARgamma directed ES cells into an osteoblastic lineage. FEBS Lett: 2006; 580 4121 4125
    • (2006) FEBS Lett , vol.580 , pp. 4121-4125
    • Yamashita, A.1    Takada, T.2    Nemoto, K.3    Yamamoto, G.4    Torii, R.5
  • 51
    • 61449123058 scopus 로고    scopus 로고
    • PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells
    • Shockley K R, Lazarenko O P, Czernik P J, Rosen C J, Churchill G A, Lecka-Czernik B. PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cells. J Cell Biochem: 2009; 106 232 246
    • (2009) J Cell Biochem , vol.106 , pp. 232-246
    • Shockley, K.R.1    Lazarenko, O.P.2    Czernik, P.J.3    Rosen, C.J.4    Churchill, G.A.5    Lecka-Czernik, B.6
  • 52
    • 74249123592 scopus 로고    scopus 로고
    • The role of GNAS and other imprinted genes in the development of obesity
    • Weinstein L S, Xie T, Qasem A, Wang J, Chen M. The role of GNAS and other imprinted genes in the development of obesity. Int J Obes (Lond): 2010; 34 6 17
    • (2010) Int J Obes (Lond) , vol.34 , pp. 6-17
    • Weinstein, L.S.1    Xie, T.2    Qasem, A.3    Wang, J.4    Chen, M.5
  • 53
    • 39749100503 scopus 로고    scopus 로고
    • Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse
    • Plagge A, Kelsey G, Germain-Lee E L. Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse. J Endocrinol: 2008; 196 193 214
    • (2008) J Endocrinol , vol.196 , pp. 193-214
    • Plagge, A.1    Kelsey, G.2    Germain-Lee, E.L.3
  • 54
    • 77951024744 scopus 로고    scopus 로고
    • Beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling
    • Li H, Fong C, Chen Y, Cai G, Yang M. beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling. Arch Biochem Biophys: 2010; 496 77 83
    • (2010) Arch Biochem Biophys , vol.496 , pp. 77-83
    • Li, H.1    Fong, C.2    Chen, Y.3    Cai, G.4    Yang, M.5
  • 55
    • 0032571363 scopus 로고    scopus 로고
    • CAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification
    • Tintut Y, Parhami F, Bostrom K, Jackson S M, Demer L L. cAMP stimulates osteoblast-like differentiation of calcifying vascular cells. Potential signaling pathway for vascular calcification. J Biol Chem: 1998; 273 7547 7553
    • (1998) J Biol Chem , vol.273 , pp. 7547-7553
    • Tintut, Y.1    Parhami, F.2    Bostrom, K.3    Jackson, S.M.4    Demer, L.L.5
  • 56
    • 84857862385 scopus 로고    scopus 로고
    • Forskolin enhances in vivo bone formation by human mesenchymal stromal cells
    • Doorn J, Siddappa R, van Blitterswijk C A, de Boer J. Forskolin enhances in vivo bone formation by human mesenchymal stromal cells. Tissue Eng Part A: 2012; 18 558 567
    • (2012) Tissue Eng Part A , vol.18 , pp. 558-567
    • Doorn, J.1    Siddappa, R.2    Van Blitterswijk, C.A.3    De Boer, J.4
  • 58
    • 80052708936 scopus 로고    scopus 로고
    • The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization
    • Lo K W, Kan H M, Ashe K M, Laurencin C T. The small molecule PKA-specific cyclic AMP analogue as an inducer of osteoblast-like cells differentiation and mineralization. J Tissue Eng Regen Med: 2012; 6 40 48
    • (2012) J Tissue Eng Regen Med , vol.6 , pp. 40-48
    • Lo, K.W.1    Kan, H.M.2    Ashe, K.M.3    Laurencin, C.T.4
  • 59
    • 0021999781 scopus 로고
    • Induction of osteoblastic cell differentiation by forskolin. Stimulation of cyclic AMP production and alkaline phosphatase activity
    • Hakeda Y, Ikeda E, Kurihara N, Nakatani Y, Maeda N, Kumegawa M. Induction of osteoblastic cell differentiation by forskolin. Stimulation of cyclic AMP production and alkaline phosphatase activity. Biochim Biophys Acta: 1985; 838 49 53
    • (1985) Biochim Biophys Acta , vol.838 , pp. 49-53
    • Hakeda, Y.1    Ikeda, E.2    Kurihara, N.3    Nakatani, Y.4    Maeda, N.5    Kumegawa, M.6
  • 60
    • 63449107147 scopus 로고    scopus 로고
    • Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3,5-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells
    • Nakao Y, Koike T, Ohta Y, Manaka T, Imai Y, Takaoka K. Parathyroid hormone enhances bone morphogenetic protein activity by increasing intracellular 3,5-cyclic adenosine monophosphate accumulation in osteoblastic MC3T3-E1 cells. Bone: 2009; 44 872 877
    • (2009) Bone , vol.44 , pp. 872-877
    • Nakao, Y.1    Koike, T.2    Ohta, Y.3    Manaka, T.4    Imai, Y.5    Takaoka, K.6
  • 61
    • 45249122818 scopus 로고    scopus 로고
    • CAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin
    • Yang D C, Tsay H J, Lin S Y, Chiou S H, Li M J, Chang T J, Hung S C. cAMP/PKA regulates osteogenesis, adipogenesis and ratio of RANKL/OPG mRNA expression in mesenchymal stem cells by suppressing leptin. PLoS One: 2008; 3 e1540
    • (2008) PLoS One , vol.3
    • Yang, D.C.1    Tsay, H.J.2    Lin, S.Y.3    Chiou, S.H.4    Li, M.J.5    Chang, T.J.6    Hung, S.C.7
  • 62
    • 69149091047 scopus 로고    scopus 로고
    • BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage
    • Huang H, Song T J, Li X, Hu L, He Q, Liu M, Lane M D, Tang Q Q. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A: 2009; 106 12670 12675
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12670-12675
    • Huang, H.1    Song, T.J.2    Li, X.3    Hu, L.4    He, Q.5    Liu, M.6    Lane, M.D.7    Tang, Q.Q.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.